INT147790

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 4.80
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring glycosyl groups (FUT1) Golgi apparatus (FUT1) carbohydrate metabolic process (FUT1)
Anatomy Link Frequency
blood 2
liver 2
stem cell 2
T cell 2
FUT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 48 99.52 Very High Very High Very High
agonist 54 93.16 High High
alcohol 4 89.48 High High
chemokine 14 85.68 High High
Bile 5 81.84 Quite High
Inflammation 75 80.00 Quite High
Inflammatory response 15 58.64 Quite High
fibrosis 21 50.00 Quite Low
Endogenous opioid 6 50.00 Quite Low
ischemia 12 29.44 Quite Low
Disease Link Frequency Relevance Heat
Injury 82 99.92 Very High Very High Very High
Coronary Artery Disease 66 98.80 Very High Very High Very High
Disease 46 91.44 High High
Myeloproliferative Disorder 44 90.60 High High
Liver Disease 6 87.12 High High
Myeloid Leukemia 114 85.76 High High
Biliary Liver Cirrhosis 4 85.68 High High
Leukemia 34 84.80 Quite High
Stress 11 84.56 Quite High
Cancer 38 84.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Herein, the authors show that in a mouse model of HSC transplantation, SDF-1 was not required for stem cell homing due to compensatory action via the VLA-4/VCAM-1 interaction [31].
Neg (not) Positive_regulation (required) of Gene_expression (transplantation) of HSC in stem cell
1) Confidence 0.11 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.26 Pain Relevance 0.04
These results suggest that injury is necessary for HSC migration and that SDF-1 alone is not sufficient for migration.
Positive_regulation (necessary) of Gene_expression (migration) of HSC associated with injury
2) Confidence 0.10 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.33 Pain Relevance 0
This is remarkable because histone encoding genes are typically expressed in early HSC, suggesting a shift towards a more differentiated phenotype of CD34+ cells in CAD patients [15].
Positive_regulation (because) of Gene_expression (expressed) of HSC associated with coronary artery disease
3) Confidence 0.06 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 0.66 Pain Relevance 0
However, further experiments will be required to completely exclude other possible explanations for the long-term engraftment of miR-29a–expressing myeloid progenitors, including that long-term engrafted miR-29a–overexpressing CMP and GMP represent the progeny of rare engrafted HSC exhibiting a strongly biased myeloid differentiation potential, and that the transplanted and/or engrafted immunophenotypic myeloid progenitors may represent abnormal HSC with altered surface marker expression.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of HSC
4) Confidence 0.04 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.70 Pain Relevance 0
However, further experiments will be required to completely exclude other possible explanations for the long-term engraftment of miR-29a–expressing myeloid progenitors, including that long-term engrafted miR-29a–overexpressing CMP and GMP represent the progeny of rare engrafted HSC exhibiting a strongly biased myeloid differentiation potential, and that the transplanted and/or engrafted immunophenotypic myeloid progenitors may represent abnormal HSC with altered surface marker expression.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of HSC
5) Confidence 0.04 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839143 Disease Relevance 0.68 Pain Relevance 0
The activation of opioid receptors increased HSC proliferation and collagen accumulation.
Positive_regulation (accumulation) of Gene_expression (proliferation) of HSC
6) Confidence 0.04 Published 2008 Journal Gut Section Body Doc Link 17989109 Disease Relevance 0.08 Pain Relevance 0
The activation of opioid receptors increased HSC proliferation and collagen accumulation.
Positive_regulation (increased) of Gene_expression (proliferation) of HSC
7) Confidence 0.04 Published 2008 Journal Gut Section Body Doc Link 17989109 Disease Relevance 0.08 Pain Relevance 0
CONCLUSIONS: Endogenous opioids released during chronic liver injury participate in the process of liver fibrogenesis by stimulating HSC proliferation and collagen production in a paracrine manner.


Positive_regulation (stimulating) of Gene_expression (production) of HSC in liver
8) Confidence 0.04 Published 2008 Journal Gut Section Body Doc Link 17989109 Disease Relevance 0 Pain Relevance 0
Furthermore, cytokine and oxidant production lead to T cell recruitment, HSC activation and collagen production in the liver of patients with alcoholic steatohepatitis [103].
Positive_regulation (lead) of Gene_expression (production) of HSC in T cell associated with cytokine
9) Confidence 0.04 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 1.28 Pain Relevance 0.50
These studies have direct relevance for clinical patients undergoing stem cell transplants: enhanced blood flow or increased NO signaling might enhance HSC production and engraftment, improving the outcome for transplant patients.


Spec (might) Positive_regulation (enhance) of Gene_expression (production) of HSC in blood
10) Confidence 0.01 Published 2010 Journal Cell Commun Signal Section Body Doc Link PMC2912314 Disease Relevance 0.73 Pain Relevance 0

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