INT147659

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.42
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkce, TRPV1) plasma membrane (Prkce, TRPV1) transport (TRPV1)
mitochondrion (Prkce) endoplasmic reticulum (Prkce) enzyme binding (Prkce)
Anatomy Link Frequency
neurons 1
primary sensory neurons 1
Prkce (Mus musculus)
TRPV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hyperalgesia 10 99.90 Very High Very High Very High
Neuropeptide 2 98.20 Very High Very High Very High
substance P 20 97.68 Very High Very High Very High
unmyelinated 2 96.36 Very High Very High Very High
Pain 4 93.64 High High
Neurotransmitter 2 93.40 High High
dorsal root ganglion 8 91.88 High High
Dorsal horn neuron 2 86.40 High High
qutenza 6 75.24 Quite High
Inflammation 2 71.84 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 10 99.90 Very High Very High Very High
Pain 6 93.64 High High
Ganglion Cysts 8 91.88 High High
INFLAMMATION 2 71.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCepsilon: a novel pathway for heat hyperalgesia.
PKCepsilon Positive_regulation (enhances) of TRPV1 in primary sensory neurons associated with hyperalgesia
1) Confidence 0.04 Published 2007 Journal J. Neurosci. Section Title Doc Link 17978048 Disease Relevance 0.74 Pain Relevance 1.33
Activation of NK-1 in these neurons induces heat hyperalgesia via PKCepsilon-mediated potentiation of TRPV1.
PKCepsilon Positive_regulation (potentiation) of TRPV1 in neurons associated with hyperalgesia
2) Confidence 0.04 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17978048 Disease Relevance 0.68 Pain Relevance 1.10

General Comments

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