INT147660

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.69
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkce, TRPV1) plasma membrane (Prkce, TRPV1) transport (TRPV1)
mitochondrion (Prkce) endoplasmic reticulum (Prkce) enzyme binding (Prkce)
Anatomy Link Frequency
neurons 2
Prkce (Mus musculus)
TRPV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hyperalgesia 5 100.00 Very High Very High Very High
substance P 10 98.48 Very High Very High Very High
dorsal root ganglion 4 93.08 High High
Inflammation 1 73.04 Quite High
Spontaneous pain 1 70.92 Quite High
qutenza 3 69.92 Quite High
antagonist 2 68.92 Quite High
agonist 1 57.28 Quite High
Dorsal horn neuron 1 40.88 Quite Low
Pain 2 35.72 Quite Low
Disease Link Frequency Relevance Heat
Hyperalgesia 5 100.00 Very High Very High Very High
Ganglion Cysts 4 93.08 High High
INFLAMMATION 1 73.04 Quite High
Pain 3 70.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of NK-1 in these neurons induces heat hyperalgesia via PKCepsilon-mediated potentiation of TRPV1.
Positive_regulation (induces) of PKCepsilon Positive_regulation (potentiation) of TRPV1 in neurons associated with hyperalgesia
1) Confidence 0.04 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17978048 Disease Relevance 0.69 Pain Relevance 1.12

General Comments

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