INT147808

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.03
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SLC6A4) endosome (SLC6A4) plasma membrane (SLC6A4)
Anatomy Link Frequency
villus 4
small intestine 2
SLC6A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 73 100.00 Very High Very High Very High
fluoxetine 13 92.84 High High
Calcium channel 8 48.56 Quite Low
potassium channel 16 44.16 Quite Low
imagery 8 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pigment Disorder 64 97.56 Very High Very High Very High
Enteropathy 3 88.72 High High
Cancer 64 5.00 Very Low Very Low Very Low
Skin Cancer 20 5.00 Very Low Very Low Very Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Metastasis 8 5.00 Very Low Very Low Very Low
Congenital Anomalies 6 5.00 Very Low Very Low Very Low
Neoplastic Processes 4 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Paralysis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Notably, SERT expression was localized predominantly to the apical and intracellular compartments and was distributed throughout the crypt-villus axis.
Positive_regulation (localized) of Gene_expression (expression) of SERT in villus
1) Confidence 0.50 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17991706 Disease Relevance 0.07 Pain Relevance 0.20
Real-time PCR studies showed relatively higher SERT mRNA expression in the human small intestine compared with colon (ileum >> duodenum >> jejunum).
Positive_regulation (higher) of Gene_expression (expression) of SERT mRNA in small intestine
2) Confidence 0.50 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17991706 Disease Relevance 0.09 Pain Relevance 0.12
Notably, SERT expression was localized predominantly to the apical and intracellular compartments and was distributed throughout the crypt-villus axis.
Positive_regulation (distributed) of Gene_expression (expression) of SERT in villus
3) Confidence 0.50 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17991706 Disease Relevance 0.07 Pain Relevance 0.21
Taken together, the data strongly suggest that function of the serotonin transporter SERT is required for the transduction of Vmem changes into cell behavior changes observed during hyperpigmentation.


Positive_regulation (required) of Gene_expression (function) of SERT associated with pigment disorder and serotonin
4) Confidence 0.09 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008964 Disease Relevance 0.40 Pain Relevance 0.52
Taken together, the data strongly suggest that function of the serotonin transporter SERT is required for the transduction of Vmem changes into cell behavior changes observed during hyperpigmentation.


Positive_regulation (required) of Gene_expression (function) of serotonin transporter associated with pigment disorder and serotonin
5) Confidence 0.08 Published 2011 Journal Disease Models & Mechanisms Section Body Doc Link PMC3008964 Disease Relevance 0.40 Pain Relevance 0.52

General Comments

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