INT147663

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Context Info
Confidence 0.33
First Reported 2007
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.99
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Atf2) intracellular (Atf2) DNA binding (Atf2)
Anatomy Link Frequency
macrophages 2
SCN 2
Atf2 (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 1 74.96 Quite High
addiction 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
lidocaine 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 66 97.28 Very High Very High Very High
Mycobacterial Infection 141 87.36 High High
Apoptosis 129 61.68 Quite High
Death 11 5.00 Very Low Very Low Very Low
Sprains And Strains 5 5.00 Very Low Very Low Very Low
Neutrophil Disorders 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Ulcers 2 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low
Suicidal Behaviour 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we tested the putative role of GRP as an intra-SCN light signal at the behavioral and cellular levels, and we also tested whether GRP actions are dependent on activation of the cAMP response element-binding protein (CREB) pathway and Per1.
Spec (whether) Positive_regulation (dependent) of Spec (whether) Positive_regulation (activation) of cAMP response element-binding protein in SCN
1) Confidence 0.33 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17978049 Disease Relevance 0 Pain Relevance 0.07
secretion by macrophages needs to be investigated in more detail but activation of transcription factors such as ATF-2, Elk-1 and c-Jun upon JNK activation have been reported and would lead to an increase in TNF-?
Spec (investigated) Positive_regulation (investigated) of Spec (investigated) Positive_regulation (activation) of ATF-2 in macrophages
2) Confidence 0.04 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2858756 Disease Relevance 0.99 Pain Relevance 0

General Comments

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