INT14737

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Context Info
Confidence 0.78
First Reported 1981
Last Reported 2010
Negated 3
Speculated 8
Reported most in Body
Documents 117
Total Number 126
Disease Relevance 78.74
Pain Relevance 18.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (FN1) extracellular region (FN1) cell adhesion (FN1)
proteinaceous extracellular matrix (FN1)
Anatomy Link Frequency
endothelial cell 7
TMJ 6
fibroblasts 4
skin 4
extracellular matrix 3
FN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 463 100.00 Very High Very High Very High
chemokine 247 100.00 Very High Very High Very High
metalloproteinase 196 100.00 Very High Very High Very High
Nerve growth factor 57 100.00 Very High Very High Very High
Snapping jaw 78 99.96 Very High Very High Very High
Spinal cord 185 99.90 Very High Very High Very High
dexamethasone 53 99.80 Very High Very High Very High
Endocannabinoid 120 99.64 Very High Very High Very High
antagonist 224 99.52 Very High Very High Very High
fibrosis 158 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neutropenia 649 100.00 Very High Very High Very High
Fever 90 100.00 Very High Very High Very High
Boutonneuse Fever 82 100.00 Very High Very High Very High
Premature Birth 66 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 465 99.98 Very High Very High Very High
Temporomandibular Joint Syndrome 78 99.96 Very High Very High Very High
Chronic Lymphoid Leukemia 228 99.92 Very High Very High Very High
Uterine Fibroids 611 99.84 Very High Very High Very High
Myocardial Infarction 575 99.84 Very High Very High Very High
Recurrence 16 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Normal disk tissues revealed weak fibronectin expression, which was mainly located along the collagen bundles.
Gene_expression (expression) of fibronectin
1) Confidence 0.78 Published 2004 Journal J Craniofac Surg Section Abstract Doc Link 15213552 Disease Relevance 0.67 Pain Relevance 0.60
The objective of this study was to investigate the expression of fibronectin in human temporomandibular joint disks obtained from patients with internal derangement and varying extents of disk tissue degeneration/regeneration with that of temporomandibular joint disks free of significant morphological alterations by means of immunohistochemical methods.
Spec (investigate) Gene_expression (expression) of fibronectin in temporomandibular joint associated with snapping jaw
2) Confidence 0.78 Published 2004 Journal J Craniofac Surg Section Abstract Doc Link 15213552 Disease Relevance 0.51 Pain Relevance 0.41
The findings suggest that temporomandibular joint disk tissue can express fibronectin and that the expression is more pronounced in disk specimens of patients with internal derangement of the temporomandibular joint, supporting a role of this glycoprotein in the degeneration/regeneration processes of human temporomandibular joint disk tissue.
Gene_expression (express) of fibronectin in temporomandibular joint associated with snapping jaw
3) Confidence 0.78 Published 2004 Journal J Craniofac Surg Section Abstract Doc Link 15213552 Disease Relevance 0.68 Pain Relevance 0.68
In the covering layer of the disk surface, fibronectin was expressed in a fascicular pattern running parallel to the disk surface.
Gene_expression (expressed) of fibronectin in covering
4) Confidence 0.78 Published 2004 Journal J Craniofac Surg Section Abstract Doc Link 15213552 Disease Relevance 0.65 Pain Relevance 0.67
Fibronectin, a human fibroblast surface and plasma protein, is present in cryoprecipitates of synovial fluids and/or sera from patients with rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, and mixed essential cryoglobulinemia.
Gene_expression (present) of Fibronectin in synovial fluids associated with cryoglobulinemia, spinal inflammation, rheumatoid arthritis and systemic lupus erythematosus
5) Confidence 0.77 Published 1981 Journal Arthritis Rheum. Section Abstract Doc Link 7317115 Disease Relevance 0.53 Pain Relevance 0.18
Lastly, using fluorescent staining, we examined fibronectin and collagen I expression in TMJ discs.
Spec (examined) Gene_expression (expression) of fibronectin in TMJ
6) Confidence 0.74 Published 2009 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 19070755 Disease Relevance 0 Pain Relevance 0
Fibronectin or collagen I expression in human TMJ synovial aspirates and disc tissue may indicate the proteins' involvement in closed lock.
Gene_expression (expression) of Fibronectin in TMJ associated with snapping jaw
7) Confidence 0.74 Published 2009 Journal J. Oral Maxillofac. Surg. Section Abstract Doc Link 19070755 Disease Relevance 0.81 Pain Relevance 0.58
CONCLUSIONS: The levels of fibronectin and collagen I in the TMJ disc and synovial fluid may be influenced by the stage of disease.
Gene_expression (levels) of fibronectin in TMJ
8) Confidence 0.74 Published 2009 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 19070755 Disease Relevance 0 Pain Relevance 0
We compared the fluorescent staining and light microscopy results of both proteins within each disc to confirm fibronectin and collagen I expression.
Gene_expression (expression) of fibronectin
9) Confidence 0.74 Published 2009 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 19070755 Disease Relevance 0 Pain Relevance 0
This may explain why transcriptomic analysis of blood cells performed in the present study failed to readily detect FN1 expression and a potential association with clinical outcome of MI patients (i.e., FN1 is not differentially expressed by HF and non-HF patients).
Neg (not) Gene_expression (expressed) of FN1 in blood cells associated with myocardial infarction
10) Confidence 0.71 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2890499 Disease Relevance 1.57 Pain Relevance 0.07
This may explain why transcriptomic analysis of blood cells performed in the present study failed to readily detect FN1 expression and a potential association with clinical outcome of MI patients (i.e., FN1 is not differentially expressed by HF and non-HF patients).
Gene_expression (expression) of FN1 in blood cells associated with myocardial infarction
11) Confidence 0.71 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2890499 Disease Relevance 1.56 Pain Relevance 0.06
Analysis of the collagen I and fibronectin of temporomandibular joint synovial fluid and discs.
Gene_expression (Analysis) of fibronectin in synovial fluid associated with snapping jaw
12) Confidence 0.64 Published 2009 Journal J. Oral Maxillofac. Surg. Section Title Doc Link 19070755 Disease Relevance 0.76 Pain Relevance 0.55
There was no considerable difference in detection of either fibronectin or collagen I in TMJ synovial aspirates from patients with advanced disc pathology compared with controls.
Gene_expression (detection) of fibronectin in TMJ
13) Confidence 0.64 Published 2009 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 19070755 Disease Relevance 0 Pain Relevance 0
RESULTS: Disc specimens with advanced morphologic pathology showed significant labeling for fibronectin in 3 of 3 cases and for collagen I in 4 of 4 cases.
Gene_expression (significant) of fibronectin
14) Confidence 0.64 Published 2009 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 19070755 Disease Relevance 0 Pain Relevance 0
The list of correspondingly important up-regulated genes in NHEK was extensive and included activin A, transglutaminase 2 (TGM2), ErbB3 (HER3), matrix metalloproteinase 9 (MMP-9), fibronectin (FN!)
Gene_expression (included) of fibronectin associated with metalloproteinase
15) Confidence 0.64 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.13 Pain Relevance 0.12
The list of correspondingly important up-regulated genes in NHEK was extensive and included activin A, transglutaminase 2 (TGM2), ErbB3 (HER3), matrix metalloproteinase 9 (MMP-9), fibronectin (FN!)
Gene_expression (included) of FN associated with metalloproteinase
16) Confidence 0.64 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.13 Pain Relevance 0.12
Proteins fibronectin 1 (FN1), integrin beta 1 (ITGB1) and platelet-derived growth factor receptor beta (PDGFRB) represent the top three 3 communication "hotpots" with the highest degree and traffic values in this network.
Gene_expression (represent) of fibronectin in platelet
17) Confidence 0.62 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2890499 Disease Relevance 0.20 Pain Relevance 0
ITGB1 and FN1 were identified among the top-3 high-traffic proteins.
Gene_expression (identified) of FN1
18) Confidence 0.62 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2890499 Disease Relevance 0.56 Pain Relevance 0.04
Proteins fibronectin 1 (FN1), integrin beta 1 (ITGB1) and platelet-derived growth factor receptor beta (PDGFRB) represent the top three 3 communication "hotpots" with the highest degree and traffic values in this network.
Gene_expression (represent) of FN1 in platelet
19) Confidence 0.62 Published 2010 Journal BMC Syst Biol Section Body Doc Link PMC2890499 Disease Relevance 0.20 Pain Relevance 0
Causes of FP and FN ratings were massive calcifications in nine segments (eight FP, one FN) and motion artifacts in two segments (one FP, one FN).
Gene_expression (ratings) of FN
20) Confidence 0.56 Published 2006 Journal Eur Radiol Section Body Doc Link PMC1705545 Disease Relevance 0.33 Pain Relevance 0

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