INT147384

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 0.41
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm5) plasma membrane (Grm5) cytoplasm (Grm5)
signal transducer activity (Grm5)
Anatomy Link Frequency
pyramidal neurons 2
neurons 2
neural 2
Grm5 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 32 100.00 Very High Very High Very High
Calcium channel 70 99.84 Very High Very High Very High
Hippocampus 20 99.00 Very High Very High Very High
Pyramidal cell 75 98.40 Very High Very High Very High
Action potential 110 96.68 Very High Very High Very High
Glutamate 36 94.44 High High
GABA receptor 10 91.96 High High
addiction 40 86.80 High High
agonist 11 80.48 Quite High
tetrodotoxin 11 71.12 Quite High
Disease Link Frequency Relevance Heat
Disease 10 99.66 Very High Very High Very High
Targeted Disruption 36 93.44 High High
Epilepsy 5 54.88 Quite High
Intellectual Impairment 5 54.48 Quite High
Neurological Disease 5 53.12 Quite High
Sprains And Strains 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of group I metabotropic glutamate receptor (mGluR1 and mGluR5) activation on identified melanin-concentrating hormone (MCH) neurons was studied using patch-clamp recording in hypothalamic slices from green fluorescent protein-expressing transgenic mice.
Regulation (effect) of Positive_regulation (activation) of mGluR5 in neurons associated with targeted disruption and glutamate receptor
1) Confidence 0.11 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17959799 Disease Relevance 0.09 Pain Relevance 0.20
Effects of mGluR activation on subthreshold membrane potential changes are negligible but are large following action potential firing.
Regulation (Effects) of Positive_regulation (activation) of mGluR associated with action potential
2) Confidence 0.06 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.43
Activation of group I metabotropic glutamate receptors (subtypes mGluR1 and mGluR5) regulates neural activity in a variety of ways.
Regulation (regulates) of Positive_regulation (Activation) of mGluR5 in neural associated with glutamate receptor
3) Confidence 0.06 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.32
Because of the importance of these modulatory effects for hippocampus-dependent functions and diseases, we studied the effects of activating group I mGluRs on the excitability of hippocampal CA1 pyramidal neurons.
Regulation (effects) of Positive_regulation (activating) of mGluRs in pyramidal neurons associated with pyramidal cell, hippocampus and disease
4) Confidence 0.03 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0.32 Pain Relevance 0.32
To determine the role of group I mGluR activation in the induction of the post-burst ADP, we applied blockers of mGluR1 and mGluR5 (Figure 3B and 3C).
Spec (determine) Regulation (role) of Positive_regulation (activation) of mGluR
5) Confidence 0.03 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.24
Instead, our focus is on the acute modulation of the AHP/ADP during activation of group I mGluRs.
Regulation (modulation) of Positive_regulation (activation) of mGluRs
6) Confidence 0.03 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.14

General Comments

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