INT147456

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Context Info
Confidence 0.41
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.32
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD80) intracellular (CD80) cell-cell signaling (CD80)
Anatomy Link Frequency
CD86 2
T cell 2
CD80 (Homo sapiens)
Pain Link Frequency Relevance Heat
abatacept 8 99.08 Very High Very High Very High
rheumatoid arthritis 4 97.08 Very High Very High Very High
cytokine 14 80.60 Quite High
Arthritis 8 5.00 Very Low Very Low Very Low
spinal inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 4 97.08 Very High Very High Very High
Chlamydia Infection 88 94.24 High High
Infection 10 91.36 High High
Body Weight 7 87.44 High High
Epstein-barr Virus 18 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
Seronegative Spondarthritis 6 5.00 Very Low Very Low Very Low
Spondylarthropathies 3 5.00 Very Low Very Low Very Low
Low Back Pain 3 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Abatacept is a recombinant soluble fusion protein that inhibits the CD80/CD86:CD28 costimulatory signal required for T cell activation and has demonstrated efficacy in the treatment of rheumatoid arthritis.
Negative_regulation (inhibits) of Positive_regulation (required) of CD80 in T cell associated with rheumatoid arthritis and abatacept
1) Confidence 0.41 Published 2007 Journal J Clin Pharmacol Section Abstract Doc Link 17962428 Disease Relevance 0.34 Pain Relevance 0.39
After 7 days of cultivation in vitro, the cells turned into DCs, as indicated by the loss of CD14 receptors and the upregulation of HLA-DR, CD80 and CD86 receptors (data not shown).
Negative_regulation (loss) of Positive_regulation (upregulation) of CD80 in CD86
2) Confidence 0.05 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064864 Disease Relevance 0.98 Pain Relevance 0.10

General Comments

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