INT147796

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.90
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ccndbp1) cell cycle (Ccndbp1) cytoplasm (Ccndbp1)
Anatomy Link Frequency
neuronal precursors 2
Ccndbp1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 1 97.84 Very High Very High Very High
Hippocampus 20 97.56 Very High Very High Very High
dexamethasone 1 96.32 Very High Very High Very High
vincristine 1 94.88 High High
agonist 1 75.00 Quite High
Pain 1 71.76 Quite High
Pyramidal cell 52 35.20 Quite Low
Inflammation 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 7 97.12 Very High Very High Very High
Reprotox - General 1 2 94.76 High High
Necrosis 32 92.64 High High
Sarcoma 98 92.00 High High
Cancer 140 90.60 High High
Stress 4 88.00 High High
Renal Disease 1 81.88 Quite High
Disease 106 81.12 Quite High
Multiple Myeloma 4 80.72 Quite High
Apoptosis 5 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The strong expression of cyclinD2, i.e. the only D-type cyclin expressed in dividing cells derived from neuronal precursors in adult hippocampus [35] prompted us to inject cyclinD2 deficient mice intracerebrally with AAV-Tau.P301L.
Gene_expression (expressed) of D-type cyclin in neuronal precursors associated with hippocampus
1) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748684 Disease Relevance 0.21 Pain Relevance 0.05
The strong expression of cyclinD2, i.e. the only D-type cyclin expressed in dividing cells derived from neuronal precursors in adult hippocampus [35] prompted us to inject cyclinD2 deficient mice intracerebrally with AAV-Tau.P301L.
Gene_expression (expression) of D-type cyclin in neuronal precursors associated with hippocampus
2) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748684 Disease Relevance 0.21 Pain Relevance 0.05
using preoperative radiotherapy together with the MAID regime

(MAID = mesna, adriamycin, ifosfamide, dacarbazine), DeLaney et al

Gene_expression (regime) of MAID
3) Confidence 0.03 Published 2006 Journal Sarcoma Section Body Doc Link PMC1510952 Disease Relevance 1.25 Pain Relevance 0
using preoperative radiotherapy together with the MAID regime

(MAID = mesna, adriamycin, ifosfamide, dacarbazine), DeLaney et al

Gene_expression (regime) of MAID
4) Confidence 0.03 Published 2006 Journal Sarcoma Section Body Doc Link PMC1510952 Disease Relevance 1.25 Pain Relevance 0
Chromosomes revealed a translocation of (11;14)(q13;q32), which is concordant with cyclinD1-protein overexpression by immunohistochemistry.
Gene_expression (overexpression) of cyclinD1-protein
5) Confidence 0.00 Published 2009 Journal Int. J. Hematol. Section Abstract Doc Link 19728026 Disease Relevance 0.64 Pain Relevance 0.17
Methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-diene-30-oate (beta-CDODA-Me) is a synthetic analog of the naturally occurring triterpenoid glycyrrhetinic acid, which contains a 2-cyano substituent in the A-ring. beta-CDODA-Me was a potent inhibitor of LNCaP prostate cancer cell growth (IC(50) approximately 1 muM) and activated peroxisome proliferator-activated receptor gamma (PPARgamma), whereas analogs without the cyano group were weakly cytotoxic and did not activate PPARgamma. beta-CDODA-Me induced p21 and p27, down-regulated cyclin D1 protein expression, and induced two other proapoptotic proteins, namely nonsteroidal anti-inflammatory drug-activated gene-1 and activating transcription factor-3.
Gene_expression (expression) of cyclin D1 protein associated with inflammation, cinod and reprotox - general 1
6) Confidence 0.00 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 17989348 Disease Relevance 0.34 Pain Relevance 0.14

General Comments

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