INT147619

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Npr1, Calca) extracellular space (Calca) aging (Calca)
extracellular region (Calca) nucleus (Calca) plasma membrane (Npr1)
Npr1 (Rattus norvegicus)
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 1 100.00 Very High Very High Very High
nociceptor 6 84.08 Quite High
Calcitonin gene-related peptide 4 79.36 Quite High
c fibre 1 78.00 Quite High
Action potential 1 76.76 Quite High
Neuropeptide 1 66.12 Quite High
neuropeptide release 1 62.72 Quite High
bradykinin 1 50.60 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The adenylyl cyclase activator forskolin and the protein kinase C activator phorbol ester (PMA, 10 microM for both) facilitated heat-induced iCGRP release whereas increasing the intracellular Ca(2+) concentration by 10 microM ionomycin produced a desensitization of the response.
cyclase Positive_regulation (facilitated) of Localization (release) of iCGRP associated with kinase c
1) Confidence 0.03 Published 2007 Journal Life Sci. Section Abstract Doc Link 17976660 Disease Relevance 0 Pain Relevance 0.75

General Comments

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