INT14770

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Context Info
Confidence 0.60
First Reported 1983
Last Reported 1991
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.10
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2a) plasma membrane (Adra2a) cytoplasm (Adra2a)
signal transducer activity (Adra2a)
Anatomy Link Frequency
pancreatic islets 1
Adra2a (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 7 100.00 Very High Very High Very High
agonist 6 100.00 Very High Very High Very High
antagonist 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Obesity 1 98.04 Very High Very High Very High
Bordatella Infection 2 41.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Epinephrine, norepinephrine or the more selective alpha-2 adrenoceptor agonist, clonidine, inhibited insulin release from isolated pancreatic islets of lean mice or obese mice homozygous for the gene ob.
Localization (release) of alpha-2 adrenoceptor in pancreatic islets associated with obesity, agonist and clonidine
1) Confidence 0.60 Published 1983 Journal Acta Physiol. Scand. Section Abstract Doc Link 6137936 Disease Relevance 0.10 Pain Relevance 0.49
Using a cultured SV40-transformed hamster beta-cell line (HIT cells) as a model system, we determined the effect of alpha 2-adrenergic agonists on insulin secretion, 86Rb+ efflux (a marker for K+ channel flux), and the free cytosolic Ca2+ level [( Ca2+]i) monitored in fura-2-loaded cells.
Localization (secretion) of alpha 2-adrenergic associated with agonist
2) Confidence 0.01 Published 1991 Journal Endocrinology Section Abstract Doc Link 1703486 Disease Relevance 0 Pain Relevance 0.29

General Comments

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