INT147634

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Context Info
Confidence 0.44
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.23
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd28)
Anatomy Link Frequency
T-cell 2
Cd28 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
abatacept 15 99.74 Very High Very High Very High
rheumatoid arthritis 72 99.36 Very High Very High Very High
methotrexate 3 94.04 High High
cytokine 8 46.08 Quite Low
antagonist 6 14.84 Low Low
Infliximab 6 12.80 Low Low
Adalimumab 6 11.60 Low Low
Inflammation 4 5.00 Very Low Very Low Very Low
Etanercept 4 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 72 99.36 Very High Very High Very High
Alagille Syndrome 64 98.76 Very High Very High Very High
Cytomegalovirus Infection 174 98.60 Very High Very High Very High
Autoimmune Disease 2 73.76 Quite High
Polycystic Ovary Syndrome 4 68.40 Quite High
Infection 40 58.88 Quite High
Disease 17 52.80 Quite High
Necrosis 6 50.00 Quite Low
Cancer 6 50.00 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 48.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Abatacept selectively modulates the CD80/CD86:CD28 co-stimulatory signal required for full T-cell activation, and has been approved for the treatment of rheumatoid arthritis (RA) in combination with methotrexate in a number of countries, including the United States, Canada, and the European Union.
Regulation (modulates) of CD28 in T-cell associated with rheumatoid arthritis, abatacept and methotrexate
1) Confidence 0.44 Published 2007 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 17977488 Disease Relevance 0.38 Pain Relevance 0.52
We followed the proportion of CD28neg CD4pos T cells during the course of anti-TNF treatment.
Regulation (proportion) of CD28neg in T cells
2) Confidence 0.10 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945035 Disease Relevance 1.16 Pain Relevance 0.25
It has been reported that the CD28neg population is enriched in RA patients [29] and that this phenotype is due to TNF-?
Regulation (population) of CD28neg associated with rheumatoid arthritis
3) Confidence 0.10 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945035 Disease Relevance 1.69 Pain Relevance 0.05

General Comments

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