INT147574

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.40
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Scrg1)
Anatomy Link Frequency
neuronal 1
Scrg1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 210 100.00 Very High Very High Very High
Calcitonin gene-related peptide 21 99.96 Very High Very High Very High
agonist 2 99.10 Very High Very High Very High
nMDA receptor 5 96.96 Very High Very High Very High
Opioid 2 96.72 Very High Very High Very High
Action potential 2 95.16 Very High Very High Very High
tetrodotoxin 8 94.16 High High
Neuropeptide 9 93.44 High High
trigeminal ganglion 6 93.32 High High
Inflammation 16 91.20 High High
Disease Link Frequency Relevance Heat
Drug Induced Neurotoxicity 6 99.80 Very High Very High Very High
Ganglion Cysts 6 93.32 High High
Nociception 14 91.84 High High
INFLAMMATION 25 91.20 High High
Temporomandibular Joint Syndrome 13 86.24 High High
Recurrence 16 77.68 Quite High
Cognitive Disorder 2 9.12 Low Low
Aids-related Complex 22 5.00 Very Low Very Low Very Low
Cocaine Dependence 20 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another interesting finding from our study was that dietary GSE decreases basal expression of the MAP kinase-responsive gene CGRP, while increasing expression of GLAST in the TNC.
Gene_expression (expression) of MAP kinase-responsive gene associated with calcitonin gene-related peptide
1) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC3009976 Disease Relevance 0.97 Pain Relevance 0.93
Additional genes were included in the confirmation studies based on previous reports of cocaine-responsive gene expression (see Additional File 2: Table S2, for a full list and gene expression assay information).
Gene_expression (expression) of cocaine-responsive gene associated with cocaine
2) Confidence 0.01 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0 Pain Relevance 0.29
Many studies of cocaine-responsive gene expression have focused on changes occurring during cocaine exposure, but few studies have examined the persistence of these changes with cocaine abstinence.
Gene_expression (expression) of cocaine-responsive gene associated with cocaine
3) Confidence 0.01 Published 2010 Journal BMC Neurosci Section Abstract Doc Link PMC2837051 Disease Relevance 0.08 Pain Relevance 0.28
In this study, we investigated how the neuronal activity influence AhR-mediated dioxin-responsive gene expression and neurotoxicity.
Gene_expression (expression) of dioxin-responsive gene in neuronal associated with drug induced neurotoxicity
4) Confidence 0.00 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 17973980 Disease Relevance 0.17 Pain Relevance 0.44
Our results show that activation of AhR by the selective agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin induced dioxin-responsive gene expression and calcium entry, which were attenuated by AhR small interfering RNA, the NMDA receptor channel blocker MK801, and the action potential blocker tetrodotoxin (TTX).
Gene_expression (expression) of dioxin-responsive gene associated with tetrodotoxin, action potential, nmda receptor and agonist
5) Confidence 0.00 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 17973980 Disease Relevance 0.17 Pain Relevance 0.52

General Comments

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