INT147417

Context Info Confidence 0.46 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 1.69 Pain Relevance 2.20

plasma membrane (Igf1r)

Anatomy Link Frequency hindlimb 2 hippocampus 2 Igf1r (Rattus norvegicus)

Pain Link Frequency Relevance Heat fluoxetine 20 99.98 Hippocampus 6 99.90 antidepressant 4 77.24 Mechanotransduction 1 5.00 Analgesic 1 5.00 Codeine 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Urological Neuroanatomy 14 99.68 Cognitive Disorder 6 91.12 Stress 22 87.88 Injury 10 40.84 Wound Healing 1 29.16 Cicatrix 7 5.00 Sprains And Strains 6 5.00 Body Weight 5 5.00 Hematoma 2 5.00 Adhesions 2 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Acute FLX administration decreased IGF-1 mRNA levels in the FC and hippocampus and increased IGF-1R levels in the FC.

Positive_regulation (increased) of Gene_expression (levels) of IGF-1R in hippocampus associated with urological neuroanatomy, hippocampus and fluoxetine

1) Confidence 0.46 Published 2008 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17961991 Disease Relevance 0.72 Pain Relevance 1.09

Repeated FLX increased both mRNA and IGF-1R levels in the FC.

Positive_regulation (increased) of Gene_expression (levels) of IGF-1R associated with urological neuroanatomy and fluoxetine

2) Confidence 0.46 Published 2008 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17961991 Disease Relevance 0.72 Pain Relevance 1.10

Furthermore, levels of IGF-receptor were significantly increased in tissues from hindlimb unloaded animals treated with IGF-I.

Positive_regulation (increased) of Gene_expression (levels) of IGF-receptor in hindlimb

3) Confidence 0.08 Published 2007 Journal BMC Physiol Section Abstract Doc Link PMC1851714 Disease Relevance 0.25 Pain Relevance 0

General Comments

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