INT147734

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Context Info
Confidence 0.64
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.33
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RAC1) cell motility (RAC1) cell adhesion (RAC1)
plasma membrane (RAC1) enzyme binding (RAC1) GTPase activity (RAC1)
RAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 1 91.20 High High
antagonist 1 90.64 High High
aspirin 9 90.32 High High
cINOD 2 63.60 Quite High
Inflammation 1 60.00 Quite High
agonist 1 47.20 Quite Low
Kinase C 2 5.00 Very Low Very Low Very Low
peptic ulcer disease 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 1 94.00 High High
Apoptosis 4 92.52 High High
Lung Cancer 2 82.12 Quite High
Malignant Neoplastic Disease 1 81.64 Quite High
Cancer 15 75.00 Quite High
Adhesions 5 74.80 Quite High
Wound Healing 1 68.32 Quite High
Cardiovascular Disease 1 67.76 Quite High
Colon Cancer 1 66.68 Quite High
INFLAMMATION 2 63.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The involvement of PI3K/Akt inhibition and p27 upregulation, as well as hypophosphorylation of Rac1 at ser71, were demonstrated.
Phosphorylation (hypophosphorylation) of Rac1
1) Confidence 0.64 Published 2010 Journal Mol. Carcinog. Section Abstract Doc Link 19908241 Disease Relevance 0.93 Pain Relevance 0.45
This effect was regulated by early phosphorylation of FAK and subsequent PI-3K and Rac1 activation.
Phosphorylation (phosphorylation) of Rac1
2) Confidence 0.53 Published 2007 Journal Cell. Physiol. Biochem. Section Abstract Doc Link 17982280 Disease Relevance 0.32 Pain Relevance 0.14
Akt1 phosphorylates a single serine residue of Rac1 [39].
Phosphorylation (phosphorylates) of Rac1
3) Confidence 0.09 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2254585 Disease Relevance 0.07 Pain Relevance 0

General Comments

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