INT147498

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2009
Negated 0
Speculated 2
Reported most in Abstract
Documents 10
Total Number 12
Disease Relevance 3.16
Pain Relevance 7.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRM5) cytoplasm (GRM5) signal transducer activity (GRM5)
Anatomy Link Frequency
nerve 2
CNS 2
Mouse 1
brain 1
embryonic kidney 1
GRM5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate receptor 23 100.00 Very High Very High Very High
Pain 5 100.00 Very High Very High Very High
opioid receptor 44 99.96 Very High Very High Very High
Central nervous system 6 99.92 Very High Very High Very High
Thermal hyperalgesia 6 99.26 Very High Very High Very High
IPN 6 98.76 Very High Very High Very High
agonist 24 98.64 Very High Very High Very High
antagonist 14 98.60 Very High Very High Very High
Enkephalin 4 98.32 Very High Very High Very High
Lasting pain 3 95.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 6 99.26 Very High Very High Very High
Inflammatory Pain 6 98.76 Very High Very High Very High
Pain 5 95.20 Very High Very High Very High
Disease 2 95.00 High High
Nociception 6 94.92 High High
Depression 5 94.56 High High
INFLAMMATION 3 94.44 High High
Anxiety Disorder 5 94.40 High High
Schizophrenia 2 93.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The availability of this mouse mGlu5b receptor-expressing cell line will facilitate in vitro characterization of mGlu5 receptor-selective agonists or antagonists prior to in vivo pharmacologic testing.
Gene_expression (expressing) of mGlu5 associated with antagonist and agonist
1) Confidence 0.75 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17967450 Disease Relevance 0.15 Pain Relevance 0.38
We now describe the cloning of the mouse mGlu5b receptor gene from adult mouse brain and its expression using an ecdysone-inducible system.
Gene_expression (expression) of mGlu5 in brain
2) Confidence 0.75 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17967450 Disease Relevance 0.28 Pain Relevance 0.25
Mouse mGlu5b receptor expression was induced in HEK-293EcR cells by incubation with ponasterone A, an analogue of the insect hormone ecdysone.
Gene_expression (expression) of mGlu5 in Mouse
3) Confidence 0.75 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17967450 Disease Relevance 0.25 Pain Relevance 0.33
Expression of metabotropic glutamate receptor mGluR5 in human dental pulp.
Gene_expression (Expression) of mGluR5 in dental pulp associated with pain and glutamate receptor
4) Confidence 0.75 Published 2009 Journal J Endod Section Title Doc Link 19410084 Disease Relevance 0.50 Pain Relevance 0.60
To investigate whether mGluR5 may mediate the inflammatory pain and thermal hyperalgesia in the dental pulp, we examined the expression of mGluR5 and transient receptor potential vanilloid 1 (TRPV1) in human dental pulp by immunohistochemistry and electron microscopy; mGluR5-immunopositive (+) axons were observed in nerve bundles and branched extensively within the peripheral coronal pulp.
Spec (examined) Gene_expression (expression) of mGluR5 in nerve associated with thermal hyperalgesia and ipn
5) Confidence 0.75 Published 2009 Journal J Endod Section Abstract Doc Link 19410084 Disease Relevance 0.50 Pain Relevance 0.48
Therefore, we studied the functional coupling and desensitization of the micro-opioid receptor (MOR) in human embryonic kidney (HEK) 293 cells which co-express metabotropic glutamate receptor 5 (mGluR5).
Gene_expression (co-express) of mGluR5 in embryonic kidney associated with glutamate receptor and opioid receptor
6) Confidence 0.74 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19162047 Disease Relevance 0 Pain Relevance 0.84
As demonstrated by the D-Ala2,N-MePhe4,Gl-ol5-enkephalin (DAMGO)-induced inhibition of intracellular cAMP level and by binding studies, the co-expression of mGluR5 had no substantial effect on the agonist binding sites and functional coupling of the MOR.
Gene_expression (co-expression) of mGluR5 associated with agonist, opioid receptor and enkephalin
7) Confidence 0.74 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19162047 Disease Relevance 0 Pain Relevance 0.95
INTRODUCTION: The metabotropic glutamate receptor subtype 5 (mGluR5) is distributed throughout the central nervous system (CNS), and has been suggested to be a potential target for several CNS disorders suchas Parkinson's disease, pain, anxiety, depression, schizophrenia, and addiction.
Gene_expression (distributed) of mGluR5 in CNS associated with addiction, pain, depression, glutamate receptor, anxiety disorder, central nervous system, disease and schizophrenia
8) Confidence 0.65 Published 2008 Journal Nucl Med Commun Section Abstract Doc Link 18769310 Disease Relevance 0.47 Pain Relevance 0.42
INTRODUCTION: The metabotropic glutamate receptor subtype 5 (mGluR5) is distributed throughout the central nervous system (CNS), and has been suggested to be a potential target for several CNS disorders suchas Parkinson's disease, pain, anxiety, depression, schizophrenia, and addiction.
Gene_expression (metabotropic) of mGluR5 in CNS associated with addiction, pain, depression, glutamate receptor, anxiety disorder, central nervous system, disease and schizophrenia
9) Confidence 0.65 Published 2008 Journal Nucl Med Commun Section Abstract Doc Link 18769310 Disease Relevance 0.47 Pain Relevance 0.42
As a mechanistic basis for the observed effects we suggested an interaction/heterodimerization of MOR and mGluR5, which is supported by the DAMGO-induced co-internalization of MOR and mGluR5 and by the increase of MPEP binding sites (Bmax) and a change of the binding affinity (K(D)) of mGluR5 receptors after the co-expression of MOR.
Gene_expression (expression) of mGluR5 associated with opioid receptor
10) Confidence 0.64 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19162047 Disease Relevance 0 Pain Relevance 0.93
However, in MOR/ mGluR5 co-expressing cells, the non-competitive mGluR5 antagonist MPEP (2-methyl-6-(phenyl-ethynyl)-pyridine) decreases the DAMGO-induced MOR phosphorylation, internalization, and desensitization, whereas non-selective competitive mGluR antagonists or agonists had no effects.
Gene_expression (expressing) of mGluR5 associated with antagonist, agonist and opioid receptor
11) Confidence 0.58 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19162047 Disease Relevance 0 Pain Relevance 1.00
To investigate whether mGluR5 may mediate the inflammatory pain and thermal hyperalgesia in the dental pulp, we examined the expression of mGluR5 and transient receptor potential vanilloid 1 (TRPV1) in human dental pulp by immunohistochemistry and electron microscopy; mGluR5-immunopositive (+) axons were observed in nerve bundles and branched extensively within the peripheral coronal pulp.
Spec (examined) Gene_expression (expression) of mGluR5 in nerve associated with thermal hyperalgesia and ipn
12) Confidence 0.57 Published 2009 Journal J Endod Section Abstract Doc Link 19410084 Disease Relevance 0.52 Pain Relevance 0.51

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