INT147788

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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 7.72
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (FUT1) Golgi apparatus (FUT1) carbohydrate metabolic process (FUT1)
Anatomy Link Frequency
hepatocytes 1
stromal cell 1
liver 1
cleavage 1
HSC 1
FUT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Endogenous opioid 2 99.92 Very High Very High Very High
metalloproteinase 9 99.74 Very High Very High Very High
fibrosis 151 98.84 Very High Very High Very High
chemokine 32 97.28 Very High Very High Very High
alcohol 99 90.44 High High
Neurotransmitter 1 89.24 High High
COX2 4 88.84 High High
Inflammation 248 85.92 High High
cytokine 99 84.88 Quite High
ischemia 16 64.72 Quite High
Disease Link Frequency Relevance Heat
Cirrhosis 230 100.00 Very High Very High Very High
Apoptosis 244 99.52 Very High Very High Very High
Fibrosis 210 98.88 Very High Very High Very High
Paroxysmal Nocturnal Hemoglobinuria 158 98.56 Very High Very High Very High
Injury 291 97.60 Very High Very High Very High
Internal Fibrosis 16 93.00 High High
Myeloid Leukemia 58 91.56 High High
Alcoholic Liver Diseases 117 89.00 High High
Aplastic Anemia 15 87.20 High High
Disease 151 86.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A better understanding of the factors that regulate the migration of HSC into the injured kidney is essential for the development of strategies to improve HSC kidney engraftment and repair.
Regulation (regulate) of HSC in HSC
1) Confidence 0.12 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.16 Pain Relevance 0.05
Since these results do not support the current reports on SDF-1-involvement in HSC-migration, we conducted a third independent experiment to determine the effect of local SDF-1 administration on the migration of exogenous HSC.
Spec (determine) Regulation (effect) of HSC
2) Confidence 0.09 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.22 Pain Relevance 0
The chemokine stromal cell-derived factor-1 (SDF-1, also known as CXCL12) and its receptor CXCR4 have been identified as the central signalling axis regulating the trafficking of HSC.
Regulation (regulating) of HSC in stromal cell associated with chemokine
3) Confidence 0.05 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.44 Pain Relevance 0.08
Role of endogenous opioids in modulating HSC activity in vitro and liver fibrosis in vivo.
Regulation (modulating) of HSC in liver associated with fibrosis, cirrhosis and endogenous opioid
4) Confidence 0.05 Published 2008 Journal Gut Section Title Doc Link 17989109 Disease Relevance 0.19 Pain Relevance 0.29
Although these data indicate that single miRNAs may be involved in immature hematopoietic cell function and/or leukemogenesis, no evidence directly supports the contention that miRNAs regulate the function of HSC or LSC.
Regulation (regulate) of HSC in hematopoietic cell
5) Confidence 0.04 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.62 Pain Relevance 0
This differs from what was suggested for ROS [75,77,80,81] and is likely to occur because quiescent HSCs can remove H2O2 less efficiently than fully activated cells [310,312], whereas HSC/MFs are more sensitive to HNE because they lack isoforms of GSH-S-transferase and aldehyde dehydrogenase able to remove or inactivate HNE [288,334].
Regulation (sensitive) of HSC associated with cirrhosis
6) Confidence 0.03 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.19 Pain Relevance 0
In this scenario, the sensitivity of HSCs and HSC/MFs to pro-apoptotic stimuli has been investigated to gain basic knowledge for a putative cell targeted antifibrotic therapy [79-82,91,94,95,244].
Spec (investigated) Regulation (sensitivity) of HSC associated with cirrhosis and apoptosis
7) Confidence 0.03 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.19 Pain Relevance 0.13
With regard to the pro-fibrogenic mechanism, HNE has been shown in human HSC/MFs to elicit transient activation of JNK isoforms and their nuclear translocation as well as to lead to up-regulation of c-Jun and increased AP-1 binding to DNA [288]; a very similar JNK/AP-1-dependent pattern, inducing up-regulation of collagen type I, has been shown to operate in rat HSC/MFs exposed to UV irradiation [309].
Regulation (operate) of HSC
8) Confidence 0.03 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.41 Pain Relevance 0.04
The ACA effect on HSC/MFs was biphasic, with an early phase being mediated by ACA and a late effect due to ACA-induced up-regulation of TGF?
Regulation (effect) of HSC
9) Confidence 0.03 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0 Pain Relevance 0.08
HSC are also regulated in a paracrine manner by acetaldehyde and reactive oxygen species (ROS), produced by the metabolism of ethanol in surrounding hepatocytes.
Regulation (regulated) of HSC in hepatocytes associated with cirrhosis
10) Confidence 0.01 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2898022 Disease Relevance 1.88 Pain Relevance 0.30
In PNH, an antigen-driven immune response targeting the marrow tissue may be postulated, which possibly correlates with the selective expansion of the PIG-A mutated clone; in fact, if the target on HSC membrane is a GPI-linked molecule, PNH HSC may escape this injury while normal HSC are killed.
Regulation (target) of HSC associated with injury and paroxysmal nocturnal hemoglobinuria
11) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721357 Disease Relevance 0.89 Pain Relevance 0.08
Of 2480 compounds screened, 82 compounds were identified that affected HSC number, and of these ten were small molecules with known effects in the prostaglandin pathway [59].
Regulation (affected) of HSC
12) Confidence 0.00 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2912314 Disease Relevance 0.34 Pain Relevance 0.14
Extracellular degradation of matrix proteins is regulated by MMPs produced by HSC, which in turn are regulated by several mechanisms, including gene regulation (transcription and proenzyme synthesis), cleavage of the proenzyme to an active form, and specific inhibition of activated forms by TIMPs [46].
Regulation (regulated) of HSC in cleavage associated with cirrhosis and metalloproteinase
13) Confidence 0.00 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 1.19 Pain Relevance 0.25

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