INT1474

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Context Info
Confidence 0.61
First Reported 1977
Last Reported 2010
Negated 20
Speculated 22
Reported most in Abstract
Documents 132
Total Number 154
Disease Relevance 25.96
Pain Relevance 43.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
pancreas 40
pancreatic islets 12
plasma 10
islets of Langerhans 10
vagus nerve 6
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 138 100.00 Very High Very High Very High
agonist 87 100.00 Very High Very High Very High
tolerance 82 100.00 Very High Very High Very High
Enkephalin 81 100.00 Very High Very High Very High
antagonist 71 100.00 Very High Very High Very High
anesthesia 59 100.00 Very High Very High Very High
Somatostatin 51 100.00 Very High Very High Very High
Morphine 47 100.00 Very High Very High Very High
narcan 39 100.00 Very High Very High Very High
Dynorphin 21 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Impaired Glucose Tolerance 89 100.00 Very High Very High Very High
Insulin Resistance 42 100.00 Very High Very High Very High
Stress 34 100.00 Very High Very High Very High
Urological Neuroanatomy 24 100.00 Very High Very High Very High
Renal Failure 14 100.00 Very High Very High Very High
Congenital Anomalies 5 100.00 Very High Very High Very High
Diabetes Mellitus 812 99.84 Very High Very High Very High
Hypokinesia 1 99.82 Very High Very High Very High
Disease 32 99.80 Very High Very High Very High
Hypoglycemia 42 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to investigate the role of medial preoptic area (MPOA) adrenoceptors in regulation of plasma glucose and insulin secretion, we injected 40 nmol of noradrenaline, clonidine or isoproterenol into the MPOA of freely moving Wistar rats.
Spec (investigate) Regulation (role) of Localization (secretion) of insulin in preoptic area associated with noradrenaline, urological neuroanatomy and clonidine
1) Confidence 0.61 Published 2003 Journal Brain Res. Section Abstract Doc Link 12957368 Disease Relevance 0.58 Pain Relevance 0.27
In capsaicin treated animals, oral glucose tolerance was markedly improved both in NC and DC whereas insulin secretion was not affected.
Neg (not) Regulation (affected) of Localization (secretion) of insulin associated with qutenza, tolerance and impaired glucose tolerance
2) Confidence 0.61 Published 1996 Journal Life Sci. Section Abstract Doc Link 8809210 Disease Relevance 0.77 Pain Relevance 0.59
To elucidate the direct effect of an intestinal osmolality on insulin release, we investigated the insulin response to intra-duodenal infusion of mannitol in rats.
Regulation (effect) of Localization (release) of insulin
3) Confidence 0.61 Published 1992 Journal Life Sci. Section Abstract Doc Link 1357519 Disease Relevance 0 Pain Relevance 0.09
The effect of glucose on the release of insulin from the pancreas of 19.5- to 21.5-day-old rat fetuses has been studied in utero.
Regulation (effect) of Localization (release) of insulin in pancreas
4) Confidence 0.61 Published 1979 Journal Biol. Neonate Section Abstract Doc Link 383163 Disease Relevance 0.35 Pain Relevance 0.06
Anesthesia and its possible secondary inhibitory effects on insulin secretion were avoided by a spinal sectioning of the rats in the cervical region, before experimentation.
Spec (possible) Regulation (effects) of Localization (secretion) of insulin in cervical region associated with anesthesia
5) Confidence 0.61 Published 1985 Journal Endocrinology Section Abstract Doc Link 3891316 Disease Relevance 0 Pain Relevance 0.34
This study suggests that these two sulfonylurea hypoglycemic agents may affect insulin secretion by different mechanisms.
Spec (may) Regulation (affect) of Localization (secretion) of insulin
6) Confidence 0.61 Published 1984 Journal Diabetes Section Abstract Doc Link 6327436 Disease Relevance 0 Pain Relevance 0.12
These results suggest that the hepatic vagus nerve plays a role in the regulation of insulin secretion.
Regulation (plays) of Localization (secretion) of insulin in vagus nerve associated with vagus nerve
7) Confidence 0.61 Published 1985 Journal Endocrinology Section Abstract Doc Link 3891316 Disease Relevance 0 Pain Relevance 0.23
Effects of alpha-adrenoceptor agonists and antagonists on insulin secreting cells and pancreatic blood vessels: comparative study.
Regulation (Effects) of in blood vessels Localization (secreting) of insulin in insulin secreting cells associated with antagonist and agonist
8) Confidence 0.61 Published 1985 Journal Eur. J. Pharmacol. Section Title Doc Link 2866972 Disease Relevance 0 Pain Relevance 0.44
The hepatic vagus nerve and the neural regulation of insulin secretion.
Regulation (regulation) of Localization (secretion) of insulin in neural associated with vagus nerve
9) Confidence 0.61 Published 1985 Journal Endocrinology Section Title Doc Link 3891316 Disease Relevance 0 Pain Relevance 0.32
Hyperinsulinemia, a main feature of both human and animal obesity, has been demonstrated to be due to both an increased sensitivity to nutrient secretagogues and an impairment of the nervous regulation of insulin secretion.
Regulation (regulation) of Localization (secretion) of insulin associated with obesity and hyperinsulinism
10) Confidence 0.61 Published 1992 Journal Am. J. Physiol. Section Abstract Doc Link 1590384 Disease Relevance 0.49 Pain Relevance 0
Effect of diltiazem on insulin secretion was investigated in the perfused rat pancreas.
Regulation (Effect) of Localization (secretion) of insulin in pancreas
11) Confidence 0.61 Published 1979 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 395348 Disease Relevance 0 Pain Relevance 0
Insulin release in the presence of glucose at 2 or 12 mmol/l was not affected by DAMME (8.3 X 10(-8) mol/l).
Neg (not) Regulation (affected) of Localization (release) of Insulin
12) Confidence 0.61 Published 1981 Journal Diabetologia Section Abstract Doc Link 6790327 Disease Relevance 0.09 Pain Relevance 0.25
The potentiatory effect of DAMME on insulin release in the presence of glucose (5 mmol/l) was blocked by naloxone (11 mumol/l): naloxone alone did not affect glucose-stimulated insulin release.
Neg (not) Regulation (affect) of Localization (release) of insulin associated with narcan
13) Confidence 0.61 Published 1981 Journal Diabetologia Section Abstract Doc Link 6790327 Disease Relevance 0.08 Pain Relevance 0.31
[Effects of clonidine on the insulin secretion from the isolated, perfused pancreas of rats and newborn dogs].
Regulation (Effects) of Localization (secretion) of insulin in pancreas associated with clonidine
14) Confidence 0.60 Published 1983 Journal C. R. Seances Soc. Biol. Fil. Section Title Doc Link 6225489 Disease Relevance 0 Pain Relevance 0.51
In addition, racecadotril showed no direct effect on insulin secretion in isolated islets or cultured HIT-T15 beta cells.
Neg (no) Regulation (effect) of Localization (secretion) of insulin in beta cells
15) Confidence 0.60 Published 2010 Journal Horm. Metab. Res. Section Abstract Doc Link 20143290 Disease Relevance 0.05 Pain Relevance 0.17
Phentolamine, a deceptive tool to investigate sympathetic nervous control of insulin release.
Spec (investigate) Regulation (control) of Spec (investigate) Localization (release) of insulin in sympathetic
16) Confidence 0.60 Published 1988 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 3063970 Disease Relevance 0 Pain Relevance 0.13
We investigated the effects of phentolamine and another more selective alpha 2-adrenoceptor antagonist, rauwolscine, on insulin release in vivo (in female Wistar-rats) and in vitro (in perfused rat pancreas and in isolated perifused mouse islets).
Spec (investigated) Regulation (effects) of Localization (release) of insulin in pancreas associated with antagonist
17) Confidence 0.60 Published 1988 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 3063970 Disease Relevance 0 Pain Relevance 0.12
Effect of a phospho-oligosaccharidic putative insulin messenger on insulin release in rats.
Regulation (Effect) of Localization (release) of insulin
18) Confidence 0.60 Published 1989 Journal Diabetologia Section Title Doc Link 2666215 Disease Relevance 0.07 Pain Relevance 0.08
This glucose-induced insulin secretion was maximal at 0.6 mM and was modulated by other secretagogues.
Regulation (modulated) of Localization (secretion) of insulin
19) Confidence 0.59 Published 1990 Journal Endocrinology Section Abstract Doc Link 1701127 Disease Relevance 0 Pain Relevance 0
Modulation of glucose-induced insulin secretion from a rat clonal beta-cell line.
Regulation (Modulation) of Localization (secretion) of insulin
20) Confidence 0.59 Published 1990 Journal Endocrinology Section Title Doc Link 1701127 Disease Relevance 0 Pain Relevance 0.09

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