INT147518

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.59
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
Anatomy Link Frequency
follicles 2
CAR 2
Ppara (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 130 100.00 Very High Very High Very High
Potency 17 98.40 Very High Very High Very High
antagonist 13 94.96 High High
metalloproteinase 59 90.88 High High
ischemia 5 83.44 Quite High
Paracetamol 3 77.80 Quite High
Inflammation 23 15.24 Low Low
Inflammatory response 7 12.88 Low Low
cINOD 19 5.00 Very Low Very Low Very Low
Osteoarthritis 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 12 100.00 Very High Very High Very High
Stroke 5 99.92 Very High Very High Very High
Apoptosis 78 99.82 Very High Very High Very High
Renal Disease 3 99.44 Very High Very High Very High
Myocardial Infarction 10 98.80 Very High Very High Very High
Metabolic Syndrome 17 98.76 Very High Very High Very High
Benign Tumor 3 98.64 Very High Very High Very High
Diabetes Mellitus 14 98.30 Very High Very High Very High
Pressure And Volume Under Development 20 97.56 Very High Very High Very High
Ovarian Cancer 27 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some of the synthetic agonists of PPAR?
Regulation (Some) of Gene_expression (agonists) of PPAR associated with agonist
1) Confidence 0.42 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 1.44 Pain Relevance 0.12
Mice with targeted knockout of the PPAR-?
Regulation (targeted) of Gene_expression (knockout) of PPAR associated with targeted disruption
2) Confidence 0.39 Published 2009 Journal PPAR Research Section Body Doc Link PMC2696219 Disease Relevance 1.15 Pain Relevance 0.03
to evaluate the involvement of PPAR isotype in the anti-TGF-?
Regulation (involvement) of Gene_expression (isotype) of PPAR
3) Confidence 0.38 Published 2010 Journal PPAR Research Section Body Doc Link PMC2957135 Disease Relevance 0 Pain Relevance 0.44
Taken together, these results indicate that nutritional status may gender-specifically influence the expression and activation of CAR and PPARalpha in liver cell nuclei, and this effect appears to be associated with alterations in UGT1A1 and UGT1A6 expression.
Regulation (influence) of Gene_expression (expression) of PPARalpha in CAR
4) Confidence 0.16 Published 2008 Journal Drug Metab. Dispos. Section Abstract Doc Link 17967931 Disease Relevance 0 Pain Relevance 0.28
For example, the gene encoding bcl-2, an anti-apoptotic factor, has a PPRE, and transfection of PPAR?
Regulation (has) of Gene_expression (transfection) of PPAR associated with apoptosis
5) Confidence 0.15 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0.64 Pain Relevance 0.04
There were no differences found in the number of primordial, primary, or preantral/antral follicles, size of copora lutea, or response to exogenous gonadotropins between control animals and those with PPAR?
Regulation (control) of Gene_expression (those) of PPAR in follicles
6) Confidence 0.15 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0.05 Pain Relevance 0
A study investigating the relationship between the expression of PPAR?
Spec (investigating) Regulation (relationship) of Gene_expression (expression) of PPAR
7) Confidence 0.15 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0.94 Pain Relevance 0.03
In conclusion, our findings suggested that Inslow, which contains palatinose, was an effective functional food for the prevention and treatment of obesity, diabetes and metabolic syndrome because it can maintain the glucose and lipid homeostasis by regulating the expression of the hepatic PPAR-?
Regulation (regulating) of Gene_expression (expression) of PPAR associated with diabetes mellitus and metabolic syndrome
8) Confidence 0.15 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275770 Disease Relevance 0.36 Pain Relevance 0.03

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