INT147732

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Context Info
Confidence 0.36
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.13
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CA) signal transduction (PIK3CA)
Anatomy Link Frequency
epithelial cells 1
PIK3CA (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 2 83.52 Quite High
cytokine 2 82.00 Quite High
Opioid 1 55.92 Quite High
tolerance 7 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 1 99.12 Very High Very High Very High
Breast Cancer 36 99.00 Very High Very High Very High
Cancer 56 90.60 High High
Hyperinsulinism 2 85.32 High High
Skin Cancer 2 58.72 Quite High
Diabetes Mellitus 7 58.08 Quite High
Hematologic Neoplasms 2 57.68 Quite High
Solid Tumor 2 56.44 Quite High
Insulin Resistance 24 50.00 Quite Low
Targeted Disruption 8 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ala mice also showed an increased association between IRS-1 and the p85 subunit of PI3-kinase, which reflects increased interaction between IRS-1 and PI 3-kinase likely due to the Ser612?
PI 3-kinase Binding (interaction) of
1) Confidence 0.36 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.14 Pain Relevance 0.08
In addition to ER, a number of other HSP90 client proteins have been shown to be involved in breast cancer progression such as those that are important for signaling through the phosphahtidylinositol-3-kinase (PI3K/p110?)
PI3K Binding (signaling) of associated with breast cancer
2) Confidence 0.10 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397535 Disease Relevance 0.75 Pain Relevance 0.04
We have recently identified a specific signaling pathway that regulates actin reorganization in malignant human breast and prostate epithelial cells associated with FAK, PI-3K and Rac1 activation.
PI-3K Binding (associated) of in epithelial cells associated with malignant neoplastic disease
3) Confidence 0.08 Published 2007 Journal Cell. Physiol. Biochem. Section Abstract Doc Link 17982280 Disease Relevance 0.23 Pain Relevance 0.08

General Comments

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