INT147412

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 7.57
Pain Relevance 2.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (DRD4) cytoplasm (DRD4) signal transducer activity (DRD4)
DRD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 267 100.00 Very High Very High Very High
depression 40 100.00 Very High Very High Very High
dopamine receptor 48 99.64 Very High Very High Very High
addiction 229 99.60 Very High Very High Very High
alcohol 42 99.12 Very High Very High Very High
fortral 1 98.40 Very High Very High Very High
opioid receptor 6 96.08 Very High Very High Very High
Nicotine 376 87.28 High High
cocaine 10 87.24 High High
drug abuse 42 86.20 High High
Disease Link Frequency Relevance Heat
Depression 44 100.00 Very High Very High Very High
Drug Dependence 82 99.80 Very High Very High Very High
Anxiety Disorder 230 99.60 Very High Very High Very High
Nicotine Addiction 710 99.48 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 266 99.28 Very High Very High Very High
Targeted Disruption 1 87.68 High High
Hypoactive Sexual Desire Disorder 1 84.44 Quite High
Disease 21 84.40 Quite High
Alcohol Addiction 48 77.24 Quite High
Obsessive-compulsive Disorder 9 77.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One meta-analysis has found no overall association between DRD4 48 bp and novelty seeking [48], another a small effect [49] and a third review reports a positive association [50].
DRD4 Neg (no) Binding (association) of
1) Confidence 0.47 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1781951 Disease Relevance 0.62 Pain Relevance 0.04
No significant effects were evident for any of the self-report measures of impulsivity, although a marginally significant interaction effect of DRD2TaqI A and DRD4 VNTR was evident on the SSS Total scale (F (1,177) = 3.52, p = .06, ?
DRD4 VNTR Binding (interaction) of associated with attention deficit hyperactivity disorder
2) Confidence 0.37 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1781951 Disease Relevance 0.29 Pain Relevance 0
There is also support for an association between DRD4 7R+ and multiple/interracial ancestries [39].
DRD4 Binding (association) of
3) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994774 Disease Relevance 0.39 Pain Relevance 0.20
Beyond delay discounting, it was notable that there were no significant genetic associations evident for any of the survey-based self-report measures, with the exception of a trend toward greater sensation seeking reflecting the same DRD2 TaqI A by DRD4 VNTR interaction.
DRD4 VNTR Binding (interaction) of
4) Confidence 0.35 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1781951 Disease Relevance 0.41 Pain Relevance 0
Here, we will review the information collected implicating the receptors of the D1 family (DRD1 and DRD5) and of the D2 family (DRD2, DRD3 and DRD4) in drug addiction.
DRD4 Binding (receptors) of associated with drug dependence and addiction
5) Confidence 0.33 Published 2009 Journal Behav Pharmacol Section Abstract Doc Link 19179847 Disease Relevance 0.59 Pain Relevance 0.55
An unambiguous assay for the cloned human sigma1 receptor reveals high affinity interactions with dopamine D4 receptor selective compounds and a distinct structure-affinity relationship for butyrophenones.
dopamine D4 receptor Binding (interactions) of associated with fortral and dopamine
6) Confidence 0.29 Published 2008 Journal Eur. J. Pharmacol. Section Title Doc Link 17961544 Disease Relevance 0.26 Pain Relevance 0.30
Of note, a recent study simultaneously analyzed linkage and association of the DRD4 genotype to smoking, alcohol and novelty-seeking behaviors in a sibling-pair design [115].
DRD4 Spec (analyzed) Binding (association) of associated with nicotine addiction and alcohol
7) Confidence 0.16 Published 2004 Journal Tob Induc Dis Section Body Doc Link PMC2669467 Disease Relevance 0.72 Pain Relevance 0.11
Of note, a recent study simultaneously analyzed linkage and association of the DRD4 genotype to smoking, alcohol and novelty-seeking behaviors in a sibling-pair design [115].
DRD4 Spec (analyzed) Binding (association) of associated with nicotine addiction and alcohol
8) Confidence 0.16 Published 2004 Journal Tob Induc Dis Section Body Doc Link PMC2671538 Disease Relevance 0.72 Pain Relevance 0.11
In a combined sample, a significant interaction was seen between depression and DRD4, in which depressed smokers homozygous for the short alleles of DRD4 were more likely to smoke to reduce negative feelings and to smoke in response to stimulation [23].
DRD4 Binding (interaction) of associated with nicotine addiction and depression
9) Confidence 0.16 Published 2004 Journal Tob Induc Dis Section Body Doc Link PMC2671538 Disease Relevance 0.79 Pain Relevance 0.32
In a combined sample, a significant interaction was seen between depression and DRD4, in which depressed smokers homozygous for the short alleles of DRD4 were more likely to smoke to reduce negative feelings and to smoke in response to stimulation [23].
DRD4 Binding (interaction) of associated with nicotine addiction and depression
10) Confidence 0.16 Published 2004 Journal Tob Induc Dis Section Body Doc Link PMC2669467 Disease Relevance 0.79 Pain Relevance 0.32
17) group.76 In conclusion, there are still inconsistent results of the association between the DRD4 gene and OCD, but some studies74 (including ours76) suggest the possibility that the 2-repeats allele or a nearby genetic variation could have a protective effect against OCD symptoms.
DRD4 Binding (association) of associated with anxiety disorder
11) Confidence 0.10 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687723 Disease Relevance 1.16 Pain Relevance 0
In a study done with Native American alcoholics, a linkage on chromosome 11 near the DRD4 gene was documented.
DRD4 gene Binding (linkage) of
12) Confidence 0.05 Published 2005 Journal Harm Reduct J Section Body Doc Link PMC1174878 Disease Relevance 0.64 Pain Relevance 0.50
Ropinirole is a non-ergoline derivative with high relative in vitro specificity and full intrinsic activity at the D2 and D3 dopamine receptor subtypes, and it binds with higher affinity to D3 compared with D2 or D4 receptor subtypes.
D4 receptor Binding (binds) of associated with dopamine receptor
13) Confidence 0.01 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671939 Disease Relevance 0.20 Pain Relevance 0.31

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