INT147433

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Context Info
Confidence 0.62
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 7.02
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (BRCA2) chromosome organization (BRCA2) nucleolus (BRCA2)
nucleus (BRCA2) cell cycle (BRCA2) DNA binding (BRCA2)
BRCA2 (Homo sapiens)
BRCA2 - N141I (1)
Pain Link Frequency Relevance Heat
Inflammation 2 93.84 High High
Abeta 19 89.96 High High
palliative 6 87.08 High High
Pain 8 65.76 Quite High
cINOD 5 47.28 Quite Low
imagery 34 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
nud 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 405 100.00 Very High Very High Very High
Alzheimer's Dementia 9 100.00 Very High Very High Very High
Targeted Disruption 12 99.88 Very High Very High Very High
Breast Cancer 433 98.28 Very High Very High Very High
Pancreatic Cancer 50 97.72 Very High Very High Very High
Genomic Instability 2 97.40 Very High Very High Very High
Fanconi Anemia 4 95.76 Very High Very High Very High
Chromosomal Instability 2 95.56 Very High Very High Very High
Death 9 94.24 High High
INFLAMMATION 4 93.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The FANCD1, FANCJ and FANCN gene products act downstream of this step.
Gene_expression (products) of FANCD1
1) Confidence 0.62 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397525 Disease Relevance 0.60 Pain Relevance 0
These in vitro results were confirmed by in vivo experiments in transgenic mice expressing the PS2 N141I FAD mutant.
Gene_expression (expressing) of FAD (N141I) associated with targeted disruption and alzheimer's dementia
2) Confidence 0.58 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 17962197 Disease Relevance 0.59 Pain Relevance 0.55
FANCD1 was found to be the BRCA2 gene [13].
Gene_expression (be) of BRCA2
3) Confidence 0.55 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397525 Disease Relevance 0.61 Pain Relevance 0
BRCA2 tumours expressed cyclin D1 and D3, cyclin D kinase (CDK) 4 and the CDK inhibitors, p16, p21, and p27, which were all downregulated in BRCA1.
Gene_expression (expressed) of BRCA2 associated with cancer
4) Confidence 0.39 Published 2006 Journal Proteome Sci Section Body Doc Link PMC1456950 Disease Relevance 1.12 Pain Relevance 0
There has been interest in using immunotherapy for pancreatic cancer based on the identification of mutated oncogenes, such as KRAS, altered tumor suppressor genes, such as TP53, CDKN2A, DPC4, BRCA2, and ERBB2, as well as over-expression of tumor-associated antigens, such as CEA and MUC-1, in pancreatic carcinoma cells [5].
Gene_expression (expression) of BRCA2 associated with cancer and pancreatic cancer
5) Confidence 0.24 Published 2007 Journal J Transl Med Section Body Doc Link PMC2217514 Disease Relevance 1.39 Pain Relevance 0.09
There has been interest in using immunotherapy for pancreatic cancer based on the identification of mutated oncogenes, such as KRAS, altered tumor suppressor genes, such as TP53, CDKN2A, DPC4, BRCA2, and ERBB2, as well as over-expression of tumor-associated antigens, such as CEA and MUC-1, in pancreatic carcinoma cells [5].
Gene_expression (over) of BRCA2 associated with cancer and pancreatic cancer
6) Confidence 0.24 Published 2007 Journal J Transl Med Section Body Doc Link PMC2217514 Disease Relevance 1.34 Pain Relevance 0.09
A phase I trial included 60 patients, 22 of which were carriers of a BRCA1 or BRCA2 mutation and one had a strong family history of BRCA-associated cancer but declined mutational testing [62].
Gene_expression (mutation) of BRCA2 associated with cancer
7) Confidence 0.22 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2814233 Disease Relevance 0.57 Pain Relevance 0
If somatic mutations or epigenetic silencing leads to the absence of either BRCA1 or BRCA2, alternative DNA repair pathways such as nonhomologous end joining are employed; this subsequently results in chromosomal instability and cell death [54].
Neg (absence) Gene_expression (absence) of BRCA2 associated with chromosomal instability and death
8) Confidence 0.20 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2814233 Disease Relevance 0.80 Pain Relevance 0.07

General Comments

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