INT147505

Context Info Confidence 0.27 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.81 Pain Relevance 0.92

cell proliferation (Gdnf) extracellular space (Gdnf) extracellular region (Gdnf) molecular_function (Ret)

Anatomy Link Frequency neural 1 Ret (Rattus norvegicus) Gdnf (Rattus norvegicus)

Pain Link Frequency Relevance Heat Analgesic 8 98.12 cINOD 1 90.72 Neuropathic pain 3 89.84 opiate 1 89.04 analgesia 1 75.00 spinal dorsal horn 1 62.88 Root ganglion neuron 1 60.24 Lasting pain 1 38.16 neuralgia 3 25.00 Intractable pain 1 25.00

Disease Link Frequency Relevance Heat Adhesions 2 99.44 Nociception 1 95.72 INFLAMMATION 1 90.48 Neuropathic Pain 3 89.84 Injury 4 68.88 Ganglion Cysts 1 59.84 Pain 1 38.16 Intractable Pain 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Glial cell line-derived neurotrophic factor (GDNF) has a variety of functions affecting the survival and development of specified neural cell populations, mediated via transmission of intracellular signals through binding to its high-affinity receptor, GFR*1, and subsequent activation of a tyrosine receptor kinase, RET, neural cell adhesion molecule (NCAM), or other signaling molecules.

RET Binding (binding) of GDNF in neural associated with adhesions

1) Confidence 0.27 Published 2008 Journal Pain Section Abstract Doc Link 17967506 Disease Relevance 0.81 Pain Relevance 0.92

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