INT147713

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Context Info
Confidence 0.70
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) cell adhesion (Ephb1)
plasma membrane (Ephb1) kinase activity (Ephb1) cytoplasm (Ephb1)
Ephb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Desipramine 24 99.66 Very High Very High Very High
local anesthetic 12 98.16 Very High Very High Very High
lidocaine 4 92.20 High High
Hippocampus 6 79.52 Quite High
antidepressant 2 28.96 Quite Low
Disease Link Frequency Relevance Heat
Convulsion 2 32.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antagonistic actions of local anesthetics against NET down-regulation by desipramine were related to alterations of the cell-surface localization of NET.
Localization (localization) of NET associated with desipramine and local anesthetic
1) Confidence 0.70 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 17981365 Disease Relevance 0 Pain Relevance 0.71
These results indicate that the NET down-regulation indicated by the reduction of [(3)H]nisoxetine binding was induced by administration of desipramine via decrease of NET localization on the cell surface.
Localization (localization) of NET associated with desipramine
2) Confidence 0.70 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 17981365 Disease Relevance 0 Pain Relevance 0.83

General Comments

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