INT147554

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 10.93
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Birc2) intracellular (Birc2) protein complex (Birc2)
cytoplasm (Birc2)
Anatomy Link Frequency
blood 2
bowel 2
Birc2 (Mus musculus)
Pain Link Frequency Relevance Heat
spastic colon 2 99.68 Very High Very High Very High
Inflammation 39 97.92 Very High Very High Very High
cytokine 54 72.00 Quite High
positron emission tomography 32 47.20 Quite Low
corticosteroid 10 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
lidocaine 6 5.00 Very Low Very Low Very Low
alcohol 5 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 506 100.00 Very High Very High Very High
Functional Bowel Disorder 2 99.68 Very High Very High Very High
Disease 42 98.30 Very High Very High Very High
Hypersensitivity 30 98.28 Very High Very High Very High
INFLAMMATION 37 97.92 Very High Very High Very High
Inflammatory Bowel Disease 20 96.56 Very High Very High Very High
Death 94 96.54 Very High Very High Very High
Nasal Polyps 6 91.96 High High
Cancer 262 89.84 High High
Lung Cancer 128 84.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fourteen patients with active UC and 12 control subjects who underwent routine colonoscopy for control of their disease or as part of their examination program for irritable bowel syndrome were included. cIAP1 and cIAP2 expression was investigated by polymerase chain reaction, Western blotting, and immunohistochemistry.
Gene_expression (expression) of cIAP2 in bowel associated with inflammatory bowel disease, spastic colon and disease
1) Confidence 0.75 Published 2007 Journal Virchows Arch. Section Abstract Doc Link 17972100 Disease Relevance 1.25 Pain Relevance 0.17
Fourteen patients with active UC and 12 control subjects who underwent routine colonoscopy for control of their disease or as part of their examination program for irritable bowel syndrome were included. cIAP1 and cIAP2 expression was investigated by polymerase chain reaction, Western blotting, and immunohistochemistry.
Gene_expression (expression) of cIAP1 in bowel associated with inflammatory bowel disease, spastic colon and disease
2) Confidence 0.65 Published 2007 Journal Virchows Arch. Section Abstract Doc Link 17972100 Disease Relevance 1.25 Pain Relevance 0.17
Overexpression of inhibitor of apoptosis (IAP) family members (IAP-2 among them) can also inhibit caspase activation, block apoptosis, and increase drug resistance [28].
Gene_expression (Overexpression) of IAP-2 associated with apoptosis
3) Confidence 0.22 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 1.29 Pain Relevance 0
B to increase the expression of cIAP2 [64].
Gene_expression (expression) of cIAP2
4) Confidence 0.18 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.27 Pain Relevance 0
In the context of enhanced mitochondria triggered cell death due to disrupted mitochondrial transmembrane potential we detected the release of cytochrome-c, AIF and Smac/Diabolo into the cytoplasm, decreased levels of anti-apoptotoc c-IAP1 and c-IAP2 but unchanged levels of XIAP.
Neg (unchanged) Gene_expression (levels) of c-IAP1 associated with death
5) Confidence 0.17 Published 2006 Journal J Carcinog Section Body Doc Link PMC1665446 Disease Relevance 0.90 Pain Relevance 0
Therefore, the ability of lapatinib to reduce the levels of Bcl-xL and IAP-2 should increase mitochondria outer membrane permeabilization (MOMP), release cytochrome-C, and induce apoptosis.
Gene_expression (levels) of IAP-2 associated with apoptosis
6) Confidence 0.17 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 1.28 Pain Relevance 0
Lapatinib reduced the levels of the two antiapoptotic proteins IAP-2 and Bcl-xL, and increased the levels of the proapoptotic protein Bak-1.
Gene_expression (levels) of IAP-2
7) Confidence 0.17 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 0.41 Pain Relevance 0
Moreover, lapatinib decreased levels of the anti-apoptotic proteins Bcl-xL and IAP-2.
Gene_expression (levels) of IAP-2 associated with apoptosis
8) Confidence 0.17 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2883966 Disease Relevance 1.06 Pain Relevance 0
In the context of enhanced mitochondria triggered cell death due to disrupted mitochondrial transmembrane potential we detected the release of cytochrome-c, AIF and Smac/Diabolo into the cytoplasm, decreased levels of anti-apoptotoc c-IAP1 and c-IAP2 but unchanged levels of XIAP.
Neg (unchanged) Gene_expression (levels) of c-IAP2 associated with death
9) Confidence 0.08 Published 2006 Journal J Carcinog Section Body Doc Link PMC1665446 Disease Relevance 0.90 Pain Relevance 0
CD40 engagement also enhances eosinophil survival through induction of cellular inhibitor of apoptosis protein 2 (c-IAP2) expression and suggests a role for this mechanism in allergic inflammation.79 CD40 was not expressed on freshly-isolated blood eosinophils, but was seen following culture.


Gene_expression (expression) of c-IAP2 in blood associated with inflammation, hypersensitivity and apoptosis
10) Confidence 0.06 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 1.15 Pain Relevance 0.14
CD40 engagement also enhances eosinophil survival through induction of cellular inhibitor of apoptosis protein 2 (c-IAP2) expression and suggests a role for this mechanism in allergic inflammation.79 CD40 was not expressed on freshly-isolated blood eosinophils, but was seen following culture.


Gene_expression (expression) of apoptosis protein 2 in blood associated with inflammation, hypersensitivity and apoptosis
11) Confidence 0.06 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 1.16 Pain Relevance 0.14

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