INT147542

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Context Info
Confidence 0.59
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.63
Pain Relevance 3.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpa1) transmembrane transport (Trpa1)
Anatomy Link Frequency
Ovary 2
Trpa1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 17 99.80 Very High Very High Very High
antagonist 2 98.70 Very High Very High Very High
dorsal root ganglion 19 97.72 Very High Very High Very High
TRP channel 7 97.72 Very High Very High Very High
imagery 17 97.62 Very High Very High Very High
Pain 34 95.48 Very High Very High Very High
Hyperalgesia 70 93.08 High High
Inflammation 29 66.12 Quite High
nociceptor 14 59.48 Quite High
Neuropathic pain 3 47.16 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 19 97.72 Very High Very High Very High
Targeted Disruption 12 96.60 Very High Very High Very High
Pain 27 95.48 Very High Very High Very High
Nociception 47 93.44 High High
Hyperalgesia 79 93.08 High High
INFLAMMATION 29 66.12 Quite High
Injury 6 52.32 Quite High
Neuropathic Pain 9 47.16 Quite Low
Burns 3 41.48 Quite Low
Inflammatory Pain 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TRPA1 antagonists camphor and gadolinium, and a general TRP blocker ruthenium red inhibited TRPA1 activation by acetaldehyde.
Negative_regulation (inhibited) of Positive_regulation (activation) of TRPA1 associated with antagonist
1) Confidence 0.59 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17970723 Disease Relevance 0.39 Pain Relevance 0.38
Cysteine-reducing agents suppressed H(2)O(2)-induced TRPA1 activation, whereas cysteine-oxidizing agents activated TRPA1.
Negative_regulation (suppressed) of Positive_regulation (activation) of TRPA1
2) Confidence 0.59 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18364033 Disease Relevance 0.26 Pain Relevance 0.34
In support of specific activation of TRPA1, 100 ?
Negative_regulation (support) of Positive_regulation (activation) of TRPA1
3) Confidence 0.37 Published 2008 Journal Mol Pain Section Body Doc Link PMC2515828 Disease Relevance 0.58 Pain Relevance 0.58
Using a Fluorometric Imaging Plate Reader (FLIPR, Molecular Devices) calcium-influx assay, we screened 43,648 small molecules for their ability to block cinnamaldehyde-activation of human TRPA1 in a Chinese Hamster Ovary (CHO) cell line.
Negative_regulation (block) of Positive_regulation (activation) of TRPA1 in Ovary associated with imagery
4) Confidence 0.18 Published 2007 Journal Mol Pain Section Body Doc Link PMC2222610 Disease Relevance 0.48 Pain Relevance 0.54
Ruthenium red, gadolinium, menthol, and camphor can inhibit TRPA1 activation, but also interact with other channels, including other TRP channels[18].
Negative_regulation (inhibit) of Positive_regulation (activation) of TRPA1 associated with trp channel
5) Confidence 0.18 Published 2007 Journal Mol Pain Section Body Doc Link PMC2222610 Disease Relevance 0.65 Pain Relevance 0.77
AP18 blocked activation of TRPA1 by 50 ?
Negative_regulation (blocked) of Positive_regulation (activation) of TRPA1
6) Confidence 0.18 Published 2007 Journal Mol Pain Section Body Doc Link PMC2222610 Disease Relevance 0.27 Pain Relevance 0.39

General Comments

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