INT147452

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Context Info
Confidence 0.77
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 14
Total Number 16
Disease Relevance 12.54
Pain Relevance 9.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADCYAP1) extracellular region (ADCYAP1) cell-cell signaling (ADCYAP1)
Anatomy Link Frequency
pituitary 4
plasma 2
neurons 2
PBMC 2
macrophages 1
ADCYAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 28 100.00 Very High Very High Very High
substance P 11 100.00 Very High Very High Very High
Enkephalin 3 100.00 Very High Very High Very High
Chronic pancreatitis 55 99.92 Very High Very High Very High
Migraine 18 98.80 Very High Very High Very High
Inflammation 46 97.84 Very High Very High Very High
Lasting pain 1 97.16 Very High Very High Very High
Eae 3 96.32 Very High Very High Very High
Analgesic 2 94.52 High High
Thermal hyperalgesia 2 94.48 High High
Disease Link Frequency Relevance Heat
Pancreatitis 59 99.92 Very High Very High Very High
Nociception 11 99.58 Very High Very High Very High
Thrombocytopenia 4 99.48 Very High Very High Very High
Diverticulitis 16 99.30 Very High Very High Very High
Apoptosis 6 98.84 Very High Very High Very High
Headache 18 98.80 Very High Very High Very High
Ganglion Cysts 2 98.64 Very High Very High Very High
INFLAMMATION 47 97.84 Very High Very High Very High
Pain 16 96.72 Very High Very High Very High
Inflammatory Pain 1 96.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regulation of PACAP expression was studied in coculture systems using macrophages and acinar cells.
Gene_expression (expression) of PACAP in acinar cells
1) Confidence 0.77 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17962362 Disease Relevance 0.91 Pain Relevance 0.88
Expression of PACAP and its receptors in human CP was analyzed with quantitative RT-PCR, laser-capture microdissection, and immunohistochemistry.
Spec (analyzed) Gene_expression (Expression) of PACAP associated with chronic pancreatitis
2) Confidence 0.77 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17962362 Disease Relevance 0.91 Pain Relevance 0.87
According to laser-capture microdissection and coculture experiments, PBMC also contributed to generation of a PACAP-rich intrapancreatic environment by upregulating PACAP expression in macrophages encountering apoptotic pancreatic acini.
Gene_expression (expression) of PACAP in PBMC associated with apoptosis
3) Confidence 0.77 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17962362 Disease Relevance 0.87 Pain Relevance 1.01
Study 1 - Nerves in colonic resection specimens with either acute diverticulitis (AD, n = 16) or chronic diverticulitis (CD, n = 16) were assessed for neuropeptide expression recording % area staining with protein gene product (PGP9.5), substance P (SP), neuropeptide K (NPK), pituitary adenylate cyclase activating polypeptide (PACAP), vasoactive intestinal polypeptide (VIP) and galanin.
Gene_expression (expression) of PACAP in pituitary associated with neuropeptide, diverticulitis and substance p
4) Confidence 0.75 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19453515 Disease Relevance 1.10 Pain Relevance 0.52
Although nociceptive responses were also attenuated with PACAP 6-38 in a dose-dependent manner in models of chronic inflammatory and persistent pain, no effects on motor performance were observed at analgesic doses.
Gene_expression (attenuated) of PACAP associated with pain, nociception, inflammation, analgesic and lasting pain
5) Confidence 0.65 Published 2008 Journal J Pain Section Abstract Doc Link 18337184 Disease Relevance 1.94 Pain Relevance 1.33
Study 2 - Mucosal histology was normal and PGP9.5 staining was similar between groups however patients with symptomatic diverticular disease demonstrated significantly higher levels of SP, NPK, VIP, PACAP and galanin within the mucosal plexus.
Gene_expression (levels) of PACAP associated with diverticulitis and substance p
6) Confidence 0.65 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19453515 Disease Relevance 0.72 Pain Relevance 0.41
Pituitary adenylate cyclase-activating polypeptide (PACAP) is present in sensory trigeminal neurons and may modulate nociception at different levels of the nervous system.
Gene_expression (present) of PACAP in neurons associated with nociception
7) Confidence 0.60 Published 2010 Journal Neurotherapeutics Section Abstract Doc Link 20430318 Disease Relevance 1.04 Pain Relevance 0.82
RESULTS: Our results revealed that PACAP-38 is present in human plasma, its concentration is relatively stable in healthy volunteers and it is not significantly altered by gender, age, food intake or hormonal cycle in females.
Gene_expression (present) of PACAP in plasma
8) Confidence 0.59 Published 2009 Journal Eur. J. Endocrinol. Section Body Doc Link 19174531 Disease Relevance 0 Pain Relevance 0
The nociceptive status of CP patients correlated with pancreatic PACAP levels and with IL-10 bias of PACAP-exposed CP PBMC.
Gene_expression (levels) of PACAP in PBMC associated with nociception and chronic pancreatitis
9) Confidence 0.59 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17962362 Disease Relevance 0.94 Pain Relevance 0.99
Presence of pituitary adenylate cyclase activating polypeptide-38 in human plasma and milk.
Gene_expression (Presence) of activating polypeptide in plasma
10) Confidence 0.57 Published 2009 Journal Eur. J. Endocrinol. Section Title Doc Link 19174531 Disease Relevance 0.17 Pain Relevance 0.17
Pituitary adenylate cyclase-activating polypeptide (PACAP) is present in sensory trigeminal neurons and may modulate nociception at different levels of the nervous system.
Gene_expression (present) of cyclase-activating polypeptide in neurons associated with nociception
11) Confidence 0.53 Published 2010 Journal Neurotherapeutics Section Abstract Doc Link 20430318 Disease Relevance 1.05 Pain Relevance 0.82
Patients with PACAP overexpression have a mild thrombocytopenia, a normal platelet survival, relatively small platelets and their bone marrow examination reveals almost no mature megakaryocytes.
Gene_expression (overexpression) of PACAP in platelet associated with thrombocytopenia
12) Confidence 0.51 Published 2007 Journal Eur J Pediatr Section Body Doc Link PMC2042511 Disease Relevance 1.62 Pain Relevance 0.04
These cells express pituitary adenylate cyclase-activating peptide (PACAP) which elicits phase shift signals in the SCN.
Gene_expression (express) of pituitary adenylate cyclase-activating peptide in pituitary
13) Confidence 0.41 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2939436 Disease Relevance 0.16 Pain Relevance 0.13
These cells express pituitary adenylate cyclase-activating peptide (PACAP) which elicits phase shift signals in the SCN.
Gene_expression (express) of PACAP in pituitary
14) Confidence 0.41 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2939436 Disease Relevance 0.16 Pain Relevance 0.13
Regulation of PACAP expression was studied in coculture systems using macrophages and acinar cells.
Gene_expression (expression) of PACAP in macrophages
15) Confidence 0.26 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17962362 Disease Relevance 0.91 Pain Relevance 0.88
However, none of the tested neuromediators (norepinephrine, acetylcholine, vasoactive intestinal peptide, pituitary adenylate cyclase-activating polypeptide, substance P, and enkephalin) alone or together had any effect on HLA-DR expression (Figure 6).
Gene_expression (expression) of cyclase-activating polypeptide in pituitary associated with enkephalin and substance p
16) Confidence 0.05 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.05 Pain Relevance 0.27

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