INT147543

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.24
Pain Relevance 2.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpa1) transmembrane transport (Trpa1)
Anatomy Link Frequency
sensory neurons 2
neurons 2
paw 2
Trpa1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 82 98.76 Very High Very High Very High
dorsal root ganglion 19 98.72 Very High Very High Very High
antagonist 19 98.00 Very High Very High Very High
agonist 48 97.48 Very High Very High Very High
c fibre 2 94.24 High High
withdrawal 33 93.96 High High
depression 1 93.32 High High
Pain 54 90.32 High High
Antinociceptive 1 78.32 Quite High
TRP channel 30 77.00 Quite High
Disease Link Frequency Relevance Heat
Nociception 63 100.00 Very High Very High Very High
Hypersensitivity 63 99.76 Very High Very High Very High
Ganglion Cysts 22 98.72 Very High Very High Very High
Stress 4 95.92 Very High Very High Very High
Respiratory Failure 1 93.32 High High
Pain 58 88.68 High High
INFLAMMATION 30 63.64 Quite High
Targeted Disruption 16 61.04 Quite High
Necrosis 1 38.12 Quite Low
Cancer 2 37.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cysteine-reducing agents suppressed H(2)O(2)-induced TRPA1 activation, whereas cysteine-oxidizing agents activated TRPA1.
Positive_regulation (induced) of Positive_regulation (activation) of TRPA1
1) Confidence 0.69 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18364033 Disease Relevance 0.25 Pain Relevance 0.33
Collectively, the present findings demonstrate that the TRPA1 agonist allyl isothiocyanate produces a consistent nociceptive response when injected into the mouse paw, an effect that seems to be mediated via activation of TRPA1 receptor and dependent on the capsaicin-sensitive fibers, release of histamine by mast cells and participation of tachykinins.
Positive_regulation (mediated) of Positive_regulation (activation) of TRPA1 in paw associated with nociception, qutenza and agonist
2) Confidence 0.69 Published 2008 Journal Neuroscience Section Abstract Doc Link 18272293 Disease Relevance 0.54 Pain Relevance 0.77
We therefore tested whether these residues are required for NO activation of TRPA1.
Neg (NO) Spec (whether) Positive_regulation (required) of Neg (NO) Spec (whether) Positive_regulation (activation) of TRPA1
3) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764051 Disease Relevance 0 Pain Relevance 0.10
In addition, our study showed that two other heavy metals, cadmium and copper, also stimulated pulmonary sensory neurons via a direct activation of TRPA1.
Positive_regulation (stimulated) of Positive_regulation (activation) of TRPA1 in sensory neurons
4) Confidence 0.50 Published 2010 Journal J. Appl. Physiol. Section Abstract Doc Link 20133428 Disease Relevance 0.16 Pain Relevance 0.33
Whether icilin activation of TRPA1 can also induce cold hypersensitivity is unknown.
Positive_regulation (induce) of Positive_regulation (activation) of TRPA1 associated with hypersensitivity
5) Confidence 0.49 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.35 Pain Relevance 0.16
These results suggest that acetaldehyde causes nociception via TRPA1 activation.
Positive_regulation (causes) of Positive_regulation (activation) of TRPA1 associated with nociception
6) Confidence 0.47 Published 2007 Journal Eur. J. Neurosci. Section Abstract Doc Link 17970723 Disease Relevance 0.41 Pain Relevance 0.38
Consistent with a physiological role of 15d-PGJ2 in the activation of TRPA1, we identified a population of DRG neurons sensitive to 15d-PGJ2, AITC and capsaicin.
Positive_regulation (role) of Positive_regulation (activation) of TRPA1 in neurons associated with dorsal root ganglion and qutenza
7) Confidence 0.44 Published 2008 Journal Mol Pain Section Body Doc Link PMC2515828 Disease Relevance 0.40 Pain Relevance 0.22
Whether these effects are mediated solely through TRPA1 activation remains unclear, since both TRPM8 and TRPV1 are also activated by these compounds.
Positive_regulation (mediated) of Positive_regulation (activation) of TRPA1
8) Confidence 0.39 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645550 Disease Relevance 0.13 Pain Relevance 0.10

General Comments

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