INT14740

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Context Info
Confidence 0.78
First Reported 1991
Last Reported 2011
Negated 4
Speculated 20
Reported most in Body
Documents 272
Total Number 292
Disease Relevance 168.48
Pain Relevance 60.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TGFB1) enzyme binding (TGFB1) embryo development (TGFB1)
cytoplasm (TGFB1) extracellular space (TGFB1) extracellular region (TGFB1)
Anatomy Link Frequency
articular 9
epithelial cells 8
knees 7
blood 6
macrophages 5
TGFB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 3194 100.00 Very High Very High Very High
cytokine 1562 100.00 Very High Very High Very High
chemokine 305 100.00 Very High Very High Very High
metalloproteinase 223 100.00 Very High Very High Very High
bDMF 60 100.00 Very High Very High Very High
Nerve growth factor 39 100.00 Very High Very High Very High
Dismenorea 10 100.00 Very High Very High Very High
aspirin 709 99.98 Very High Very High Very High
tail-flick 1 99.98 Very High Very High Very High
dexamethasone 75 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3506 100.00 Very High Very High Very High
Death 171 100.00 Very High Very High Very High
Benign Prostatic Hypertrophy 115 100.00 Very High Very High Very High
Prostate Cancer 63 100.00 Very High Very High Very High
Obesity 49 100.00 Very High Very High Very High
Camurati-engelmann Disease 17 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 377 99.96 Very High Very High Very High
Tendinopathy 36 99.92 Very High Very High Very High
Calculi 4 99.92 Very High Very High Very High
Biliary Tract Disease 1 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study investigated the expression of TGF-beta 1 precursor (beta 1 latency-associated peptide), latent TGF-beta 1-binding protein (LTBP), and TGF-beta 1 messenger RNA (mRNA) in chronic pancreatitis.
Spec (investigated) Gene_expression (expression) of TGF-beta associated with chronic pancreatitis
1) Confidence 0.78 Published 1995 Journal Gastroenterology Section Abstract Doc Link 7768393 Disease Relevance 0.37 Pain Relevance 0.27
In chronic pancreatitis, TGF-beta 1 precursor was detected mainly in mononuclear cells located in the fibrotic areas and also in ducts damaged by fibrosis, more frequently in calcifying chronic pancreatitis.
Gene_expression (detected) of TGF-beta 1 precursor in ducts
2) Confidence 0.78 Published 1995 Journal Gastroenterology Section Body Doc Link 7768393 Disease Relevance 0.08 Pain Relevance 0
METHODS: Beta 1 latency-associated peptide and LTBP expression were studied by immunohistochemistry, and TGF-beta 1 mRNA expression was studied by reverse-transcription polymerase chain reaction analysis in normal pancreatic parenchyma and in tissues from patients with chronic pancreatitis of different etiologies.
Gene_expression (expression) of Beta 1 latency-associated peptide in parenchyma
3) Confidence 0.78 Published 1995 Journal Gastroenterology Section Body Doc Link 7768393 Disease Relevance 0.10 Pain Relevance 0
TGF-beta 1 mRNA was either not expressed or was faintly expressed in normal tissue, whereas intense signals were detected in chronic pancreatitis.
Neg (not) Gene_expression (expressed) of TGF-beta 1 mRNA
4) Confidence 0.78 Published 1995 Journal Gastroenterology Section Body Doc Link 7768393 Disease Relevance 0.07 Pain Relevance 0
METHODS: Beta 1 latency-associated peptide and LTBP expression were studied by immunohistochemistry, and TGF-beta 1 mRNA expression was studied by reverse-transcription polymerase chain reaction analysis in normal pancreatic parenchyma and in tissues from patients with chronic pancreatitis of different etiologies.
Gene_expression (expression) of TGF-beta 1 mRNA in parenchyma
5) Confidence 0.78 Published 1995 Journal Gastroenterology Section Body Doc Link 7768393 Disease Relevance 0.10 Pain Relevance 0
This study investigated the expression of TGF-beta 1 precursor (beta 1 latency-associated peptide), latent TGF-beta 1-binding protein (LTBP), and TGF-beta 1 messenger RNA (mRNA) in chronic pancreatitis.
Spec (investigated) Gene_expression (expression) of TGF-beta associated with chronic pancreatitis
6) Confidence 0.78 Published 1995 Journal Gastroenterology Section Abstract Doc Link 7768393 Disease Relevance 0.37 Pain Relevance 0.27
TGF-beta 1 mRNA was either not expressed or was faintly expressed in normal tissue, whereas intense signals were detected in chronic pancreatitis.
Neg (not) Gene_expression (expressed) of TGF-beta 1 mRNA
7) Confidence 0.78 Published 1995 Journal Gastroenterology Section Body Doc Link 7768393 Disease Relevance 0.07 Pain Relevance 0
RESULTS: In normal specimens, TGF-beta 1 precursor was present in islet cells and in a few ductal and acinar cells but not in periductal connective tissue.
Neg (not) Gene_expression (present) of TGF-beta 1 precursor in connective tissue
8) Confidence 0.78 Published 1995 Journal Gastroenterology Section Body Doc Link 7768393 Disease Relevance 0.09 Pain Relevance 0
Exogenous nitric oxide causes overexpression of TGF-beta1 and overproduction of extracellular matrix in human coronary smooth muscle cells.
Gene_expression (overexpression) of TGF-beta1 in smooth muscle cells
9) Confidence 0.78 Published 2003 Journal Cardiovasc. Res. Section Title Doc Link 12798441 Disease Relevance 0 Pain Relevance 0.09
CONCLUSIONS: Our results suggest a dual function of the overexpressed TGF-beta(1).
Gene_expression (overexpressed) of TGF-beta
10) Confidence 0.78 Published 2003 Journal Cardiovasc. Res. Section Body Doc Link 12798441 Disease Relevance 0.12 Pain Relevance 0
Overexpressed TGF-beta(1) could stabilize the fibrous cap overlaying atherosclerotic plaques due to the accumulation of extracellular matrix components.
Gene_expression (Overexpressed) of TGF-beta in extracellular matrix
11) Confidence 0.78 Published 2003 Journal Cardiovasc. Res. Section Body Doc Link 12798441 Disease Relevance 0.12 Pain Relevance 0
RESULTS: Cells exposed to 100 microM DETA/NO for 48-72 h were channeled into a cell cycle-arrested hypertrophic growth status associated with overexpression of TGF-beta(1) on both the protein and mRNA levels.
Gene_expression (overexpression) of TGF-beta
12) Confidence 0.78 Published 2003 Journal Cardiovasc. Res. Section Body Doc Link 12798441 Disease Relevance 0.17 Pain Relevance 0
The aim of our study was to investigate the influence of peritoneal fluid (PF) from endometriosis patients on cultured neural cells that are the morphological basis of nociception, and to determine whether there was a relationship between the rAFS staging and an elevation of TGF-beta1 production by these cells.
Gene_expression (production) of TGF-beta1 in neural associated with nociception and endometriosis
13) Confidence 0.77 Published 2009 Journal Gynecol. Endocrinol. Section Abstract Doc Link 19908949 Disease Relevance 1.10 Pain Relevance 0.71
In the in vitro experiments, cellular responses to LLLT were studied in two cell types: primary cultures of human gingival fibroblasts and human osteoblast-like cells, with special reference to attachment, proliferation, differentiation and production of transforming growth factor beta1 (TGF-beta1).
Gene_expression (production) of transforming growth factor beta1 in osteoblast associated with osteoporosis
14) Confidence 0.77 Published 2005 Journal Swed Dent J Suppl Section Abstract Doc Link 15906852 Disease Relevance 0.26 Pain Relevance 0.05
Osteocalcin synthesis and TGF-beta1 production were significantly stimulated on the samples exposed to 3 J/cm2.
Gene_expression (production) of TGF-beta1
15) Confidence 0.77 Published 2005 Journal Swed Dent J Suppl Section Abstract Doc Link 15906852 Disease Relevance 0.14 Pain Relevance 0
In the in vitro experiments, cellular responses to LLLT were studied in two cell types: primary cultures of human gingival fibroblasts and human osteoblast-like cells, with special reference to attachment, proliferation, differentiation and production of transforming growth factor beta1 (TGF-beta1).
Gene_expression (production) of TGF-beta1 in osteoblast associated with osteoporosis
16) Confidence 0.77 Published 2005 Journal Swed Dent J Suppl Section Abstract Doc Link 15906852 Disease Relevance 0.26 Pain Relevance 0.05
Elevated expression of the genes for transforming growth factor-beta 1 and type VI collagen in diffuse fasciitis associated with the eosinophilia-myalgia syndrome.
Gene_expression (expression) of transforming growth factor-beta 1 associated with pain, syndrome, fasciitis, myalgia and eosinophilia
17) Confidence 0.75 Published 1991 Journal J. Invest. Dermatol. Section Title Doc Link 1702819 Disease Relevance 0.85 Pain Relevance 0.13
Full-thickness skin biopsies obtained from four patients with rapidly progressive diffuse fasciitis associated with the Eosinophilia-Myalgia syndrome (EMS) were examined for the expression of transforming growth factor-beta 1 (TGF-beta 1), type VI collagen, and fibronectin genes employing immunohistochemistry and in situ hybridizations.
Gene_expression (expression) of transforming growth factor-beta 1 in skin associated with syndrome, fasciitis, myalgia and eosinophilia
18) Confidence 0.75 Published 1991 Journal J. Invest. Dermatol. Section Abstract Doc Link 1702819 Disease Relevance 0.80 Pain Relevance 0
Full-thickness skin biopsies obtained from four patients with rapidly progressive diffuse fasciitis associated with the Eosinophilia-Myalgia syndrome (EMS) were examined for the expression of transforming growth factor-beta 1 (TGF-beta 1), type VI collagen, and fibronectin genes employing immunohistochemistry and in situ hybridizations.
Spec (examined) Gene_expression (expression) of TGF-beta in skin associated with syndrome, fasciitis, myalgia and eosinophilia
19) Confidence 0.75 Published 1991 Journal J. Invest. Dermatol. Section Abstract Doc Link 1702819 Disease Relevance 0.80 Pain Relevance 0
Almost all cell types express TGF-?
Gene_expression (express) of TGF
20) Confidence 0.75 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165041 Disease Relevance 0.06 Pain Relevance 0.07

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