INT147718

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Context Info
Confidence 0.50
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 2.61
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Cspg4) cell proliferation (Cspg4) plasma membrane (Cspg4)
intracellular (Cspg4) signal transducer activity (Cspg4)
Anatomy Link Frequency
brain 2
spinal cord 1
microglia 1
Cspg4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 88 99.48 Very High Very High Very High
ASIC 171 99.46 Very High Very High Very High
tetrodotoxin 5 99.22 Very High Very High Very High
ischemia 33 97.82 Very High Very High Very High
imagery 17 82.56 Quite High
Hippocampus 19 81.28 Quite High
Dorsal column 30 80.08 Quite High
Central nervous system 28 75.08 Quite High
sodium channel 3 75.00 Quite High
allodynia 22 50.00 Quite Low
Disease Link Frequency Relevance Heat
Spinal Cord Injury 67 99.48 Very High Very High Very High
Epilepsy 12 98.08 Very High Very High Very High
Cv Unclassified Under Development 25 97.82 Very High Very High Very High
Injury 144 97.30 Very High Very High Very High
Acidosis 9 96.14 Very High Very High Very High
Convulsion 9 93.88 High High
Brain Hemorrhage 5 93.36 High High
Neurological Disease 6 92.36 High High
Cicatrix 12 88.64 High High
Cv General 4 Under Development 4 88.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that a TTX sensitive I(Na) component in NG2 glia contributes significantly to the depolarized NG2 glia RMP in the developing brain.
Positive_regulation (contributes) of NG2 in brain associated with tetrodotoxin
1) Confidence 0.50 Published 2007 Journal Neuroscience Section Abstract Doc Link 17981402 Disease Relevance 0 Pain Relevance 0.43
NG2 positive cells are generally considered as OPCs, although NG2 can be induced in activated microglia [5], [38], [39], [40], [41].
Positive_regulation (induced) of NG2 in microglia
2) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884017 Disease Relevance 0.47 Pain Relevance 0.05
Neurocan and NG2 are axon-growth-inhibitory CSPGs [42,43] that are upregulated at sites of spinal cord injury [18,44,45] and whose suppression has been shown to correlate with the ability of adult sensory axons to cross acute spinal cord injuries [46].
Positive_regulation (upregulated) of NG2 in spinal cord associated with spinal cord
3) Confidence 0.27 Published 2008 Journal J Biol Section Body Doc Link PMC2776404 Disease Relevance 0.91 Pain Relevance 0.28
We thus examined whether activation of ASIC channels leads to [Ca2+]i elevation in NG2 cells (Fig. 5A).
Spec (whether) Positive_regulation (elevation) of NG2 associated with asic
4) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937019 Disease Relevance 0 Pain Relevance 0.18
Given that acidosis is a common feature of brain in acute neurological injury, particularly in ischemia and epilepsy, we thus hypothesize that a drop in pH may be the linkage between the pathological process and activation of NG2 cells.
Positive_regulation (activation) of NG2 in brain associated with epilepsy, acidosis, ischemia and injury
5) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2937019 Disease Relevance 0.86 Pain Relevance 0.33
It is postulated that a drop in pH may be the link between the pathological process and activation of NG2 cells.
Positive_regulation (activation) of NG2
6) Confidence 0.14 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2937019 Disease Relevance 0.37 Pain Relevance 0.26

General Comments

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