INT147366

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 17
Disease Relevance 9.84
Pain Relevance 6.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hist1h1t) chromosome (Hist1h1t) nucleus (Hist1h1t)
intracellular (Hist1h1t) DNA binding (Hist1h1t)
Anatomy Link Frequency
neurons 2
visceral 1
neuronal 1
colon 1
paw 1
Hist1h1t (Rattus norvegicus)
Pain Link Frequency Relevance Heat
potassium channel 34 99.96 Very High Very High Very High
Hippocampus 13 99.60 Very High Very High Very High
dorsal root ganglion 403 99.16 Very High Very High Very High
nud 286 98.96 Very High Very High Very High
Calcium channel 54 98.48 Very High Very High Very High
nMDA receptor 13 98.48 Very High Very High Very High
Raphe 13 98.48 Very High Very High Very High
Visceral pain 52 98.44 Very High Very High Very High
Inflammation 132 97.92 Very High Very High Very High
Hyperalgesia 39 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 403 99.16 Very High Very High Very High
Nociception 84 99.04 Very High Very High Very High
Dyspepsia 286 98.96 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

52 98.44 Very High Very High Very High
INFLAMMATION 130 97.92 Very High Very High Very High
Syndrome 26 97.88 Very High Very High Very High
Hyperalgesia 39 97.84 Very High Very High Very High
Pressure And Volume Under Development 3 97.10 Very High Very High Very High
Inflammatory Pain 16 96.80 Very High Very High Very High
Pain 104 95.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hydrogen sulfide (H2S), which is well known traditionally as a toxic gas, has been proven to be produced endogenously by 3 enzymes in mammalian tissues and plays important roles in physiological and pathophysiological conditions.
Gene_expression (produced) of H2S
1) Confidence 0.44 Published 2007 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 17959020 Disease Relevance 0.08 Pain Relevance 0.04
Most of these studies showed that H2S exerts its function through acting on different ion channels.89

Effects of H2S on ATP dependent potassium channel (KATP)

Gene_expression (exerts) of H2S associated with potassium channel
2) Confidence 0.35 Published 2010 Journal Journal of Cardiovascular Disease Research Section Body Doc Link PMC3004170 Disease Relevance 0.44 Pain Relevance 0.31
Therefore, they concluded that H2S opened KATP channels and further closed the calcium channels.
Gene_expression (opened) of H2S associated with calcium channel and potassium channel
3) Confidence 0.31 Published 2010 Journal Journal of Cardiovascular Disease Research Section Body Doc Link PMC3004170 Disease Relevance 0 Pain Relevance 0.60
Both nociceptive flinching and hind paw edema induced by injection of 5% formalin were attenuated by pretreatment with DL-propargylglycine (PPG; 50 mg/kg, i.p.) which is an inhibitor of the H2S synthesizing enzyme cystathionine-gamma-lyase (CSE).
Gene_expression (synthesizing) of H2S in paw associated with nociception and pressure and volume under development
4) Confidence 0.31 Published 2008 Journal Neuroscience Section Abstract Doc Link 18248901 Disease Relevance 0.83 Pain Relevance 0.18
The expression of the other H2S producing enzyme CSE was also determined.
Spec (determined) Gene_expression (expression) of H2S
5) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.48 Pain Relevance 0.24
The expression of the other H2S producing enzyme CSE was also determined.
Gene_expression (producing) of H2S
6) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.48 Pain Relevance 0.24
Theoretically, enhanced H2S production from either a colonic or a neuronal source can affect the function of sensory neurons in our model and contribute to both enhanced pain as well as the secretomotor response that has previously been shown in guinea pigs [10].
Gene_expression (production) of H2S in neuronal associated with pain
7) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.50 Pain Relevance 0.25
The H2S-producing enzyme CBS is expressed by colonic specific DRG neurons
Gene_expression (producing) of H2S in neurons associated with dorsal root ganglion
8) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.29 Pain Relevance 0.11
We have confirmed previous studies on the expression of CBS and CSE in the colon and further have shown that CBS, but not CSE, is expressed by colon-specific sensory neurons (Fig. 1), where it is localized to nociceptive neurons, indicating that CBS is a major enzyme responsible for the endogenous production of H2S in these cells.
Gene_expression (production) of H2S in colon associated with nociception
9) Confidence 0.07 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.57 Pain Relevance 0.31
The concentration of H2S may not be an explanation for the different results since the same dose of H2S used by two different groups produced the different effects [11,14,15].
Gene_expression (produced) of H2S
10) Confidence 0.06 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.85 Pain Relevance 0.49
H2S has been reported to produce inward or outward currents on dorsal raphe serotonergic neurons in vitro [29].
Gene_expression (produce) of H2S in serotonergic neurons associated with raphe
11) Confidence 0.06 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.63 Pain Relevance 0.71
The H2S-producing enzyme CBS is expressed by colonic specific DRG neurons
Gene_expression (expressed) of H2S in neurons associated with dorsal root ganglion
12) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.29 Pain Relevance 0.12
We therefore determined the role for the endogenous H2S producing enzyme cystathionine-?
Gene_expression (producing) of H2S
13) Confidence 0.05 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2731739 Disease Relevance 1.08 Pain Relevance 0.91
Taken together, our results suggest but do not prove that CBS may be an important source of endogenous H2S and a credible therapeutic target for visceral pain syndromes.
Gene_expression (source) of H2S in visceral associated with visceral pain and syndrome
14) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.52 Pain Relevance 0.45
An additional source of H2S comes from sulfate-reducing bacteria in the GI tract [36-38].
Gene_expression (source) of H2S
15) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.44 Pain Relevance 0.28
Our study shows that the H2S producing enzyme cystathionine ?
Gene_expression (producing) of H2S
16) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.60 Pain Relevance 0.65
Further, H2S generation is also enhanced in the formalin [12] and carrageenan [13] model of persistent inflammatory pain.
Gene_expression (generation) of H2S associated with ipn
17) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 1.10 Pain Relevance 0.76

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