INT147663

Context Info Confidence 0.33 First Reported 2007 Last Reported 2010 Negated 0 Speculated 2 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.99 Pain Relevance 0.07

nucleus (Atf2) intracellular (Atf2) DNA binding (Atf2)

Anatomy Link Frequency macrophages 2 SCN 2 Atf2 (Mus musculus)

Pain Link Frequency Relevance Heat tetrodotoxin 1 74.96 addiction 2 5.00 cytokine 2 5.00 lidocaine 1 5.00 withdrawal 1 5.00 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Infection 66 97.28 Mycobacterial Infection 141 87.36 Apoptosis 129 61.68 Death 11 5.00 Sprains And Strains 5 5.00 Neutrophil Disorders 3 5.00 Targeted Disruption 3 5.00 Ulcers 2 5.00 Hypoxia 2 5.00 Suicidal Behaviour 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Here, we tested the putative role of GRP as an intra-SCN light signal at the behavioral and cellular levels, and we also tested whether GRP actions are dependent on activation of the cAMP response element-binding protein (CREB) pathway and Per1.

Spec (whether) Positive_regulation (dependent) of Spec (whether) Positive_regulation (activation) of cAMP response element-binding protein in SCN

1) Confidence 0.33 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17978049 Disease Relevance 0 Pain Relevance 0.07

secretion by macrophages needs to be investigated in more detail but activation of transcription factors such as ATF-2, Elk-1 and c-Jun upon JNK activation have been reported and would lead to an increase in TNF-?

Spec (investigated) Positive_regulation (investigated) of Spec (investigated) Positive_regulation (activation) of ATF-2 in macrophages

2) Confidence 0.04 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858756 Disease Relevance 0.99 Pain Relevance 0

General Comments

This test has worked.