INT147602

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Context Info
Confidence 0.35
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.60
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDK4) nucleoplasm (CDK4) signal transduction (CDK4)
nucleolus (CDK4) nucleus (CDK4) cell cycle (CDK4)
CDK4 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 130 98.50 Very High Very High Very High
Taxol 2 80.76 Quite High
Enkephalin 1 77.00 Quite High
Opioid 2 75.40 Quite High
narcan 1 74.24 Quite High
Kinase C 1 58.72 Quite High
COX-2 inhibitor 52 45.64 Quite Low
withdrawal 5 45.56 Quite Low
Inflammation 29 44.32 Quite Low
Pain 3 43.64 Quite Low
Disease Link Frequency Relevance Heat
Retinoblastoma 4 98.84 Very High Very High Very High
Breast Cancer 75 97.92 Very High Very High Very High
Hypoxia 37 96.64 Very High Very High Very High
Apoptosis 240 95.60 Very High Very High Very High
Cancer 260 93.16 High High
Congenital Anomalies 2 87.20 High High
Reprotox - General 1 4 83.16 Quite High
Squamous Cell Carcinoma 1 82.12 Quite High
Pancreatic Cancer 16 81.56 Quite High
Head & Neck Cancer 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This change was correlated with reduced Cdk4, but not Cdk2, kinase activity.
Negative_regulation (reduced) of Cdk4
1) Confidence 0.35 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17974995 Disease Relevance 0.24 Pain Relevance 0.26
In our experiments, CDK2 and CDK4 protein levels decreased with ALA treatment preventing cells proliferation.
Negative_regulation (decreased) of CDK4
2) Confidence 0.33 Published 2002 Journal BMC Cancer Section Body Doc Link PMC101407 Disease Relevance 0.60 Pain Relevance 0
CDK2 and CDK4 protein levels were reduced after ALA treatment at physiological concentrations.



Negative_regulation (reduced) of CDK4
3) Confidence 0.33 Published 2002 Journal BMC Cancer Section Abstract Doc Link PMC101407 Disease Relevance 0.47 Pain Relevance 0
This was associated with downregulation of the levels of cyclins D1 and B1, and with inhibition of CDK1, CDK2 and CDK4.
Negative_regulation (inhibition) of CDK4
4) Confidence 0.31 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.63 Pain Relevance 0.07
The inhibition of cyclin D1-CDK4/6 complex activity prevents retinoblastoma protein phosphorylation and release of E2F, leading to the inhibition of cell cycle in G1/S transition [3].
Negative_regulation (inhibition) of CDK4 associated with retinoblastoma
5) Confidence 0.30 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1185532 Disease Relevance 0.86 Pain Relevance 0
Capsaicin-induced G1 arrest is correlated with the suppression of cyclin D1 levels, inhibition of cdk4 activity and Rb phosphorylation in endothelial and breast cancer cells [21], [22].
Negative_regulation (inhibition) of cdk4 associated with qutenza and breast cancer
6) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 1.06 Pain Relevance 0.71
INK4 family inhibits Cdk4 and Cdk6, whereas Cip/Kip family inhibits all Cdks.
Negative_regulation (inhibits) of Cdk4
7) Confidence 0.18 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 0.29 Pain Relevance 0
The attenuation of cell proliferation by Rex1 inhibition was attended by the downregulation of CDK2, CDK4, and Cyclin 2 (Figure 3C).
Negative_regulation (downregulation) of CDK4
8) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.45 Pain Relevance 0

General Comments

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