INT147731

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.93
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CA) signal transduction (PIK3CA)
Anatomy Link Frequency
plasma 1
PIK3CA (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 1 90.48 High High
antagonist 1 89.92 High High
Inflammation 29 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Neuropathic pain 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 110 98.24 Very High Very High Very High
Death 9 94.52 High High
Cancer 103 94.08 High High
Skin Cancer 4 93.28 High High
Lung Cancer 3 84.68 Quite High
Carcinoma 95 83.00 Quite High
Malignant Neoplastic Disease 4 81.64 Quite High
Sarcoma 2 73.56 Quite High
Breast Cancer 24 71.60 Quite High
Wound Healing 1 67.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Active PI3K generates the phosphorylated lipid phosphatidylinositol-3,4,5-triphosphate (PtdIns(3,4,5)P3), leading to the recruitment and activation of other kinases such as Akt (protein kinase B) to the plasma membrane.
Phosphorylation (phosphorylated) of PI3K in plasma
1) Confidence 0.44 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.36 Pain Relevance 0
However, resistance to trastuzumab is frequent [6] and its mechanisms are poorly understood [7], although ERBB2 phosphorylation [8], PTEN and PIK3CA status [9] seem important factors.
Phosphorylation (phosphorylation) of PIK3CA
2) Confidence 0.24 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.25 Pain Relevance 0
This effect was regulated by early phosphorylation of FAK and subsequent PI-3K and Rac1 activation.
Phosphorylation (phosphorylation) of PI-3K
3) Confidence 0.14 Published 2007 Journal Cell. Physiol. Biochem. Section Abstract Doc Link 17982280 Disease Relevance 0.32 Pain Relevance 0.14

General Comments

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