INT147606

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.35
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR1) plasma membrane (TLR1) intracellular (TLR1)
Anatomy Link Frequency
monocytes 1
T cells 1
TLR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 47 99.08 Very High Very High Very High
Pain 3 98.44 Very High Very High Very High
pruritus 3 98.08 Very High Very High Very High
agonist 8 88.24 High High
Inflammation 56 72.96 Quite High
chemokine 17 59.12 Quite High
antagonist 5 47.28 Quite Low
Paracetamol 2 31.52 Quite Low
psoriasis 19 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 106 98.88 Very High Very High Very High
Pain 3 98.44 Very High Very High Very High
Pruritus 3 98.08 Very High Very High Very High
Disease 32 97.80 Very High Very High Very High
Infection 10 96.72 Very High Very High Very High
Herpes Simplex Virus 1 95.60 Very High Very High Very High
Necrosis 4 92.80 High High
Dermatitis 28 92.24 High High
Sprains And Strains 40 91.32 High High
Bacterial Infection 3 90.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Manipulation of immunocompetent cells through stimulation of Toll-like receptors (TLR) seems to be of particular interest [108, 109].
Positive_regulation (stimulation) of TLR
1) Confidence 0.67 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896720 Disease Relevance 0.21 Pain Relevance 0.04
Stimulation of TLR1/2 (which recognize triacylated lipopeptides) in monocytes from older adults yielded a blunted production of TNF-?
Positive_regulation (Stimulation) of TLR1 in monocytes
2) Confidence 0.31 Published 2009 Journal The Yale Journal of Biology and Medicine Section Body Doc Link PMC2794489 Disease Relevance 0.48 Pain Relevance 0.14
Induction of TIL manifested clinically with tumor site pain and pruritus and pathologically with alterations in the tumor microenvironment, featuring histiocytic accumulation and widespread tumor necrosis. hTERT-specific CD8+ T cells were also evident after vaccination in the peripheral blood of patients and exhibited effector functions in vitro including proliferation, IFN-gamma production, and tumor lysis.
Positive_regulation (Induction) of TIL in T cells associated with pain, necrosis, cancer and pruritus
3) Confidence 0.30 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17974999 Disease Relevance 1.36 Pain Relevance 0.15
In some cases, MyD88 acts in concert with other adaptors, such as MAL/TIRAP, in the response triggered by stimulating TLR4, TLR1/2, and TLR2/6.
Positive_regulation (stimulating) of TLR1
4) Confidence 0.21 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 0 Pain Relevance 0
These pathogens express microbial products that stimulate TLR 1, 2, 6, and 9.
Positive_regulation (stimulate) of TLR 1
5) Confidence 0.05 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 2.30 Pain Relevance 0.14

General Comments

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