INT14768

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Context Info
Confidence 0.56
First Reported 1984
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 5.51
Pain Relevance 13.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Insr) endosome (Insr) plasma membrane (Insr)
nucleus (Insr)
Anatomy Link Frequency
neurons 10
MPO 6
MnPO 4
lateral 4
spinal 2
Insr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 50 100.00 Very High Very High Very High
Eae 22 100.00 Very High Very High Very High
Somatostatin 21 100.00 Very High Very High Very High
Dorsal horn 17 100.00 Very High Very High Very High
spinal dorsal horn 3 99.68 Very High Very High Very High
amygdala 18 99.44 Very High Very High Very High
Inflammation 8 99.44 Very High Very High Very High
antagonist 12 99.20 Very High Very High Very High
vagus nerve 6 99.12 Very High Very High Very High
dorsal root ganglion 5 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 12 100.00 Very High Very High Very High
Ganglion Cysts 10 99.88 Very High Very High Very High
INFLAMMATION 5 99.44 Very High Very High Very High
Urological Neuroanatomy 18 98.92 Very High Very High Very High
Pain 11 98.30 Very High Very High Very High
Hyperalgesia 4 98.16 Very High Very High Very High
Hemorrhage 2 89.36 High High
Stress 2 82.00 Quite High
Pressure Volume 2 Under Development 1 80.16 Quite High
Hemorrhagic Shock 2 80.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with morphine (3 and 10 mg/kg, i.p.) significantly reduced the induction of Fos-IR neurons at the superficial layers of the ipsilateral SpVc in a dose-dependent manner, and its effect was antagonized by the subsequent treatment of naloxone (2 mg/kg, i.p.).
Negative_regulation (reduced) of Positive_regulation (induction) of Fos-IR in neurons associated with narcan and morphine
1) Confidence 0.56 Published 1999 Journal Brain Res. Section Abstract Doc Link 10082860 Disease Relevance 0.05 Pain Relevance 0.43
The present results indicate that the induction of Fos-IR neurons in the dorsal horn caused by CCI is biphasic and reaches its maximal level on PO 3d, near the time of hyperalgesia onset.
Negative_regulation (reaches) of Positive_regulation (induction) of Fos-IR in neurons associated with hyperalgesia, eae and dorsal horn
2) Confidence 0.42 Published 2001 Journal Brain Res. Section Abstract Doc Link 11578603 Disease Relevance 0.54 Pain Relevance 0.88
The present results indicate that the induction of Fos-IR neurons in the dorsal horn caused by CCI is biphasic and reaches its maximal level on PO 3d, near the time of hyperalgesia onset.
Negative_regulation (reaches) of Positive_regulation (induction) of Fos-IR in neurons associated with hyperalgesia, eae and dorsal horn
3) Confidence 0.42 Published 2001 Journal Brain Res. Section Abstract Doc Link 11578603 Disease Relevance 0.54 Pain Relevance 0.88
Administrations of morphine (3 and 10 mg/kg, i.p.) drastically reduced the induction of Fos-IR neurons in all subnuclei of both the ipsilateral and contralateral PBN in a dose-dependent manner, and its effect was antagonized by pretreatment with naloxone (2 mg/kg, i.p.).
Negative_regulation (reduced) of Positive_regulation (induction) of Fos-IR in neurons associated with narcan and morphine
4) Confidence 0.41 Published 2001 Journal Brain Res. Section Abstract Doc Link 11454327 Disease Relevance 0.07 Pain Relevance 0.29
Pretreatment with morphine (3 and 10 mg/kg, i.p.) significantly reduced the induction of Fos-IR neurons at the superficial layers of the ipsilateral SpVc in a dose-dependent manner, and its effect was antagonized by the subsequent treatment of naloxone (2 mg/kg, i.p.).
Negative_regulation (reduced) of Positive_regulation (induction) of Fos-IR in neurons associated with narcan and morphine
5) Confidence 0.41 Published 1999 Journal Brain Res. Section Abstract Doc Link 10082860 Disease Relevance 0.05 Pain Relevance 0.43
Dyn A-IR, but not LE-IR, was also significantly depleted in some forebrain nuclei in all experimental groups as compared with intact controls, whereas Dyn A-IR in the hypothalamic ventromedial nucleus was elevated only in the sham-control rats.
Negative_regulation (depleted) of Positive_regulation (elevated) of A-IR in nucleus
6) Confidence 0.35 Published 1985 Journal Am. J. Physiol. Section Abstract Doc Link 2863984 Disease Relevance 0.50 Pain Relevance 0.28
When the vagus nerve was crushed above the nodose ganglion, the accumulation of IR-SS in the proximal segment was reduced by 50%, although the IR-SS content in the nodose ganglion and in the intervening nerve segments was unchanged by this procedure.
Negative_regulation (reduced) of Positive_regulation (accumulation) of IR-SS in nerve associated with ganglion cysts, somatostatin and vagus nerve
7) Confidence 0.34 Published 1984 Journal Endocrinology Section Abstract Doc Link 6200314 Disease Relevance 0.26 Pain Relevance 0.80
Denervation prevented the increase of ME-IR concentration induced by the injection of Freund's adjuvant.
Negative_regulation (prevented) of Positive_regulation (increase) of ME-IR
8) Confidence 0.32 Published 1984 Journal Pain Section Abstract Doc Link 6324054 Disease Relevance 0.43 Pain Relevance 0.84
The results were as follows: (1) After icv or intra-DR (dorsal raphe nucleus) injection of 5-HTP, the content of Ir-SP in hypothalamus significantly decreased and pain threshold markedly increased; After depletion of the 5-HT content in brain by pCPA or destruction of DR, the contents of Ir-SP were remarkably elevated in three brain regions by the former and in hypothalamus, striatum by the later. (2) The Ir-SP levels in the three brain regions and the pain threshold were not affected by the icv injection of NE, however, icv injection of DA caused a increase of Ir-SP concentration in striatum which was reversed by the DA receptor antagonist haloperidol, but without any change of the pain threshold. 7th day after icv injection of 6-OHDA, the content of Ir-SP in striatum significantly reduced. (3) Icv injection of met-enkephalin (MEK) or morphine could increase the Ir-SP levels in hypothalamus, striatum and the pain threshold, and above-mentioned effect of morphine could be prevented by the opioid receptor antagonist naloxone.
Negative_regulation (reversed) of in brain Positive_regulation (increase) of Ir-SP in hypothalamus associated with pain threshold, antagonist, narcan, opioid receptor, enkephalin, raphe and morphine
9) Confidence 0.24 Published 1990 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 1703464 Disease Relevance 0.53 Pain Relevance 1.70
SR 141716 attenuated morphine-induced Fos-IR in several regions including the CPu, cortex, NAS (shell), LS, MnPO, MPO, paraventricular and dorsomedial hypothalamus, PV, basolateral amygdala, VTA, and Edinger-Westphal nucleus (EW).
Negative_regulation (attenuated) of Positive_regulation (induced) of Fos-IR in MPO associated with ventral tegmentum, nucleus accumbens, urological neuroanatomy, amygdala and morphine
10) Confidence 0.22 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 15567425 Disease Relevance 0.26 Pain Relevance 1.31
Conversely, THC pre-exposure reduced heroin-induced Fos-IR in the BNST, CEA, and the PAG (dorsolateral and lateral).
Negative_regulation (reduced) of Positive_regulation (heroin-induced) of Fos-IR in lateral associated with urological neuroanatomy and amygdala
11) Confidence 0.21 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 16137723 Disease Relevance 0.28 Pain Relevance 0.44
Conversely, THC pre-exposure reduced heroin-induced Fos-IR in the BNST, CEA, and the PAG (dorsolateral and lateral).
Negative_regulation (reduced) of Positive_regulation (heroin-induced) of Fos-IR in lateral associated with urological neuroanatomy and amygdala
12) Confidence 0.21 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 16137723 Disease Relevance 0.28 Pain Relevance 0.44
SR 141716 attenuated morphine-induced Fos-IR in several regions including the CPu, cortex, NAS (shell), LS, MnPO, MPO, paraventricular and dorsomedial hypothalamus, PV, basolateral amygdala, VTA, and Edinger-Westphal nucleus (EW).
Negative_regulation (attenuated) of Positive_regulation (morphine-induced) of Fos-IR in MPO associated with ventral tegmentum, nucleus accumbens, urological neuroanatomy, amygdala and morphine
13) Confidence 0.16 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 15567425 Disease Relevance 0.26 Pain Relevance 1.31
SR 141716 attenuated morphine-induced Fos-IR in several regions including the CPu, cortex, NAS (shell), LS, MnPO, MPO, paraventricular and dorsomedial hypothalamus, PV, basolateral amygdala, VTA, and Edinger-Westphal nucleus (EW).
Negative_regulation (attenuated) of in MnPO Positive_regulation (induced) of Fos-IR in MPO associated with ventral tegmentum, nucleus accumbens, urological neuroanatomy, amygdala and morphine
14) Confidence 0.08 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 15567425 Disease Relevance 0.26 Pain Relevance 1.31
SR 141716 attenuated morphine-induced Fos-IR in several regions including the CPu, cortex, NAS (shell), LS, MnPO, MPO, paraventricular and dorsomedial hypothalamus, PV, basolateral amygdala, VTA, and Edinger-Westphal nucleus (EW).
Negative_regulation (attenuated) of in MnPO Positive_regulation (morphine-induced) of Fos-IR in MPO associated with ventral tegmentum, nucleus accumbens, urological neuroanatomy, amygdala and morphine
15) Confidence 0.05 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 15567425 Disease Relevance 0.26 Pain Relevance 1.31
I.t. administration of AM(22-52) (10 nmol) also reversed CFA-induced increase in AM-IR in the spinal dorsal horn and DRG.
Negative_regulation (reversed) of Positive_regulation (increase) of AM-IR in spinal associated with dorsal root ganglion and spinal dorsal horn
16) Confidence 0.04 Published 2009 Journal Pain Section Abstract Doc Link 19683388 Disease Relevance 0.93 Pain Relevance 0.97

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