INT147793

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Context Info
Confidence 0.64
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 70
Total Number 71
Disease Relevance 89.01
Pain Relevance 7.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lung 4
liver 2
plasma 1
Chest 1
epithelium 1
COPD (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1169 100.00 Very High Very High Very High
cytokine 168 100.00 Very High Very High Very High
fibrosis 108 100.00 Very High Very High Very High
rheumatoid arthritis 7 100.00 Very High Very High Very High
agonist 159 99.48 Very High Very High Very High
corticosteroid 235 99.42 Very High Very High Very High
cva 228 98.36 Very High Very High Very High
depression 59 98.00 Very High Very High Very High
Inflammatory response 110 96.96 Very High Very High Very High
Inflammatory mediators 126 95.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pulmonary Disease 4346 100.00 Very High Very High Very High
INFLAMMATION 1376 100.00 Very High Very High Very High
Disease 712 100.00 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 460 100.00 Very High Very High Very High
Asthma 213 100.00 Very High Very High Very High
Emphysema 177 100.00 Very High Very High Very High
Infection 101 100.00 Very High Very High Very High
Chronic Disease 80 100.00 Very High Very High Very High
Coronary Artery Disease 36 100.00 Very High Very High Very High
Diabetes Mellitus 33 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consequently, patients and their families frequently do not understand that severe COPD is often a progressive and terminal illness.
Localization (severe) of COPD associated with pulmonary disease
1) Confidence 0.64 Published 2008 Journal Eur. Respir. J. Section Abstract Doc Link 17989116 Disease Relevance 0.84 Pain Relevance 0.45
In the NICE,5 PLATINO,2 and BOLD (Burden of Lung Disease)1 studies, healthy people were surveyed for the prevalence of COPD.2,5,7 In primary care clinic settings, the participants suffered from some diseases, such as hypertension, diabetes mellitus, hyperlipemia, or liver disease.9 In our study, patients had some comorbidity (Tables 4 and 5), and in many cases, spirometry was performed before an operation.
Localization (prevalence) of COPD in liver associated with liver disease, pulmonary disease, diabetes mellitus, hypertension, hyperlipidemia and disease
2) Confidence 0.64 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2962301 Disease Relevance 1.42 Pain Relevance 0
This pilot service project provided several interventions: optimal medication, patient education, home care, and telephonic support, and is aimed at reducing hospitalization for COPD.
Localization (hospitalization) of COPD associated with pulmonary disease
3) Confidence 0.64 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2706601 Disease Relevance 1.35 Pain Relevance 0
Inhaled corticosteroids are such an option in acute exacerbation of COPD.
Localization (exacerbation) of COPD associated with corticosteroid and chronic obstructive pulmonary disease
4) Confidence 0.63 Published 2010 Journal Lung India : Official Organ of Indian Chest Society Section Body Doc Link PMC2988175 Disease Relevance 1.56 Pain Relevance 0.34
Sixty patients of acute exacerbation of COPD were randomly divided into three groups: nebulized budesonide, oral prednisolone and control group.
Localization (exacerbation) of COPD associated with chronic obstructive pulmonary disease
5) Confidence 0.63 Published 2010 Journal Lung India : Official Organ of Indian Chest Society Section Body Doc Link PMC2988175 Disease Relevance 0.38 Pain Relevance 0.13
In grouping together the trials in their analysis, Puhan et al have pooled together patients who are very heterogeneous with respect to their COPD disease and, therefore, could not discern a beneficial effect of antibiotics.
Localization (disease) of COPD associated with pulmonary disease and disease
6) Confidence 0.62 Published 2008 Journal BMC Med Section Body Doc Link PMC2569059 Disease Relevance 0.62 Pain Relevance 0
Huiart and colleagues, using a large administrative database from Saskatchewan, reported that COPD patients who used 50 to 200 ?
Localization (reported) of COPD associated with pulmonary disease
7) Confidence 0.60 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650603 Disease Relevance 1.13 Pain Relevance 0.21
Association analysis then identified TGFBR3 (betaglycan) as a potential susceptibility gene for COPD, which is supported by both murine and human microarray data.


Localization (supported) of COPD associated with pulmonary disease
8) Confidence 0.59 Published 2009 Journal Respir Res Section Body Doc Link PMC2678087 Disease Relevance 0.76 Pain Relevance 0.03
Patients were excluded if they had any recent respiratory tract infection, were hospitalised for a COPD exacerbation (6 weeks prior to Visit 1 or during the run-in period), had a history of asthma (indicated by, but not limited to, blood eosinophil count >400/mm3 or onset of respiratory symptoms prior to age 40 years) or any significant pulmonary disease or cardiovascular abnormality.
Localization (exacerbation) of COPD in respiratory associated with asthma, pulmonary disease, lower respiratory tract infection and cardiovascular abnormalities
9) Confidence 0.59 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2848004 Disease Relevance 0.84 Pain Relevance 0.08
However the burden of disease of COPD is proportionately even greater in the elderly.
Localization (disease) of COPD associated with pulmonary disease and disease
10) Confidence 0.57 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2692119 Disease Relevance 1.58 Pain Relevance 0
The earliest diagnosis date was recorded for nine HCUP categories: AMI, asthma, congestive heart failure, chronic obstructive pulmonary disease (COPD), diabetes, gastritis and duodenitis, hypertension, lupus or other connective tissue disease, and cerebrovascular disease.
Localization (disease) of COPD in connective tissue associated with heart rate under development, pulmonary disease, diabetes mellitus, duodenitis, disease, systemic lupus erythematosus, cerebrovascular disease, asthma, hypertension, gastritis and myocardial infarction
11) Confidence 0.57 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC3000429 Disease Relevance 2.18 Pain Relevance 0
This study showed that plasma C-reactive protein in combination with one major symptom is useful to confirm an exacerbation of COPD (Hurst et al 2006a).
Localization (exacerbation) of COPD in plasma associated with pulmonary disease
12) Confidence 0.54 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629961 Disease Relevance 1.24 Pain Relevance 0.39
8), status of COPD (unstable COPD = In- or outpatient medical care in the last eight weeks due to exacerbation of COPD versus stable COPD = no in- or outpatient medical care in the last eight weeks due to exacerbation of COPD) and the need for oxygen at rest (yes = long term home oxygen therapy or paO2 < 55 mmHg or no = paO2 ?
Localization (exacerbation) of COPD associated with pulmonary disease
13) Confidence 0.54 Published 2004 Journal BMC Pulm Med Section Body Doc Link PMC514611 Disease Relevance 1.41 Pain Relevance 0.08
8), status of COPD (unstable COPD = In- or outpatient medical care in the last eight weeks due to exacerbation of COPD versus stable COPD = no in- or outpatient medical care in the last eight weeks due to exacerbation of COPD) and the need for oxygen at rest (yes = long term home oxygen therapy or paO2 < 55 mmHg or no = paO2 ?
Localization (exacerbation) of COPD associated with pulmonary disease
14) Confidence 0.54 Published 2004 Journal BMC Pulm Med Section Body Doc Link PMC514611 Disease Relevance 1.40 Pain Relevance 0.08
8), status of COPD (unstable COPD = In- or outpatient medical care in the last eight weeks due to exacerbation of COPD versus stable COPD = no in- or outpatient medical care in the last eight weeks due to exacerbation of COPD) and the need for oxygen at rest (yes = long term home oxygen therapy or paO2 < 55 mmHg or no = paO2 ?
Localization (exacerbation) of COPD associated with pulmonary disease
15) Confidence 0.54 Published 2004 Journal BMC Pulm Med Section Body Doc Link PMC514611 Disease Relevance 1.50 Pain Relevance 0.08
The consequence in COPD is that the time needed for lung units to empty their volume and achieve their passive equilibrium point is significantly increased and many of them do not reach their relaxation volume before a new inspiration is initiated.
Localization (increased) of COPD in lung associated with chronic obstructive pulmonary disease
16) Confidence 0.54 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707802 Disease Relevance 0.17 Pain Relevance 0
Findings supportive of COPD on CXR include increased lung volumes and hyperinflation.
Localization (supportive) of COPD in lung associated with pulmonary disease
17) Confidence 0.53 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629964 Disease Relevance 2.66 Pain Relevance 0.42
2.1 How are the self-perceived symptoms of patients with severe to very severe COPD, CHF or CRF perceived by their closest relatives?
Localization (severe) of COPD associated with chronic renal failure, pulmonary disease and heart failure
18) Confidence 0.49 Published 2008 Journal BMC Palliat Care Section Body Doc Link PMC2391145 Disease Relevance 1.91 Pain Relevance 0
A recent study in 18 patients with COPD, CHF or CRF suggests that decreased independence and social isolation imposes a considerable burden of care on the family.[10] Additionally, Barnes and colleagues have shown that carers of CHF patients have other characteristics than carers of patients with cancer and need practical and emotional support.[27] At present, it remains unknown whether and to what extent self-perceived symptoms and care needs of patients with severe to very severe COPD, CHF or CRF may result in an extra caregiver burden for close relatives.
Localization (severe) of COPD associated with chronic renal failure, pulmonary disease, cancer and heart failure
19) Confidence 0.49 Published 2008 Journal BMC Palliat Care Section Body Doc Link PMC2391145 Disease Relevance 1.79 Pain Relevance 0
Management of these patients should prevent, relieve and/or soothe self-perceived symptoms and care needs to optimise daily functioning and stabilize disease-specific health status. [5-9] The management of patients with severe to very severe COPD, CHF or CRF should probably be a holistic type of care, equally concerned with physical, psychosocial and spiritual aspects of each patient.[10]
Localization (severe) of COPD associated with chronic renal failure, pulmonary disease, disease and heart failure
20) Confidence 0.49 Published 2008 Journal BMC Palliat Care Section Body Doc Link PMC2391145 Disease Relevance 2.11 Pain Relevance 0.06

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