INT147522

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 15.82
Pain Relevance 3.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ppara) nucleus (Ppara) DNA binding (Ppara)
Anatomy Link Frequency
adipocyte 4
chondrocytes 2
diaphragm 2
fat 2
granulosa cells 2
Ppara (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 282 99.84 Very High Very High Very High
cva 6 99.70 Very High Very High Very High
Potency 108 98.24 Very High Very High Very High
antagonist 36 96.76 Very High Very High Very High
Inflammation 253 94.80 High High
cytokine 51 88.64 High High
Arthritis 130 87.68 High High
cINOD 42 85.12 High High
ischemia 10 71.80 Quite High
Inflammatory stimuli 12 66.40 Quite High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 9 99.70 Very High Very High Very High
Apoptosis 164 99.50 Very High Very High Very High
Hypersensitivity 53 99.12 Very High Very High Very High
Hepatocellular Cancer 52 99.12 Very High Very High Very High
Obesity 203 98.24 Very High Very High Very High
Hypoxia 46 98.08 Very High Very High Very High
Cirrhosis 32 98.08 Very High Very High Very High
Fatigue 34 97.84 Very High Very High Very High
Diabetes Mellitus 222 97.44 Very High Very High Very High
Hyperlipidemia 17 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
upregulation by PPAR?
Positive_regulation (upregulation) of Gene_expression (by) of PPAR
1) Confidence 0.47 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 1.06 Pain Relevance 0.34
First, in vitro studies demonstrated that PPAR?
Positive_regulation (demonstrated) of Gene_expression (demonstrated) of PPAR
2) Confidence 0.44 Published 2008 Journal PPAR Research Section Body Doc Link PMC2519140 Disease Relevance 0.11 Pain Relevance 0
were used as positive controls for PPAR?
Positive_regulation (used) of Gene_expression (controls) of PPAR
3) Confidence 0.44 Published 2008 Journal PPAR Research Section Body Doc Link PMC2519140 Disease Relevance 0 Pain Relevance 0.03
On the other hand, cerebral infarction is rescued by overexpression of PPAR?.
Positive_regulation (overexpression) of Gene_expression (overexpression) of PPAR associated with cva
4) Confidence 0.43 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 0.94 Pain Relevance 0.29
, whereas increased PPAR?
Positive_regulation (whereas) of Gene_expression (whereas) of PPAR
5) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2900215 Disease Relevance 1.07 Pain Relevance 0.03
activator distinctively induced expression of PPAR?
Positive_regulation (induced) of Gene_expression (expression) of PPAR
6) Confidence 0.41 Published 2008 Journal PPAR Research Section Body Doc Link PMC2519140 Disease Relevance 0.13 Pain Relevance 0
Although OA-NO2 is a robust PPAR?
Positive_regulation (robust) of Gene_expression (Although) of PPAR
7) Confidence 0.40 Published 2010 Journal PPAR Research Section Body Doc Link PMC2910468 Disease Relevance 0.54 Pain Relevance 0.20
Although OA-NO2 is a robust PPAR?
Positive_regulation (robust) of Gene_expression (is) of PPAR
8) Confidence 0.40 Published 2010 Journal PPAR Research Section Body Doc Link PMC2910468 Disease Relevance 0.54 Pain Relevance 0.20
In conclusion, in rat diaphragm, diabetes type I induced complex mechanical and energetic changes, associated with improved resistances to fatigue and hypoxic condition that may be explained mainly by a shift towards slow MHC isoforms associated with an increased expression of PPAR?
Positive_regulation (increased) of Gene_expression (expression) of PPAR in diaphragm associated with hypoxia, diabetes mellitus and fatigue
9) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2900215 Disease Relevance 0.88 Pain Relevance 0
Immunohistochemistry results revealed PPAR?
Positive_regulation (revealed) of Gene_expression (revealed) of PPAR
10) Confidence 0.38 Published 2008 Journal PPAR Research Section Body Doc Link PMC2519140 Disease Relevance 0.16 Pain Relevance 0
activation, mRNA expression of PPAR?
Positive_regulation (activation) of Gene_expression (expression) of PPAR
11) Confidence 0.36 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2846940 Disease Relevance 0.60 Pain Relevance 0.04
Expression of hepatic UDP-glucuronosyltransferase 1A1 and 1A6 correlated with increased expression of the nuclear constitutive androstane receptor and peroxisome proliferator-activated receptor alpha in male rats fed a high-fat and high-sucrose diet.
Positive_regulation (increased) of Gene_expression (expression) of proliferator-activated receptor alpha in fat
12) Confidence 0.35 Published 2008 Journal Drug Metab. Dispos. Section Title Doc Link 17967931 Disease Relevance 0 Pain Relevance 0.18
Therefore, finding a food source or a nutrient capable of activating the functions of both PPAR-?
Positive_regulation (activating) of Gene_expression (functions) of PPAR
13) Confidence 0.31 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275770 Disease Relevance 0.79 Pain Relevance 0
Therefore, we suggest that Inslow promotes insulin–sparing effect, increases the number of small adipocyte, and increases the expression of the PPAR-?
Positive_regulation (increases) of Gene_expression (expression) of PPAR in adipocyte
14) Confidence 0.31 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275770 Disease Relevance 0.58 Pain Relevance 0.04
to induce adipocyte differentiation [48], because we demonstrated that both TZDs stimulated the expression of adiponectin, a PPAR-?
Positive_regulation (stimulated) of Gene_expression (expression) of PPAR in adipocyte
15) Confidence 0.30 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374462 Disease Relevance 1.14 Pain Relevance 0.15
Rosiglitazone 10 mg/kg/day or pioglitazone 30 mg/kg/day increased the expression of PPAR-?
Positive_regulation (increased) of Gene_expression (expression) of PPAR
16) Confidence 0.28 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2374462 Disease Relevance 1.07 Pain Relevance 0.28
As a corollary, the efficient overexpression of PPAR?
Positive_regulation (overexpression) of Gene_expression (overexpression) of PPAR
17) Confidence 0.24 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.07 Pain Relevance 0.21
on the periovulatory period could be done by overexpressing PPAR?
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of PPAR
18) Confidence 0.24 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0.39 Pain Relevance 0
For example, the gene encoding bcl-2, an anti-apoptotic factor, has a PPRE, and transfection of PPAR?
Positive_regulation (transfection) of Gene_expression (transfection) of PPAR associated with apoptosis
19) Confidence 0.24 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1266036 Disease Relevance 0.64 Pain Relevance 0.04
M 15d-PGJ2 was not impaired in cells overexpressing PPAR?
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of PPAR
20) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0 Pain Relevance 0.07

General Comments

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