INT147598

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.47
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CDKN2A) DNA binding (CDKN2A) protein complex (CDKN2A)
cytoplasm (CDKN2A) cytosol (CDKN2A) nucleolus (CDKN2A)
Anatomy Link Frequency
SCC-4 3
CAL-27 1
CDKN2A (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 2 97.64 Very High Very High Very High
COX-2 inhibitor 52 93.20 High High
Opioid 4 75.00 Quite High
Enkephalin 2 60.96 Quite High
cINOD 17 57.32 Quite High
aspirin 4 47.00 Quite Low
Inflammation 26 5.00 Very Low Very Low Very Low
cytokine 11 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloid Leukemia 1 91.64 High High
Leukemia 9 91.44 High High
Cancer 126 86.84 High High
Death 27 84.24 Quite High
Apoptosis 151 83.36 Quite High
Retinoblastoma 4 82.28 Quite High
Pancreatic Cancer 1 80.36 Quite High
Head & Neck Cancer 4 75.00 Quite High
Lymphatic System Cancer 4 72.84 Quite High
Breast Cancer 5 65.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of p16 (INK4a) activation by p16-specific siRNA blocked OGF's repressive action on proliferation of SCC-1, CAL-27, and SCC-4 HNSCC cells.
Negative_regulation (Inhibition) of Positive_regulation (activation) of p16 in SCC-4
1) Confidence 0.41 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17974995 Disease Relevance 0.21 Pain Relevance 0.24
Inhibition of p16 (INK4a) activation by p16-specific siRNA blocked OGF's repressive action on proliferation of SCC-1, CAL-27, and SCC-4 HNSCC cells.
Negative_regulation (Inhibition) of in CAL-27 Positive_regulation (activation) of p16 in SCC-4
2) Confidence 0.14 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17974995 Disease Relevance 0.21 Pain Relevance 0.24
Moreover, the inhibition of cell proliferation was correlated to a downregulation of cyclin D1, cyclin E, and pRb and the upregulation of p16 and p27 [89].
Negative_regulation (downregulation) of Positive_regulation (upregulation) of p16
3) Confidence 0.09 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.05 Pain Relevance 0.10

General Comments

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