INT147582
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
The risk of any event is reduced with AIs by 23%, with an absolute benefit of 3.8% (Bria et al 2006). | |||||||||||||||
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However, in this trial, as well as other postadjuvant or switching studies, it is difficult to deduce whether the cardiovascular adverse events observed may be attributed, at least in part, to the effects of prior tamoxifen or whether these events are a true effect of the AIs. | |||||||||||||||
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Therefore, the ratio of cord length/vertebral length was significantly reduced in severe AIS (ratio = 0.67) compared with the normal controls (ratio = 0.72). | |||||||||||||||
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Porter [28] stated that the putative impaired growth of the spinal cord in AIS may result from an abnormal response to stretch including: 1) inadequate cord growth from deficient hormonal environment; 2) cell membrane defect with abnormal function of contractile proteins in cells of the spinal cord as part of a systemic disorder; 3) abnormality of the elastin fibre system, 4) failure of melatonin to scavenge free radicals resulting in spinal cord stretch injury; and 5) hypoxia.
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Other criteria (greater number of AIS, greater AIS diameter, infratentorial location and gadolinium enhancement) should be used, in order to improve the specificity, only to the MRIs of elderly patients (> 50 years) with suspected MS or patients suspected of MS in whom alternative explanations seem equally similar. | |||||||||||||||
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Early discontinuation of AIs may result in an inadequate clinical response. | |||||||||||||||
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Of serious concern for prevention is the potential for increase in risk of bone fracture and cardiovascular disease related to long-term estrogen depletion with AIs. | |||||||||||||||
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Adverse events associated with tamoxifen include increased risk of uterine cancers and thromboembolic events vs. an increased incidence of vaginal dryness, loss of libido, musculoskeletal pain and bone mineral density loss with AIs. | |||||||||||||||
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It is hypothesized that when AIs decrease estrogen levels, light-induced melatonin suppression (LIMS) loses efficacy, leading to an abnormal melatonin cycle as seen in rheumatoid arthritis patients, producing (via mechanisms not yet understood) the symptoms of morning stiffness. | |||||||||||||||
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Class effects of AIs, favorable to AIs | |||||||||||||||
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Class effects of AIs, favorable to tamoxifen | |||||||||||||||
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Third-generation AIs, however, are potent inhibitors of oestrogen synthesis and have all been shown to significantly reduce the risk of thromboembolism compared with tamoxifen treatment in postmenopausal women with breast cancer. | |||||||||||||||
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In this group there was an 18% reduction in CIN 2/3 or AIS due to any HPV type. | |||||||||||||||
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Kv2.1 localization in a single proximal neurite with diminished MAP2 staining, i.e. the AIS (marked by the arrow in Fig. 3), was observed in 35% of 7 DIV neurons and 63% of 10 DIV neurons (200 neurons examined in each of three experiments). | |||||||||||||||
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A secondary aim was to observe whether the administration of vaccine reduced the combined incidence of CIN grades 13, AIS, or cervical cancer associated by vaccine type HPV. | |||||||||||||||
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General Comments
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