INT147607

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 12.36
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TERT) DNA binding (TERT) cytoplasm (TERT)
RNA binding (TERT) chromosome (TERT) nucleolus (TERT)
Anatomy Link Frequency
telomere 2
poly 1
liver 1
nodules 1
cytotoxic T cells 1
TERT (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 54 99.98 Very High Very High Very High
fibrosis 79 99.16 Very High Very High Very High
Inflammation 9 98.90 Very High Very High Very High
transdermal 46 93.24 High High
Pain 15 85.36 High High
cytokine 16 70.28 Quite High
ischemia 15 65.60 Quite High
pruritus 4 45.60 Quite Low
agonist 4 35.80 Quite Low
Kinase C 47 31.84 Quite Low
Disease Link Frequency Relevance Heat
Compartment Syndromes 92 100.00 Very High Very High Very High
Cancer 40 100.00 Very High Very High Very High
Depression 66 99.98 Very High Very High Very High
Disease 59 99.98 Very High Very High Very High
Congenital Anomalies 3 99.98 Very High Very High Very High
Hypogonadotropic Hypogonadism 143 99.96 Very High Very High Very High
Reprotox - General 1 100 99.78 Very High Very High Very High
Peliosis Hepatis 3 99.64 Very High Very High Very High
Prolactinoma 3 99.44 Very High Very High Very High
Aging 230 99.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, some health workers at district level associate the responsibility of TCs not only with the hospital where they are deployed but for a larger geographical area:

"...

TCs Binding (associate) of
1) Confidence 0.48 Published 2007 Journal Hum Resour Health Section Body Doc Link PMC2235883 Disease Relevance 0.09 Pain Relevance 0
The coexistence of inflammation and fibrosis may be a characteristic of organ disease associated with telomerase mutations.
telomerase Binding (associated) of associated with fibrosis, inflammation and disease
2) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873288 Disease Relevance 1.88 Pain Relevance 0.52
The human telomerase reverse transcriptase (hTERT) is nearly universally overexpressed in human cancer, contributes critically to oncogenesis, and is recognized by cytotoxic T cells that lyse tumors.
telomerase reverse transcriptase Binding (recognized) of in cytotoxic T cells associated with cancer
3) Confidence 0.33 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17974999 Disease Relevance 0.66 Pain Relevance 0
A small group of professionals, mainly specialists, raised concerns regarding practice regulation; they considered that in some instances TCs intervene above their abilities:

"There should be a regulation regarding the interventions that the TCs can perform; some perform surgery above their capacities, for example: fistulas, prostate cancer, etc.

TCs Binding (intervene) of associated with fistula and reprotox - general 1
4) Confidence 0.32 Published 2007 Journal Hum Resour Health Section Body Doc Link PMC2235883 Disease Relevance 0.19 Pain Relevance 0
Interviewees, mainly non-physician staff, mostly associate the TCs' importance with the key role they play in maternal care and life saving skills in general.
TCs Binding (associate) of
5) Confidence 0.32 Published 2007 Journal Hum Resour Health Section Body Doc Link PMC2235883 Disease Relevance 0 Pain Relevance 0
The majority of them referred to a variety of difficulties in collaborating with TCs.
TCs Binding (collaborating) of
6) Confidence 0.32 Published 2007 Journal Hum Resour Health Section Body Doc Link PMC2235883 Disease Relevance 0.16 Pain Relevance 0
In aging men with late-onset hypogonadism, TRT may normalize serum androgen levels but appears to have little effect on prostate tissue androgen levels and cellular functions266 and causes no significant adverse affects on the prostate.267 At the present time, there is no conclusive evidence that testosterone therapy increases the risk of prostate cancer or benign prostatic hyperplasia (BPH).45,268,269
TRT Neg (no) Binding (normalize) of associated with benign prostatic hypertrophy, aging, hypogonadotropic hypogonadism and reprotox - general 1
7) Confidence 0.25 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2701485 Disease Relevance 1.47 Pain Relevance 0
The presence of breast cancer is also a contraindication for TRT as well as a prolactinoma, as their growth may be stimulated by HRT.26 Very high risk of serious adverse outcomes, undiagnosed prostate nodules or indurations, unexplained PSA elevation, erythrocytosis (hematocrit > 50%), severe lower urinary tract symptoms with benign prostatic hyperplasia with an International Prostate Symptom Score (IPSS) >19, and unstable congestive heart failure (class III or IV), untreated obstructive sleep apnea are considered as moderate- to high-risk factors for potential adverse outcomes.26,45,319

Conclusion

TRT Binding (contraindication) of in nodules associated with apnoea, benign prostatic hypertrophy, erythrocytosis, prolactinoma, frailty, lower urinary tract symptoms and reprotox - general 1
8) Confidence 0.25 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2701485 Disease Relevance 1.14 Pain Relevance 0
Other liver abnormalities associated with TRT include Peliosis hepatis, hepatocellular adenoma, and carcinoma.299

The risk of polycythemia

TRT Binding (associated) of in liver associated with peliosis hepatis, erythrocytosis, congenital anomalies, carcinoma and liver cell adenoma
9) Confidence 0.24 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2701485 Disease Relevance 1.15 Pain Relevance 0.05
There was positive immunoreactivity for TERT and pAkt in all treatment groups, but a subjective decrease in staining was observed in the 7.5 ?
TERT Binding (immunoreactivity) of
10) Confidence 0.16 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994344 Disease Relevance 0.13 Pain Relevance 0
That there is an association between depression and testosterone concentration seems possible because of the observation that depression may be associated with reduced testosterone concentrations, hypogonadal men may have their symptoms of depression relieved by TRT and that testosterone itself may have anti-depressant properties (Pope et al 2003).
TRT Binding (relieved) of associated with depression
11) Confidence 0.16 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2686330 Disease Relevance 1.33 Pain Relevance 0.46
specific binding site on hTERT promoter remains to be explored.
hTERT Binding (binding) of
12) Confidence 0.15 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.14 Pain Relevance 0
The difficulty in managing patients who are at risk for developing TCS is early recognition, especially in the poly-trauma patient who is intubated and sedated.
TCS Binding (recognition) of in poly associated with compartment syndromes and injury
13) Confidence 0.06 Published 2010 Journal Patient Saf Surg Section Body Doc Link PMC2933643 Disease Relevance 1.26 Pain Relevance 0.09
TCS is often associated with high energy trauma and is difficult to diagnose in uncooperative, obtunded and multiply injured patients.
TCS Binding (associated) of associated with compartment syndromes and injury
14) Confidence 0.06 Published 2010 Journal Patient Saf Surg Section Abstract Doc Link PMC2933643 Disease Relevance 1.52 Pain Relevance 0.06
To counteract telomere shortening, cells can express the enzyme telomerase (hTERT), which synthesizes new telomeric repeats, thereby maintaining or increasing telomere length.
hTERT Binding (maintaining) of in telomere
15) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206356 Disease Relevance 0.62 Pain Relevance 0.06
To counteract telomere shortening, cells can express the enzyme telomerase (hTERT), which synthesizes new telomeric repeats, thereby maintaining or increasing telomere length.
enzyme telomerase Binding (maintaining) of in telomere
16) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206356 Disease Relevance 0.62 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox