INT147715

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 2005
Last Reported 2010
Negated 7
Speculated 3
Reported most in Body
Documents 6
Total Number 11
Disease Relevance 5.26
Pain Relevance 7.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ephb1) signal transduction (Ephb1) cell adhesion (Ephb1)
plasma membrane (Ephb1) kinase activity (Ephb1) cytoplasm (Ephb1)
Anatomy Link Frequency
brain 6
neurons 4
paw 2
ganglion cells 2
reservoir 2
Ephb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Desipramine 49 100.00 Very High Very High Very High
B1 receptor 27 100.00 Very High Very High Very High
local anesthetic 24 99.98 Very High Very High Very High
Hippocampus 12 99.92 Very High Very High Very High
Pain 245 99.04 Very High Very High Very High
lidocaine 8 95.64 Very High Very High Very High
Action potential 18 94.40 High High
Dopamine 200 88.48 High High
hyperexcitability 24 87.52 High High
antagonist 17 87.36 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 21 99.14 Very High Very High Very High
Pain 260 99.04 Very High Very High Very High
Cancer 228 98.78 Very High Very High Very High
Urological Neuroanatomy 4 96.56 Very High Very High Very High
Convulsion 4 84.48 Quite High
Nervous System Injury 55 84.40 Quite High
Skin Cancer 24 75.04 Quite High
Anxiety Disorder 2 67.12 Quite High
Vomiting 2 66.40 Quite High
Sleep Disorders 3 65.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NET protein expression in the whole cell fraction and membrane fraction was not affected by treatment with any drugs.
Neg (not) Regulation (affected) of Gene_expression (expression) of NET protein
1) Confidence 0.62 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 17981365 Disease Relevance 0.05 Pain Relevance 1.13
The present study aimed to elucidate whether chronic treatment with desipramine regulates the expression of NET protein examined in membrane fractions in various brain regions and whether co-administration of local anesthetics affects the desipramine-induced alteration of NET expression.
Spec (whether) Regulation (alteration) of Gene_expression (expression) of NET in brain associated with desipramine and local anesthetic
2) Confidence 0.62 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 17981365 Disease Relevance 0.08 Pain Relevance 1.02
However, CCI treatment did not significantly alter these properties of the DRG neurons from EphB1+/- and EphB1-/- mice.
Neg (not) Regulation (alter) of Gene_expression (/) of EphB1 in neurons
3) Confidence 0.45 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 0.85 Pain Relevance 0.76
However, CCI treatment did not significantly alter these properties of the DRG neurons from EphB1+/- and EphB1-/- mice.
Neg (not) Regulation (alter) of Gene_expression (/) of EphB1 in neurons
4) Confidence 0.45 Published 2008 Journal Mol Pain Section Body Doc Link PMC2605438 Disease Relevance 0.79 Pain Relevance 0.76
The present study aimed to elucidate whether chronic treatment with desipramine regulates the expression of NET protein examined in membrane fractions in various brain regions and whether co-administration of local anesthetics affects the desipramine-induced alteration of NET expression.
Spec (whether) Regulation (affects) of Gene_expression (expression) of NET in brain associated with desipramine and local anesthetic
5) Confidence 0.27 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 17981365 Disease Relevance 0.08 Pain Relevance 1.02
The present study aimed to elucidate whether chronic treatment with desipramine regulates the expression of NET protein examined in membrane fractions in various brain regions and whether co-administration of local anesthetics affects the desipramine-induced alteration of NET expression.
Regulation (regulates) of Spec (examined) Gene_expression (expression) of NET protein in brain associated with desipramine and local anesthetic
6) Confidence 0.24 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 17981365 Disease Relevance 0.08 Pain Relevance 0.89
at 300 pg/paw had no effect on either ephrin B1 or Eph B1 receptor gene expression.


Neg (no) Regulation (effect) of Gene_expression (expression) of Eph B1 receptor gene in paw associated with b1 receptor
7) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 0.88 Pain Relevance 0.49
The gene expression of the Eph B1 receptor was unchanged in all of the test groups (Figure 2B).


Neg (unchanged) Regulation (unchanged) of Gene_expression (expression) of Eph B1 receptor associated with b1 receptor
8) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.10 Pain Relevance 0.69
The repeated administration of devazepide significantly suppressed the expression of the ephrin B1 gene compared with the vehicle-treated group in cancer-induced pain mice (p < 0.01) (Figure 6A); however, the gene expression of the Eph B1 receptor was unchanged in all of the test groups (Figure 6B).
Neg (unchanged) Regulation (unchanged) of Gene_expression (expression) of Eph B1 receptor associated with pain, cancer and b1 receptor
9) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 0.97 Pain Relevance 0.47
The transcription factor Zic2 is expressed in uncrossed (iRGCs) but not in crossed (cRGCs) ganglion cells, and is necessary and sufficient to control the expression of the guidance receptor EphB1 (Herrera et al, 2003; Garcia-Frigola et al, 2008).
Regulation (control) of Gene_expression (expression) of EphB1 in ganglion cells associated with ganglion cysts
10) Confidence 0.17 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.10 Pain Relevance 0
As opposed to the DAT, NET expression is not altered in DAT-KO mice so that the storage pool, which is by far the predominant reservoir of NE in NE-enriched regions such as the frontal cortex, should not be significantly altered in these mutants.
Neg (not) Regulation (altered) of Gene_expression (expression) of NET in reservoir associated with urological neuroanatomy
11) Confidence 0.10 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.27 Pain Relevance 0.26

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox