INT14780

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Context Info
Confidence 0.49
First Reported 1985
Last Reported 2003
Negated 3
Speculated 6
Reported most in Abstract
Documents 9
Total Number 15
Disease Relevance 4.33
Pain Relevance 10.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck)
Anatomy Link Frequency
neocortex 4
brain 4
body 4
hippocampus 4
spinal 2
Cck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 93 100.00 Very High Very High Very High
Somatostatin 32 100.00 Very High Very High Very High
Opioid 18 100.00 Very High Very High Very High
Morphine 8 100.00 Very High Very High Very High
MU agonist 3 100.00 Very High Very High Very High
Intracerebroventricular 2 100.00 Very High Very High Very High
Calcium channel 1 100.00 Very High Very High Very High
substance P 15 99.80 Very High Very High Very High
cerebral cortex 2 99.68 Very High Very High Very High
mu opioid receptor 1 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 7 99.56 Very High Very High Very High
Ganglion Cysts 4 98.04 Very High Very High Very High
Pressure And Volume Under Development 4 96.40 Very High Very High Very High
Epilepsy 6 92.12 High High
Body Weight 8 88.92 High High
Nociception 6 87.40 High High
Convulsion 15 84.68 Quite High
Pancreatitis 32 75.00 Quite High
Depression 1 75.00 Quite High
Pain 1 74.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, ablation of a similar amount of occipital neocortex did neither affect beta-endorphin actions nor the interactions of CCK-8.
Neg (neither) Regulation (affect) of CCK-8 Binding (interactions) of in neocortex
1) Confidence 0.49 Published 1985 Journal Peptides Section Abstract Doc Link 3162160 Disease Relevance 0 Pain Relevance 0.09
Extracellular recordings were made from supraoptic oxytocin (OT) neurones in rat brain slices to investigate the effect of reproductive state on their excitation by OT and cholecystokinin (CCK).
Spec (investigate) Regulation (effect) of CCK Binding (excitation) of in brain associated with cholecystokinin
2) Confidence 0.45 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14550902 Disease Relevance 0 Pain Relevance 0.34
In the present study, the whole-cell patch-clamp recording technique was employed to examine the effect of kappa-opioid agonist U50488H on voltage-gated calcium channels and the interaction between the CCK-8 and U50488H in acutely isolated rat dorsal root ganglion neurons.
Spec (examine) Regulation (effect) of CCK-8 Binding (interaction) of in dorsal root ganglion associated with ganglion cysts, mu agonist, calcium channel and root ganglion neuron
3) Confidence 0.45 Published 1996 Journal Brain Res. Section Abstract Doc Link 8883905 Disease Relevance 0.39 Pain Relevance 0.97
[Effect of amygdaloid kindling on thyrotropin-releasing hormone, somatostatin, cholecystokinin and substance P contents of the amygdala/piriform cortex and hippocampus of rats].
Regulation ([Effect) of cholecystokinin Binding (kindling) of in hippocampus associated with somatostatin, hippocampus, amygdala, cholecystokinin and substance p
4) Confidence 0.45 Published 1988 Journal No To Shinkei Section Title Doc Link 2465012 Disease Relevance 0.32 Pain Relevance 0.84
In contrast, the CCK-B receptor antagonist, L-365,260, did not affect contraction to CCK-8S (-log KB less than 7) but potently inhibited contraction to CCK-4 (-log KB = 9.24).
Neg (not) Regulation (affect) of CCK-8S Neg (not) Binding (contraction) of associated with antagonist and cholecystokinin
5) Confidence 0.44 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1704435 Disease Relevance 0 Pain Relevance 0.93
We examined the effects of intracerebroventricular (i.c.v.) injections of cholecystokinin-octapeptide (CCK-8) and somatostatin (SST) and the interactions of these neuropeptides with the selective opioid antagonists, CTAP (mu) and nor-BNI (kappa) and the mu-agonist, PL017, on body temperature (Tb) of the rat at normal ambient temperature (21 +/- 0.5 degrees C).
Spec (examined) Regulation (effects) of cholecystokinin Binding (interactions) of in body associated with antagonist, agonist, neuropeptide, somatostatin, opioid, cholecystokinin and intracerebroventricular
6) Confidence 0.42 Published 1997 Journal Brain Res. Section Abstract Doc Link 9037404 Disease Relevance 0.18 Pain Relevance 0.70
We examined the effects of intracerebroventricular (i.c.v.) injections of cholecystokinin-octapeptide (CCK-8) and somatostatin (SST) and the interactions of these neuropeptides with the selective opioid antagonists, CTAP (mu) and nor-BNI (kappa) and the mu-agonist, PL017, on body temperature (Tb) of the rat at normal ambient temperature (21 +/- 0.5 degrees C).
Spec (examined) Regulation (effects) of CCK-8 Binding (interactions) of in body associated with antagonist, agonist, neuropeptide, somatostatin, opioid, cholecystokinin and intracerebroventricular
7) Confidence 0.42 Published 1997 Journal Brain Res. Section Abstract Doc Link 9037404 Disease Relevance 0.18 Pain Relevance 0.70
Extracellular recordings were made from supraoptic oxytocin (OT) neurones in rat brain slices to investigate the effect of reproductive state on their excitation by OT and cholecystokinin (CCK).
Spec (investigate) Regulation (effect) of cholecystokinin Binding (excitation) of in brain associated with cholecystokinin
8) Confidence 0.39 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 14550902 Disease Relevance 0 Pain Relevance 0.34
Oestrogen modulates cholecystokinin: opioid interactions in the nervous system.
Regulation (modulates) of cholecystokinin Binding (interactions) of in nervous system associated with opioid and cholecystokinin
9) Confidence 0.39 Published 2002 Journal Pharmacol. Toxicol. Section Title Doc Link 12688384 Disease Relevance 0.15 Pain Relevance 0.63
The effect of morphine treatment on cholecystokinin (CCK) receptor binding in rat cerebral cortex was investigated.
Regulation (effect) of CCK Binding (binding) of in cerebral cortex associated with cerebral cortex, cholecystokinin and morphine
10) Confidence 0.26 Published 1994 Journal Neuropeptides Section Abstract Doc Link 7936125 Disease Relevance 0 Pain Relevance 1.18
Pancreatic function was decreased significantly with no alteration in CCK receptor binding.
Regulation (alteration) of CCK Binding (binding) of associated with cholecystokinin
11) Confidence 0.22 Published 2003 Journal Tob Induc Dis Section Abstract Doc Link PMC2669561 Disease Relevance 0.77 Pain Relevance 0.39
Pancreatic function was decreased significantly with no alteration in CCK receptor binding.
Neg (no) Regulation (alteration) of CCK Binding (binding) of associated with cholecystokinin
12) Confidence 0.22 Published 2003 Journal Tob Induc Dis Section Abstract Doc Link PMC2671550 Disease Relevance 0.77 Pain Relevance 0.39
[Effect of amygdaloid kindling on thyrotropin-releasing hormone, somatostatin, cholecystokinin and substance P contents of the amygdala/piriform cortex and hippocampus of rats].
Regulation ([Effect) of cholecystokinin in piriform cortex Binding (kindling) of in hippocampus associated with somatostatin, hippocampus, amygdala, cholecystokinin and substance p
13) Confidence 0.15 Published 1988 Journal No To Shinkei Section Title Doc Link 2465012 Disease Relevance 0.32 Pain Relevance 0.84
[Effect of amygdaloid kindling on thyrotropin-releasing hormone, somatostatin, cholecystokinin and substance P contents of the amygdala/piriform cortex and hippocampus of rats].
Regulation ([Effect) of cholecystokinin in amygdala Binding (kindling) of in hippocampus associated with somatostatin, hippocampus, amygdala, cholecystokinin and substance p
14) Confidence 0.15 Published 1988 Journal No To Shinkei Section Title Doc Link 2465012 Disease Relevance 0.32 Pain Relevance 0.84
With regard to exogenous opioids, the effectiveness of spinal morphine is rapidly enhanced after inflammation, likely to be due to changes in the interaction between the peptide cholecystokinin and the mu opioid receptor.
Regulation (changes) of cholecystokinin Spec (likely) Binding (interaction) of in spinal associated with inflammation, mu opioid receptor, cholecystokinin, opioid and morphine
15) Confidence 0.15 Published 1995 Journal Inflamm. Res. Section Abstract Doc Link 7583517 Disease Relevance 0.92 Pain Relevance 1.67

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