INT147582

Context Info Confidence 0.37 First Reported 1997 Last Reported 2010 Negated 0 Speculated 2 Reported most in Body Documents 13 Total Number 15 Disease Relevance 13.26 Pain Relevance 2.46

Anatomy Link Frequency neurons 1 spinal cord 1 uterine 1 AIS (Homo sapiens)

Pain Link Frequency Relevance Heat Spinal cord 186 100.00 cva 84 99.48 Pain 56 99.48 Multiple sclerosis 15 98.96 imagery 49 98.12 Dismenorea 13 97.36 agonist 16 97.28 rheumatoid arthritis 2 96.64 Analgesic 4 94.80 Nav1.2 1 82.52

Disease Link Frequency Relevance Heat Scoliosis 606 100.00 Cervical Intraepithelial Neoplasia 34 100.00 Cervical Cancer 81 99.80 Papillomavirus Infection 360 99.52 Cv General 3 Under Development 65 99.48 Pain 50 99.48 Cardiovascular Disease 29 99.38 Arthralgia 102 99.12 Reprotox - General 1 126 99.04 Demyelinating Disease 15 98.96

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The risk of any event is reduced with AIs by 23%, with an absolute benefit of 3.8% (Bria et al 2006).

Negative_regulation (reduced) of AIs

1) Confidence 0.37 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682397 Disease Relevance 0.40 Pain Relevance 0

However, in this trial, as well as other postadjuvant or switching studies, it is difficult to deduce whether the cardiovascular adverse events observed may be attributed, at least in part, to the effects of prior tamoxifen or whether these events are a true effect of the AIs.

Spec (whether) Negative_regulation (effect) of AIs

2) Confidence 0.37 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682397 Disease Relevance 0.67 Pain Relevance 0

Therefore, the ratio of cord length/vertebral length was significantly reduced in severe AIS (ratio = 0.67) compared with the normal controls (ratio = 0.72).

Negative_regulation (reduced) of AIS associated with scoliosis

3) Confidence 0.34 Published 2008 Journal Scoliosis Section Body Doc Link PMC2474583 Disease Relevance 0.99 Pain Relevance 0.25

Porter [28] stated that the putative impaired growth of the spinal cord in AIS may result from an abnormal response to stretch including: 1) inadequate cord growth from deficient hormonal environment; 2) cell membrane defect with abnormal function of contractile proteins in cells of the spinal cord as part of a systemic disorder; 3) abnormality of the elastin fibre system, 4) failure of melatonin to scavenge free radicals resulting in spinal cord stretch injury; and 5) hypoxia.

Negative_regulation (impaired) of AIS in spinal cord associated with scoliosis, hypoxia, injury and spinal cord

4) Confidence 0.33 Published 2008 Journal Scoliosis Section Body Doc Link PMC2474583 Disease Relevance 0.67 Pain Relevance 0.27

Other criteria (greater number of AIS, greater AIS diameter, infratentorial location and gadolinium enhancement) should be used, in order to improve the specificity, only to the MRIs of elderly patients (> 50 years) with suspected MS or patients suspected of MS in whom alternative explanations seem equally similar.

Negative_regulation (number) of AIS associated with multiple sclerosis

5) Confidence 0.30 Published 1997 Journal Srp Arh Celok Lek Section Abstract Doc Link 17974350 Disease Relevance 0.54 Pain Relevance 0.38

Early discontinuation of AIs may result in an inadequate clinical response.

Negative_regulation (discontinuation) of AIs

6) Confidence 0.27 Published 2010 Journal Clin J Oncol Nurs Section Abstract Doc Link 20529801 Disease Relevance 0.50 Pain Relevance 0.09

Of serious concern for prevention is the potential for increase in risk of bone fracture and cardiovascular disease related to long-term estrogen depletion with AIs.

Negative_regulation (depletion) of AIs associated with bone fracture and cardiovascular disease

7) Confidence 0.25 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC2228389 Disease Relevance 1.10 Pain Relevance 0.14

Adverse events associated with tamoxifen include increased risk of uterine cancers and thromboembolic events vs. an increased incidence of vaginal dryness, loss of libido, musculoskeletal pain and bone mineral density loss with AIs.

Negative_regulation (loss) of AIs in uterine associated with reprotox - general 2, pain, uterine cancer, cva and reprotox - general 1

8) Confidence 0.25 Published 2007 Journal International Journal of Clinical Practice Section Abstract Doc Link PMC2228389 Disease Relevance 0.73 Pain Relevance 0.15

It is hypothesized that when AIs decrease estrogen levels, light-induced melatonin suppression (LIMS) loses efficacy, leading to an abnormal melatonin cycle as seen in rheumatoid arthritis patients, producing (via mechanisms not yet understood) the symptoms of morning stiffness.

Negative_regulation (decrease) of AIs associated with rheumatoid arthritis

9) Confidence 0.21 Published 2008 Journal Med. Hypotheses Section Abstract Doc Link 18782656 Disease Relevance 0.62 Pain Relevance 0.37

Class effects of AIs, favorable to AIs

Negative_regulation (effects) of AIs

10) Confidence 0.15 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503653 Disease Relevance 0.52 Pain Relevance 0.05

Class effects of AIs, favorable to tamoxifen

Negative_regulation (effects) of AIs

11) Confidence 0.15 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503653 Disease Relevance 0.98 Pain Relevance 0.25

Third-generation AIs, however, are potent inhibitors of oestrogen synthesis and have all been shown to significantly reduce the risk of thromboembolism compared with tamoxifen treatment in postmenopausal women with breast cancer.

Negative_regulation (reduce) of AIs associated with breast cancer and cva

12) Confidence 0.15 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503653 Disease Relevance 1.30 Pain Relevance 0.39

In this group there was an 18% reduction in CIN 2/3 or AIS due to any HPV type.

Negative_regulation (reduction) of AIS associated with papillomavirus infection and cervical intraepithelial neoplasia

13) Confidence 0.05 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971720 Disease Relevance 2.03 Pain Relevance 0

Kv2.1 localization in a single proximal neurite with diminished MAP2 staining, i.e. the AIS (marked by the arrow in Fig. 3), was observed in 35% of 7 DIV neurons and 63% of 10 DIV neurons (200 neurons examined in each of three experiments).

Negative_regulation (diminished) of AIS in neurons

14) Confidence 0.04 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2592246 Disease Relevance 0 Pain Relevance 0.11

A secondary aim was to observe whether the administration of vaccine reduced the combined incidence of CIN grades 1–3, AIS, or cervical cancer associated by vaccine type HPV.

Spec (whether) Negative_regulation (reduced) of AIS associated with papillomavirus infection, cervical cancer and cervical intraepithelial neoplasia

15) Confidence 0.04 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971720 Disease Relevance 2.21 Pain Relevance 0

General Comments

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