INT14778

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Context Info
Confidence 0.75
First Reported 1991
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 25
Total Number 26
Disease Relevance 16.25
Pain Relevance 3.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (FCGR3A) plasma membrane (FCGR3A)
Anatomy Link Frequency
NK cells 6
neutrophils 4
macrophages 2
lymphocytes 1
brains 1
FCGR3A (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 68 100.00 Very High Very High Very High
methotrexate 17 100.00 Very High Very High Very High
Central nervous system 21 99.36 Very High Very High Very High
drug abuse 16 99.36 Very High Very High Very High
spinal inflammation 5 98.38 Very High Very High Very High
Spinal cord 15 97.16 Very High Very High Very High
Pain 8 96.32 Very High Very High Very High
endometriosis 156 94.44 High High
Inflammation 13 90.40 High High
cINOD 10 90.08 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 68 100.00 Very High Very High Very High
Infection 21 99.60 Very High Very High Very High
Atherosclerosis 27 99.52 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 46 99.40 Very High Very High Very High
Drug Dependence 16 99.36 Very High Very High Very High
Multiple Myeloma 3 99.26 Very High Very High Very High
Viral Meningitis 28 99.12 Very High Very High Very High
Low Back Pain 6 98.38 Very High Very High Very High
Cicatrix 141 97.88 Very High Very High Very High
Endometriosis 270 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expressions of CD3(+), CD3(+)CD4(+), CD3(+)CD8(+), CD3(-)CD16(+)CD56(+), and CD3(+)CD25(+) were measured as percentages of total lymphocytes by flow cytometer at 5 time points.
Gene_expression (Expressions) of CD16 in lymphocytes
1) Confidence 0.75 Published 2006 Journal Clin. Chim. Acta Section Body Doc Link 16487501 Disease Relevance 0.08 Pain Relevance 0
Although neutrophil chemotaxis, superoxide production, and FcRIII surface expression were reduced, the patient improved clinically after restoration of a normal neutrophil count.
Gene_expression (expression) of FcRIII in neutrophil
2) Confidence 0.74 Published 1991 Journal J. Pediatr. Section Abstract Doc Link 1704431 Disease Relevance 0.37 Pain Relevance 0.10
In contrast, neutrophils express FcgammaRIIIb.
Gene_expression (express) of FcgammaRIIIb in neutrophils
3) Confidence 0.71 Published 2006 Journal Atherosclerosis Section Abstract Doc Link 16310791 Disease Relevance 0.63 Pain Relevance 0.06
METHODS: Using flow cytometric assay of whole human blood, we investigated direct effects of endogenous and synthetic opioid peptides on surface expression of complement receptors CD35 and CD11b/CD18 and Fcã receptor III CD16, and superoxide anion generation of neutrophils.
Gene_expression (expression) of CD16 in neutrophils
4) Confidence 0.65 Published 2003 Journal Br J Anaesth Section Body Doc Link 14504158 Disease Relevance 0.09 Pain Relevance 0
Numerous studies have analysed the possible association between FCGR2A and FCGR3A polymorphisms and the efficacy of biological agents against TNF?
Gene_expression (polymorphisms) of FCGR3A
5) Confidence 0.64 Published 2011 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC3015102 Disease Relevance 0.50 Pain Relevance 0.38
In order to create a multivariate model of potential predictors of infusion reactions, we first screened a series of baseline variables which included age, gender, duration of RA, DAS score, levels of CRP, MMP-3, HAQ-DI, RF and antinuclear antibody, doses of MTX and prednisolone equivalent, glucocorticoid use and FCGR3A V/V+V/F and FCGR3B NA1/NA1 genotypes by univariate logistic regression.
Gene_expression (duration) of FCGR3A associated with rheumatoid arthritis and methotrexate
6) Confidence 0.64 Published 2011 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC3015102 Disease Relevance 0.10 Pain Relevance 0.18
The cells express Fcgamma receptor type IIIa (FcgammaRIIIa: CD16) identical to that in natural killer cells (NK cells), but with a cell type-specific glycosylation.
Gene_expression (express) of FcgammaRIIIa in NK cells
7) Confidence 0.58 Published 2006 Journal Atherosclerosis Section Abstract Doc Link 16310791 Disease Relevance 0.55 Pain Relevance 0
The cells express Fc gamma RIIIa (CD16) identical to that in NK cells, but with a cell type-specific glycosylation.
Gene_expression (express) of CD16 in NK cells
8) Confidence 0.57 Published 2003 Journal Rinsho Byori Section Abstract Doc Link 14679789 Disease Relevance 0.21 Pain Relevance 0
The cells express Fc gamma RIIIa (CD16) identical to that in NK cells, but with a cell type-specific glycosylation.
Gene_expression (express) of Fc gamma RIIIa in NK cells
9) Confidence 0.57 Published 2003 Journal Rinsho Byori Section Abstract Doc Link 14679789 Disease Relevance 0.21 Pain Relevance 0
The cells express Fcgamma receptor type IIIa (FcgammaRIIIa: CD16) identical to that in natural killer cells (NK cells), but with a cell type-specific glycosylation.
Gene_expression (express) of CD16 in NK cells
10) Confidence 0.55 Published 2006 Journal Atherosclerosis Section Abstract Doc Link 16310791 Disease Relevance 0.55 Pain Relevance 0
[Soluble Fc gamma RIIIa derived from macrophages].
Gene_expression (derived) of Fc gamma RIIIa in macrophages
11) Confidence 0.49 Published 2003 Journal Rinsho Byori Section Title Doc Link 14679789 Disease Relevance 0.54 Pain Relevance 0.06
[A case of multiple myeloma showing marked differences in serum IgG levels between protein electrophoresis and turbidimetry].
Gene_expression (levels) of IgG associated with multiple myeloma
12) Confidence 0.40 Published 2008 Journal The Korean journal of laboratory medicine Section Title Doc Link 18728377 Disease Relevance 0.37 Pain Relevance 0.24
Five-micrometer sections from each case were stained to visualize expression of RCAS1, MT and CD16-, CD25-, CD69-, CD56-positive cells (mainly lymphocytes) as well as CD68+ cells, or macrophages.
Gene_expression (expression) of CD16 in macrophages
13) Confidence 0.24 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 0.41 Pain Relevance 0.06
No differences in CD16 antigen expression were observed between the studied tissue samples and the control group.


Gene_expression (expression) of CD16
14) Confidence 0.24 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1574328 Disease Relevance 1.68 Pain Relevance 0.41
Metallothionein, RCAS1, CD25, CD69, CD56, CD16, CD68 antigen expression was assessed by immunohistochemistry in ovarian and scar endometriomas tissue samples which were obtained from 33 patients.
Gene_expression (expression) of CD16 associated with endometriosis and cicatrix
15) Confidence 0.24 Published 2006 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1574328 Disease Relevance 1.10 Pain Relevance 0
We find no evidence of microglial proliferation in any of our study groups, including HIVE, although HIV infection leads to increased expression of CD16, CD68 and MHC II.
Gene_expression (expression) of CD16 associated with acquired immune deficiency syndrome or hiv infection, viral meningitis and infection
16) Confidence 0.23 Published 2005 Journal Neuropathol. Appl. Neurobiol. Section Abstract Doc Link 15885069 Disease Relevance 1.30 Pain Relevance 0.11
Using high-pressure antigen retrieval and tyramide signal amplification, we find moderately high levels of CD16 expression in the parenchyma of normal brains which is not normally observed using standard avidin/biotin complex (ABC) techniques.
Gene_expression (expression) of CD16 in brains
17) Confidence 0.23 Published 2005 Journal Neuropathol. Appl. Neurobiol. Section Abstract Doc Link 15885069 Disease Relevance 0.95 Pain Relevance 0.10
We find increased expression of MHC II and CD16 in response to drug abuse.
Gene_expression (expression) of CD16 associated with drug abuse
18) Confidence 0.23 Published 2005 Journal Neuropathol. Appl. Neurobiol. Section Abstract Doc Link 15885069 Disease Relevance 1.42 Pain Relevance 0.22
This suggests that a low basal expression of CD16 occurs in many resident microglial cells which may potentially be upregulated in HIV-infected individuals.
Gene_expression (expression) of CD16 in microglial cells associated with acquired immune deficiency syndrome or hiv infection
19) Confidence 0.23 Published 2005 Journal Neuropathol. Appl. Neurobiol. Section Abstract Doc Link 15885069 Disease Relevance 0.99 Pain Relevance 0.10
Levels of serum IgG and IgM anticardiolipin, protein C, protein S, antithrombine III and total homocysteine were within the normal range.
Gene_expression (Levels) of IgG
20) Confidence 0.08 Published 2005 Journal Thromb J Section Body Doc Link PMC1192821 Disease Relevance 0.94 Pain Relevance 0.09

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