INT147451

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Context Info
Confidence 0.61
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.88
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADCYAP1) extracellular region (ADCYAP1) cell-cell signaling (ADCYAP1)
Anatomy Link Frequency
acinar cells 3
pituitary 2
macrophages 1
ADCYAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 3 100.00 Very High Very High Very High
substance P 3 100.00 Very High Very High Very High
Chronic pancreatitis 22 96.12 Very High Very High Very High
Neurotransmitter 1 92.20 High High
Neuropeptide 4 91.04 High High
cytokine 8 88.88 High High
Inflammation 19 81.92 Quite High
Inflammatory response 8 75.00 Quite High
antagonist 4 73.96 Quite High
agonist 1 68.80 Quite High
Disease Link Frequency Relevance Heat
Pancreatitis 26 96.12 Very High Very High Very High
Disease 2 82.28 Quite High
INFLAMMATION 24 81.92 Quite High
Stress 5 53.16 Quite High
Apoptosis 3 25.76 Quite Low
Nociception 2 25.00 Low Low
Systemic Inflammatory Response Syndrome 7 5.00 Very Low Very Low Very Low
Sepsis 7 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low
Infection 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regulation of PACAP expression was studied in coculture systems using macrophages and acinar cells.
Regulation (Regulation) of Gene_expression (expression) of PACAP in acinar cells
1) Confidence 0.61 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17962362 Disease Relevance 0.91 Pain Relevance 0.89
Regulation of PACAP expression was studied in coculture systems using macrophages and acinar cells.
Regulation (Regulation) of in macrophages Gene_expression (expression) of PACAP in acinar cells
2) Confidence 0.21 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17962362 Disease Relevance 0.91 Pain Relevance 0.89
However, none of the tested neuromediators (norepinephrine, acetylcholine, vasoactive intestinal peptide, pituitary adenylate cyclase-activating polypeptide, substance P, and enkephalin) alone or together had any effect on HLA-DR expression (Figure 6).
Regulation (effect) of Gene_expression (expression) of cyclase-activating polypeptide in pituitary associated with enkephalin and substance p
3) Confidence 0.03 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.05 Pain Relevance 0.27

General Comments

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