INT14736

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Context Info
Confidence 0.47
First Reported 1991
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.65
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL6A2) extracellular region (COL6A2) proteinaceous extracellular matrix (COL6A2)
protein binding, bridging (COL6A2) extracellular matrix organization (COL6A2) protein complex (COL6A2)
Anatomy Link Frequency
cartilage 1
skin 1
COL6A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 4 99.82 Very High Very High Very High
cytokine 10 58.20 Quite High
Osteoarthritis 16 5.00 Very Low Very Low Very Low
Inflammation 15 5.00 Very Low Very Low Very Low
rheumatoid arthritis 11 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 8 99.52 Very High Very High Very High
Fasciitis 6 99.52 Very High Very High Very High
Myalgia 4 99.24 Very High Very High Very High
Eosinophilia 4 99.08 Very High Very High Very High
Apoptosis 30 5.00 Very Low Very Low Very Low
Osteoarthritis 23 5.00 Very Low Very Low Very Low
INFLAMMATION 17 5.00 Very Low Very Low Very Low
Aging 15 5.00 Very Low Very Low Very Low
Injury 15 5.00 Very Low Very Low Very Low
Necrosis 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Full-thickness skin biopsies obtained from four patients with rapidly progressive diffuse fasciitis associated with the Eosinophilia-Myalgia syndrome (EMS) were examined for the expression of transforming growth factor-beta 1 (TGF-beta 1), type VI collagen, and fibronectin genes employing immunohistochemistry and in situ hybridizations.
Spec (examined) Gene_expression (expression) of type VI collagen in skin associated with syndrome, fasciitis, myalgia and eosinophilia
1) Confidence 0.47 Published 1991 Journal J. Invest. Dermatol. Section Abstract Doc Link 1702819 Disease Relevance 0.80 Pain Relevance 0
Elevated expression of the genes for transforming growth factor-beta 1 and type VI collagen in diffuse fasciitis associated with the eosinophilia-myalgia syndrome.
Gene_expression (expression) of type VI collagen associated with pain, syndrome, fasciitis, myalgia and eosinophilia
2) Confidence 0.47 Published 1991 Journal J. Invest. Dermatol. Section Title Doc Link 1702819 Disease Relevance 0.85 Pain Relevance 0.13
Collagen type VI is found pericellularly around chondrocytes [4], and collagen type X is found in calcifying cartilage [5].
Gene_expression (found) of Collagen type VI in cartilage
3) Confidence 0.08 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206353 Disease Relevance 0 Pain Relevance 0

General Comments

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