INT147792

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2011
Negated 6
Speculated 6
Reported most in Body
Documents 230
Total Number 237
Disease Relevance 287.13
Pain Relevance 24.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lung 19
macrophages 8
respiratory 8
heart 7
sputum 5
COPD (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 3740 100.00 Very High Very High Very High
metalloproteinase 1186 100.00 Very High Very High Very High
fibrosis 871 100.00 Very High Very High Very High
cytokine 743 100.00 Very High Very High Very High
Inflammatory mediators 259 100.00 Very High Very High Very High
depression 226 100.00 Very High Very High Very High
cva 417 99.62 Very High Very High Very High
palliative 176 99.62 Very High Very High Very High
Inflammatory response 283 99.24 Very High Very High Very High
cINOD 71 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pulmonary Disease 14654 100.00 Very High Very High Very High
Nicotine Addiction 5734 100.00 Very High Very High Very High
INFLAMMATION 4108 100.00 Very High Very High Very High
Disease 2594 100.00 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 1545 100.00 Very High Very High Very High
Dyspnea 1147 100.00 Very High Very High Very High
Asthma 1086 100.00 Very High Very High Very High
Influenza Virus Infection 1070 100.00 Very High Very High Very High
Apnoea 1051 100.00 Very High Very High Very High
Emphysema 963 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As with most disease-focused microarray studies, however, there has been a lack of consistency in the identification of COPD gene expression biomarkers.
Gene_expression (expression) of COPD associated with pulmonary disease and disease
1) Confidence 0.70 Published 2009 Journal Respir Res Section Body Doc Link PMC2678087 Disease Relevance 0.98 Pain Relevance 0
In the very few cases of bronchiectasis and allergic alveolitis that were observed, COPD was also present on these medical claims.
Gene_expression (present) of COPD associated with bronchiectasis, chronic obstructive pulmonary disease and hypersensitivity pneumonitis
2) Confidence 0.65 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2866562 Disease Relevance 1.02 Pain Relevance 0
Communication issues in advanced COPD
Gene_expression (issues) of COPD associated with pulmonary disease
3) Confidence 0.58 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2528206 Disease Relevance 1.11 Pain Relevance 0.27
The key to improving end of life care in COPD patients is to undertake good quality research in this patient group, as it cannot be assumed that research outcomes from other study populations are valid in those with COPD (Field and Cassel 1997; Selecky et al 2005).
Gene_expression (improving) of COPD associated with pulmonary disease
4) Confidence 0.58 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2528206 Disease Relevance 0.27 Pain Relevance 0
Fatigue is inextricably linked to three other common symptoms in COPD, dyspnea, depression and insomnia (Woo 2000; Reishtein 2005).
Gene_expression (depression) of COPD associated with pulmonary disease, depression, fatigue, sleep disorders and dyspnea
5) Confidence 0.58 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2528206 Disease Relevance 1.68 Pain Relevance 0.11
Barriers to good end of life care in COPD
Gene_expression (good) of COPD associated with pulmonary disease
6) Confidence 0.58 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2528206 Disease Relevance 1.17 Pain Relevance 0.10
For many patients, maximal therapy for COPD produces only modest or incomplete relief of disabling symptoms and these symptoms result in a significantly reduced quality of life.
Gene_expression (produces) of COPD associated with pulmonary disease
7) Confidence 0.58 Published 2008 Journal Eur. Respir. J. Section Abstract Doc Link 17989116 Disease Relevance 0.57 Pain Relevance 0.23
Prognosis in COPD is poor and many patients perceive shortcomings in the education they receive about aspects of their condition.
Gene_expression (Prognosis) of COPD associated with pulmonary disease
8) Confidence 0.58 Published 2009 Journal Palliat Med Section Abstract Doc Link 19825897 Disease Relevance 0.63 Pain Relevance 0
Information on COPD, comorbidities, and filled prescriptions was obtained from medical databases.
Gene_expression (Information) of COPD
9) Confidence 0.58 Published 2008 Journal Chest Section Body Doc Link 18339786 Disease Relevance 0.18 Pain Relevance 0
Preliminary evidence suggests that treatment with tiotropium might alter the progression of COPD.
Gene_expression (progression) of COPD associated with pulmonary disease
10) Confidence 0.58 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695619 Disease Relevance 0.66 Pain Relevance 0.04
Stages of COPD
Gene_expression (Stages) of COPD associated with pulmonary disease
11) Confidence 0.57 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2962301 Disease Relevance 1.08 Pain Relevance 0
We observed a lower potential turning point in the evolution of health status in our study population, ie, between stages III and IV, with no significant change in SGRQ total scores marking the progression of COPD from stage I to III.
Gene_expression (progression) of COPD associated with pulmonary disease
12) Confidence 0.57 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2706601 Disease Relevance 0.79 Pain Relevance 0
COPD is common in veterans and was a primary cause of mortality, second only to cancer and vascular disease, in a cohort of retired military Chinese veterans followed over an 18-year period.1 The high prevalence of COPD among veterans might be attributed to the strong association between combat experience and health risk behaviors including smoking,2 which is the major cause of COPD.
Gene_expression (cause) of COPD associated with nicotine addiction, cancer, chronic obstructive pulmonary disease and increased venous pressure under development
13) Confidence 0.57 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2866562 Disease Relevance 1.14 Pain Relevance 0
The dissimilarity in the impact of COPD and obesity on length of hospital stay and cost in cervical spine surgery in males and females can be referred to gender differences in COPD prognosis and BMI connotation as a measure of obesity.
Gene_expression (prognosis) of COPD in spine associated with pulmonary disease and obesity
14) Confidence 0.57 Published 2010 Journal Indian Journal of Orthopaedics Section Body Doc Link PMC2947730 Disease Relevance 1.96 Pain Relevance 0.04
However, review of the scan performed six weeks earlier, during his admission for COPD exacerbation, revealed an area of increased density in the right pulmonary artery stump, consistent with the location of the thrombus.
Gene_expression (exacerbation) of COPD in right pulmonary artery associated with pulmonary disease and thrombosis
15) Confidence 0.56 Published 2009 Journal Thromb J Section Body Doc Link PMC2699334 Disease Relevance 1.15 Pain Relevance 0
The PCT has been recognized as one of the best in the country at detecting COPD by the Eastern Region Public Health Observatory and has been placed in the top 10 for the detection of COPD against all other Primary Care Trusts in England [17].
Gene_expression (detecting) of COPD associated with pulmonary disease
16) Confidence 0.56 Published 2011 Journal Trials Section Body Doc Link PMC3024953 Disease Relevance 0.88 Pain Relevance 0
Previously, we have observed higher epithelial EGFR expression in ex-smokers with COPD compared to non-COPD, but not in current smokers, suggesting that current smoking may obscure differences in EGFR expression [13].
Gene_expression (expression) of COPD associated with pulmonary disease and nicotine addiction
17) Confidence 0.55 Published 2007 Journal Respir Res Section Body Doc Link PMC2214729 Disease Relevance 2.05 Pain Relevance 0.03
Reversal of epithelial remodelling may therefore contribute to reduced progression of COPD attributable to restored mucociliary clearance, resulting in reduced respiratory colonization [38] and exacerbations, and less small airways obstruction.
Gene_expression (progression) of COPD in respiratory associated with pulmonary disease
18) Confidence 0.55 Published 2007 Journal Respir Res Section Body Doc Link PMC2214729 Disease Relevance 1.63 Pain Relevance 0.11
This conclusion is supported by the results of a recent study that also failed to reveal differences in epithelial mucin expression in peripheral airways of COPD patients with or without chronic bronchitis [29].
Gene_expression (expression) of COPD associated with pulmonary disease and bronchitis
19) Confidence 0.55 Published 2007 Journal Respir Res Section Body Doc Link PMC2214729 Disease Relevance 1.57 Pain Relevance 0.03
Epithelial features in smokers versus ex-smokers with COPD
Gene_expression (smokers) of COPD associated with pulmonary disease and nicotine addiction
20) Confidence 0.55 Published 2007 Journal Respir Res Section Body Doc Link PMC2214729 Disease Relevance 1.56 Pain Relevance 0

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