INT147438

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Context Info
Confidence 0.65
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.97
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nox4) oxidoreductase activity (Nox4) aging (Nox4)
cell morphogenesis (Nox4) endoplasmic reticulum (Nox4) plasma membrane (Nox4)
Anatomy Link Frequency
podocytes 2
PSCs 1
Nox4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 2 98.12 Very High Very High Very High
chemokine 1 85.12 High High
member 8 2 75.04 Quite High
fibrosis 5 68.00 Quite High
Inflammation 5 66.20 Quite High
Bioavailability 4 34.96 Quite Low
tolerance 2 15.84 Low Low
antagonist 2 15.84 Low Low
anesthesia 3 5.00 Very Low Very Low Very Low
Restless leg syndrome 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Focal Segmental Glomerulosclerosis 6 98.20 Very High Very High Very High
Pancreatitis 2 98.12 Very High Very High Very High
Diabetes Mellitus 47 97.84 Very High Very High Very High
Proteinuria 5 96.96 Very High Very High Very High
Nephrosis 4 96.48 Very High Very High Very High
Injury 9 91.80 High High
Primary Sclerosing Cholangitis 1 89.84 High High
Renal Disease 3 78.64 Quite High
Hypertension 17 78.08 Quite High
Fibrosis 6 68.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In in vitro study, PAN significantly increased NOX4 and TRPC6 expression levels in cultured podocytes.
Gene_expression (expression) of NOX4 in podocytes
1) Confidence 0.65 Published 2009 Journal Cell. Physiol. Biochem. Section Abstract Doc Link 19910702 Disease Relevance 0.78 Pain Relevance 0.06
Podocyte effacement, NADPH oxidase subunit NOX4 expression, enzyme activity and TRPC6 expression were significant increased in glomeruli from PAN nephrosis rats.
Gene_expression (expression) of NOX4 in Podocyte associated with nephrosis
2) Confidence 0.65 Published 2009 Journal Cell. Physiol. Biochem. Section Abstract Doc Link 19910702 Disease Relevance 0.86 Pain Relevance 0.08
PSCs expressed key components of NADPH oxidase (p22(phox), p47(phox), NOX1, gp91(phox)/NOX2, NOX4, and NOX activator 1).
Gene_expression (expressed) of NOX4 in PSCs
3) Confidence 0.55 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17962358 Disease Relevance 0.52 Pain Relevance 0.30
Etoh et al. reported that the expression of both Nox4 and p22phox were increased in a STZ-induced model of diabetes [8].
Gene_expression (expression) of Nox4 associated with diabetes mellitus
4) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909910 Disease Relevance 0.42 Pain Relevance 0
Similarly, aldosterone infusion showed elevated renal tissue ROS levels which were associated with increased mRNA expression of p22phox, Nox-4, and gp91phox (10).
Gene_expression (expression) of Nox-4
5) Confidence 0.22 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.39 Pain Relevance 0.03

General Comments

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