INT147692

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 28
Disease Relevance 7.17
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Epc1) nucleus (Epc1)
Anatomy Link Frequency
bone marrow 5
hindlimb 2
lung 2
left lung 2
HGF 1
Epc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 163 97.48 Very High Very High Very High
Inflammation 128 96.88 Very High Very High Very High
imagery 18 94.60 High High
halothane 30 93.20 High High
anesthesia 37 92.48 High High
agonist 7 89.52 High High
Pain 11 89.28 High High
Angina 1 76.80 Quite High
Thoracotomy 18 72.84 Quite High
COX-2 inhibitor 7 55.48 Quite High
Disease Link Frequency Relevance Heat
Adult Respiratory Distress Syndrome 150 99.92 Very High Very High Very High
Adhesions 49 99.92 Very High Very High Very High
Hypoxia 127 99.32 Very High Very High Very High
Cv Unclassified Under Development 169 97.48 Very High Very High Very High
INFLAMMATION 174 96.88 Very High Very High Very High
Injury 61 96.36 Very High Very High Very High
Cancer 53 95.00 High High
Myocardial Infarction 57 94.20 High High
Atherosclerosis 245 93.68 High High
Diabetes Mellitus 43 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to mature EC that compose the adult vasculature, EPC are supposed to be released from the bone marrow into the peripheral blood after stimulation by distinct inflammatory injuries [3,44].
Localization (released) of EPC in blood associated with inflammation and injury
1) Confidence 0.40 Published 2007 Journal Respir Res Section Body Doc Link PMC2000890 Disease Relevance 0.33 Pain Relevance 0.05
In this paper, we review the role of statins in EPC mobilization, its effect in endothelial function restoration and the relevance of this finding in cardiovascular risk.
Localization (mobilization) of EPC
2) Confidence 0.39 Published 2007 Journal Cardiovascular & hematological agents in medicinal chemistry Section Abstract Doc Link 17979688 Disease Relevance 0.23 Pain Relevance 0.12
Intravenous application of EPC was performed 50 to 120 min after reperfusion of the transplanted left lung.


Localization (application) of EPC in left lung
3) Confidence 0.38 Published 2007 Journal Respir Res Section Body Doc Link PMC2000890 Disease Relevance 0 Pain Relevance 0.17
Intravenous application of EPC was performed 50 to 120 min after reperfusion of the transplanted left lung (n = 9).
Localization (application) of EPC in left lung
4) Confidence 0.38 Published 2007 Journal Respir Res Section Body Doc Link PMC2000890 Disease Relevance 0.15 Pain Relevance 0.32
In all lung sections investigated we were able to detect injected EPC at a number of about 10 to 15 cells per slide.
Localization (detect) of EPC in lung
5) Confidence 0.35 Published 2007 Journal Respir Res Section Body Doc Link PMC2000890 Disease Relevance 0.37 Pain Relevance 0.08
EPC were localized in vessel walls as well as in destructed lung tissue.
Localization (localized) of EPC in lung
6) Confidence 0.35 Published 2007 Journal Respir Res Section Abstract Doc Link PMC2000890 Disease Relevance 0.37 Pain Relevance 0.03
Besides mature endothelial cells (EC) that compose the adult vasculature, endothelial progenitor cells (EPC) are supposed to be released from the bone marrow into the peripheral blood after stimulation by distinct inflammatory injuries.
Localization (released) of EPC in vasculature associated with inflammation and injury
7) Confidence 0.35 Published 2007 Journal Respir Res Section Abstract Doc Link PMC2000890 Disease Relevance 0.34 Pain Relevance 0.05
Although the aim of this work was not the identification of the molecular effectors responsible for the angiogenic properties of EPC-CM, we have confirmed that EPC release key angiogenic molecules such as Angiogenin, HGF, IL-8, PDGF, SDF-1 and VEGF in culture.
Localization (release) of EPC in HGF
8) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682571 Disease Relevance 0.22 Pain Relevance 0.03
However, despite the fact that the regenerative capacity of EPC-secreted factors is recognized [23] the spectrum of paracrine effectors and their mechanisms of action remain largely unexplored.
Localization (-) of EPC
9) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682571 Disease Relevance 0.06 Pain Relevance 0.03
However, despite the fact that the regenerative capacity of EPC-secreted factors is recognized [23] the spectrum of paracrine effectors and their mechanisms of action remain largely unexplored.
Localization (secreted) of EPC
10) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682571 Disease Relevance 0.06 Pain Relevance 0.03
We hypothesized that the regenerative potential of paracrine factors secreted by EPC may represent a potent alternative to progenitor cell therapy.


Localization (secreted) of EPC
11) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682571 Disease Relevance 0.42 Pain Relevance 0
We tested the hypothesis that cell-free administration of paracrine factors secreted by cultured EPC may achieve an angiogenic effect equivalent to cell therapy.


Localization (secreted) of EPC
12) Confidence 0.30 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2682571 Disease Relevance 0.23 Pain Relevance 0.03
Preclinical studies have described that EPC secretion of factors involved in the regulation of stem cell recruitment and in vascular growth and remodeling (such as SDF-1, VEGF, HGF and MMP-9) [5], [17] support the function of mature endothelial cells in vitro and tissue regeneration in a variety of animal models [21], [22].
Localization (secretion) of EPC in endothelial cells
13) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682571 Disease Relevance 0.07 Pain Relevance 0.04
Recently the characterization of multifaceted nature of the EPC secretome has been addressed [16] but further investigations are needed to clarify the activation and the interactions of downstream signals.
Localization (secretome) of EPC
14) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682571 Disease Relevance 0.17 Pain Relevance 0.03
In the present study we demonstrate that paracrine factors released by in vitro expanded EPC have a potent therapeutic capacity in a rat model of hindlimb ischemia.
Localization (released) of EPC in hindlimb associated with ischemia
15) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682571 Disease Relevance 0.10 Pain Relevance 0.05
In conclusion, we have demonstrated in the present study that the constellation of soluble factors secreted by in vitro expanded EPC is able to support revascularization of hindlimb ischemic tissue.
Localization (secreted) of EPC in hindlimb
16) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682571 Disease Relevance 0.15 Pain Relevance 0
Secretion of growth factors by EPC is increased by hypoxia
Localization (Secretion) of EPC associated with hypoxia
17) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682571 Disease Relevance 0.49 Pain Relevance 0
Furthermore, EPC-CM transplantation stimulated the mobilization of bone marrow (BM)-derived EPC compared to control (678.7±44.1 vs. 340.0±29.1 CD34+/CD45?
Localization (mobilization) of EPC in bone marrow
18) Confidence 0.27 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2682571 Disease Relevance 0.22 Pain Relevance 0.04
CONCLUSION: The higher EPC counts during painful crisis might indicate a role for EPC mobilization in reendothelialization.
Localization (mobilization) of EPC
19) Confidence 0.19 Published 2009 Journal Exp. Hematol. Section Body Doc Link 19539689 Disease Relevance 0.12 Pain Relevance 0
As a relationship of EPCs with the established mobilizing growth factors, measured in this study was not observed, the mechanism of EPC mobilization in SCD remains to be elucidated.


Localization (mobilization) of EPC
20) Confidence 0.19 Published 2009 Journal Exp. Hematol. Section Body Doc Link 19539689 Disease Relevance 0.10 Pain Relevance 0

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