INT147572

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 73
Total Number 74
Disease Relevance 38.99
Pain Relevance 3.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

immune system process (Ahr) cell morphogenesis (Ahr) DNA binding (Ahr)
response to stress (Ahr) cytoplasm (Ahr) signal transducer activity (Ahr)
Anatomy Link Frequency
neural 7
brain 4
eosinophils 4
epithelium 3
CAR 1
Ahr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 360 100.00 Very High Very High Very High
cytokine 144 100.00 Very High Very High Very High
agonist 55 100.00 Very High Very High Very High
nMDA receptor 2 97.24 Very High Very High Very High
Inflammatory response 12 94.96 High High
withdrawal 33 87.20 High High
Neurotransmitter 205 85.44 High High
Inflammatory mediators 5 79.84 Quite High
midbrain 41 79.16 Quite High
Action potential 1 77.36 Quite High
Disease Link Frequency Relevance Heat
Asthma 504 100.00 Very High Very High Very High
INFLAMMATION 362 100.00 Very High Very High Very High
Sprains And Strains 110 100.00 Very High Very High Very High
Repression 45 100.00 Very High Very High Very High
Occupational Lung Diseases 42 100.00 Very High Very High Very High
Drug Induced Neurotoxicity 290 99.80 Very High Very High Very High
Hypersensitivity 175 99.80 Very High Very High Very High
Cancer 580 99.68 Very High Very High Very High
Airway Obstruction 46 99.68 Very High Very High Very High
Neuroblastoma 369 99.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is based on the finding that the increase of CYP1A1 mRNA expression caused by over-expression of exogenous AhR was clearly suppressed by repression of the AhR with siRNA.
Gene_expression (expression) of AhR associated with repression
1) Confidence 0.75 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.49 Pain Relevance 0
The dioxin receptor, namely the AhR, is expressed in various regions of the brain [18,19] during the critical period of brain development [20,21].
Gene_expression (expressed) of dioxin receptor in brain
2) Confidence 0.75 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.14 Pain Relevance 0.04
Two siRNAs, si-AhR and scramble, were synthesized (Qiagen KK) and transfected into the cells using RNAiFect according to the manufacturer's instructions (Qiagen KK).
Gene_expression (synthesized) of AhR
3) Confidence 0.75 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0 Pain Relevance 0.05
Neruo2a cells transfected with AhR, named N2a-R?
Gene_expression (transfected) of AhR
4) Confidence 0.75 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.29 Pain Relevance 0
There have been several other examples in which transfected AhR has been found to be active in the host cells [56,57], although it remains unclear why ligand-dependent AhR is activated under conditions in the absence of either ligand or TCDD.
Gene_expression (transfected) of AhR
5) Confidence 0.75 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.50 Pain Relevance 0.03
In particular, it has been reported that maximal expression of AhR protein was observed during P3–10 [22].
Gene_expression (expression) of AhR
6) Confidence 0.75 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.20 Pain Relevance 0.04
These results suggest that the transfected AhR was expressed and functional in the N2a-R?
Gene_expression (expressed) of AhR
7) Confidence 0.75 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0 Pain Relevance 0
As such, CYP1A1, GST and AhRR mRNA would be induced if functional AhR is expressed in N2a-R?.
Gene_expression (expressed) of AhR
8) Confidence 0.75 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0 Pain Relevance 0
In this study, we have shown that over-expression of AhR caused neural differentiation of Neuro2a cells.
Gene_expression (over) of AhR in neural
9) Confidence 0.75 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.23 Pain Relevance 0
The dioxin receptor, namely the AhR, is expressed in various regions of the brain [18,19] during the critical period of brain development [20,21].
Gene_expression (expressed) of AhR in brain
10) Confidence 0.75 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.14 Pain Relevance 0.04
, may mimic the neurons forming the neural network during the perinatal stages, expressing AhR in the presence of the ligand.
Gene_expression (expressing) of AhR in neural
11) Confidence 0.75 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.31 Pain Relevance 0
We detected high AhR expression and activation in basal cells and atrophic epithelial cells of human cancer bearing prostates.
Gene_expression (expression) of AhR in epithelial cells associated with cancer
12) Confidence 0.69 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2816705 Disease Relevance 0.78 Pain Relevance 0
Our studies indicate a novel ligand independent strategy of boosting AhR expression as means of suppressing prostate cancer growth.
Gene_expression (expression) of AhR associated with prostate cancer
13) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 0.95 Pain Relevance 0.10
We found that AhR is normally expressed at low levels in the prostatic epithelium basal cells (cytoplasmic and nuclear staining, Figure 6A) and is substantially upregulated in areas of proliferative inflammatory atrophy (PIA), considered a precursor lesion to cancer (Figure 6B).
Gene_expression (expressed) of AhR in epithelium associated with inflammation, cancer and frailty
14) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 1.04 Pain Relevance 0.12
We performed immunohitochemical anti AhR staining and monitored cytoplasmatic and nuclear AhR expression.
Gene_expression (expression) of AhR
15) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 1.12 Pain Relevance 0.04
AhR expression and activation is also significantly higher in tumor cells compared to benign glandular epithelium.


Gene_expression (expression) of AhR in epithelium associated with cancer
16) Confidence 0.69 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2816705 Disease Relevance 0.77 Pain Relevance 0
On the other hand boosting AhR expression via ?
Gene_expression (expression) of AhR
17) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 0.59 Pain Relevance 0.04
Responses of DRESSA mice to AhR agonists
Gene_expression (agonists) of AhR associated with agonist
18) Confidence 0.67 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.08 Pain Relevance 0.08
Using the same gene construct (Figure 1A), we generated transgenic sensor mice DRESSA that can produce SEAP under the control of AhR.
Gene_expression (produce) of AhR associated with targeted disruption
19) Confidence 0.67 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.42 Pain Relevance 0
AhR, CYP1A1 and cdc42 mRNA expression were quantified in AhR by real-time PCR.
Gene_expression (expression) of AhR
20) Confidence 0.65 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0 Pain Relevance 0

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