INT14764

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Context Info
Confidence 0.59
First Reported 1987
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 28
Total Number 29
Disease Relevance 11.29
Pain Relevance 12.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Nppa) nucleus (Nppa) cytoplasm (Nppa)
Anatomy Link Frequency
plasma 6
myocytes 2
blood 2
tubule 2
right atrium 2
Nppa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 20 99.96 Very High Very High Very High
Morphine 6 99.84 Very High Very High Very High
Dynorphin 30 99.82 Very High Very High Very High
Clonidine 29 99.76 Very High Very High Very High
Opioid 11 99.72 Very High Very High Very High
tetrodotoxin 10 99.52 Very High Very High Very High
Somatostatin 42 99.36 Very High Very High Very High
antagonist 20 98.96 Very High Very High Very High
anesthesia 6 98.90 Very High Very High Very High
qutenza 5 96.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Natriuresis 58 100.00 Very High Very High Very High
Heart Rate Under Development 20 99.58 Very High Very High Very High
Aging 3 99.52 Very High Very High Very High
Schizophrenia 6 99.40 Very High Very High Very High
Overactive Bladder 52 97.84 Very High Very High Very High
Hypertension 31 97.84 Very High Very High Very High
Abnormal Reflex 1 93.76 High High
Hyponatremia 19 93.00 High High
Neurological Disease 1 91.84 High High
Urethral Stricture 1 90.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A decrease of blood pressure and heart rate and a suppression of ANF release elicited by clonidine were significantly greater in SHRsp than in WKY rats.
Negative_regulation (suppression) of Localization (release) of ANF in blood associated with clonidine
1) Confidence 0.59 Published 1991 Journal Sheng Li Xue Bao Section Abstract Doc Link 1836674 Disease Relevance 0.58 Pain Relevance 0.60
Substantial ANP secretion persisted in a nominally Ca2+-free medium containing 10 mM ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGTA) and was not diminished by 100 microM ryanodine.
Negative_regulation (persisted) of Localization (secretion) of ANP
2) Confidence 0.59 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2466408 Disease Relevance 0.16 Pain Relevance 0.19
Clonidine-stimulated ANF secretion was partially inhibited by yohimbine from 457.1 +/- 66.3 pg/ml (mean +/- S.E.M.) to 99.9 +/- 23.1 pg/ml.
Negative_regulation (inhibited) of Localization (secretion) of ANF associated with clonidine
3) Confidence 0.59 Published 1987 Journal Neurosci. Lett. Section Abstract Doc Link 3035429 Disease Relevance 0.15 Pain Relevance 0.54
This treatment inhibited ANF released through in vivo blood volume expansion and through balloon inflation in the right atrium of in vitro isolated perfused hearts.
Negative_regulation (inhibited) of Localization (released) of ANF in right atrium
4) Confidence 0.59 Published 1990 Journal Regul. Pept. Section Abstract Doc Link 1703316 Disease Relevance 0.16 Pain Relevance 0.39
Somatostatin (1 pM to 1 microM) caused a concentration-dependent decrease in ANP secretion (EC(50), 0.7 nM) that was abolished by addition of the somatostatin subtype 2 receptor (sst2) antagonist, PRL2903.
Negative_regulation (decrease) of Localization (secretion) of ANP associated with antagonist and somatostatin
5) Confidence 0.55 Published 2003 Journal Regul. Pept. Section Abstract Doc Link 12527142 Disease Relevance 0.14 Pain Relevance 0.76
The dynorphin-induced ANP secretion, as well as the basal secretion, were significantly decreased by the addition of 3-isobutyl-1-methylxanthine, a phosphodiesterase inhibitor, as compared with the respective controls.
Negative_regulation (decreased) of Localization (secretion) of ANP associated with dynorphin
6) Confidence 0.54 Published 1991 Journal Am. J. Physiol. Section Abstract Doc Link 1716056 Disease Relevance 0.13 Pain Relevance 0.96
Inhibition of atrial natriuretic peptide secretion by forskolin in noncontracting cultured atrial myocytes.
Negative_regulation (Inhibition) of Localization (secretion) of atrial natriuretic peptide in myocytes associated with natriuresis
7) Confidence 0.47 Published 1988 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 2461711 Disease Relevance 0.20 Pain Relevance 0.13
It is suggested that the biosynthesis and storage of ANF in atria be increased and its release from atria decreased in morphine tolerant rats.
Negative_regulation (decreased) of Localization (release) of ANF associated with morphine
8) Confidence 0.43 Published 1989 Journal Sheng Li Xue Bao Section Abstract Doc Link 2533995 Disease Relevance 0.07 Pain Relevance 0.40
Substantial ANP secretion persisted in a nominally Ca2+-free medium containing 10 mM ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGTA) and was not diminished by 100 microM ryanodine.
Neg (not) Negative_regulation (diminished) of Localization (secretion) of ANP
9) Confidence 0.43 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2466408 Disease Relevance 0.16 Pain Relevance 0.19
Propranolol and tetrodotoxin significantly (p<0.01) inhibited 55% and 60%, respectively, the toxin-induced ANP release.
Negative_regulation (inhibited) of Localization (release) of ANP associated with tetrodotoxin
10) Confidence 0.43 Published 2008 Journal Peptides Section Abstract Doc Link 18191303 Disease Relevance 0.13 Pain Relevance 0.27
From these results, it would appear that a) isotonic saline alone does not stimulate IR-ANF release when used to expand blood volume, and b) barbiturate anesthesia significantly lowers resting plasma IR-ANF levels and attenuates the release of IR-ANF in response to volume expansion.
Negative_regulation (attenuates) of Localization (release) of IR-ANF in plasma associated with anesthesia
11) Confidence 0.43 Published 1990 Journal J Pharmacol Methods Section Abstract Doc Link 2139484 Disease Relevance 0 Pain Relevance 0.10
ANP release stimulated by moxonidine (10(-6) M) was inhibited by co-perfusion with the antagonists, AGN192403 (imidazoline I1-receptor), phenoxybenzamine (alpha2>alpha1-adrenoceptors), and prazosin (alpha1>alpha2-adrenoceptors), but increased by rauwolscine (alpha2-adrenoceptors).
Negative_regulation (inhibited) of Localization (release) of ANP associated with antagonist
12) Confidence 0.43 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16774751 Disease Relevance 0.20 Pain Relevance 0.18
Perfusion with 10(-5) M brimonidine (full alpha2-adrenoceptor agonist) inhibited moxonidine-stimulated ANP release.
Negative_regulation (inhibited) of Localization (release) of ANP associated with agonist
13) Confidence 0.43 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16774751 Disease Relevance 0.22 Pain Relevance 0.29
In contrast, a beta-AR agonist, isoproterenol decreased ANP release with positive inotropism and these responses were blocked by the beta(1)-AR antagonist but not by the beta(2)-AR antagonist.
Negative_regulation (decreased) of Localization (release) of ANP associated with antagonist and agonist
14) Confidence 0.43 Published 2008 Journal Peptides Section Abstract Doc Link 18378355 Disease Relevance 0.57 Pain Relevance 0.64
The present data suggest that the significantly reduced (about -20%) natriuretic and kaliuretic responses of the aged rat, observed 20 min after the onset of hypertonic volume expansion, could be partly due to a primary defect in cardiac production and/or release of ANF rather than to a reduction of renal responsivity to ANF.
Negative_regulation (defect) of Localization (release) of ANF associated with natriuresis
15) Confidence 0.43 Published 1996 Journal Gerontology Section Abstract Doc Link 9138977 Disease Relevance 0.53 Pain Relevance 0.15
The diuretic effect of clonidine appears to be related to ANF release but not to inhibition of vasopressin.
Negative_regulation (inhibition) of Localization (release) of ANF associated with clonidine
16) Confidence 0.43 Published 1988 Journal Peptides Section Abstract Doc Link 2856643 Disease Relevance 0.24 Pain Relevance 0.68
In patients with severe CHF opioid peptides may attenuate ANF secretion reducing noradrenergic stimulation.
Negative_regulation (reducing) of Localization (secretion) of ANF associated with heart rate under development and opioid
17) Confidence 0.42 Published 1993 Journal Eur. Heart J. Section Abstract Doc Link 8095454 Disease Relevance 0.70 Pain Relevance 0.90
In patients with severe CHF opioid peptides may attenuate ANF secretion reducing noradrenergic stimulation.
Spec (may) Negative_regulation (attenuate) of Localization (secretion) of ANF associated with heart rate under development and opioid
18) Confidence 0.42 Published 1993 Journal Eur. Heart J. Section Abstract Doc Link 8095454 Disease Relevance 0.71 Pain Relevance 0.90
Therefore, we tested the hypothesis that endogenous release of atrial natriuretic factor (ANF) may downregulate alveolar epithelial Na+ and fluid transport in the presence of LA hypertension.
Negative_regulation (downregulate) of Localization (release) of atrial natriuretic factor associated with natriuresis and hypertension
19) Confidence 0.41 Published 1999 Journal J. Appl. Physiol. Section Abstract Doc Link 9887124 Disease Relevance 1.07 Pain Relevance 0.19
Therefore, we tested the hypothesis that endogenous release of atrial natriuretic factor (ANF) may downregulate alveolar epithelial Na+ and fluid transport in the presence of LA hypertension.
Negative_regulation (downregulate) of Localization (release) of ANF associated with natriuresis and hypertension
20) Confidence 0.41 Published 1999 Journal J. Appl. Physiol. Section Abstract Doc Link 9887124 Disease Relevance 1.07 Pain Relevance 0.19

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